A5018305956- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Appendicitis Diagnosis and Management
- Gastrointestinal Tumor Research and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Carbohydrate Chemistry and Synthesis
- Intraperitoneal and Appendiceal Malignancies
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Digestive system and related health
- Esophageal Cancer Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Pituitary Gland Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Trauma Management and Diagnosis
- Colorectal Cancer Surgical Treatments
- BRCA gene mutations in cancer
Centro Hospitalar de Trás os Montes e Alto Douro
2020-2024
University of Trás-os-Montes and Alto Douro
2023-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Association for the Development of Douro Viticulture
2023
Universidade do Porto
2009-2019
Centro Hospitalar do Tâmega e Sousa
2014-2019
Unidade Hospitalar de Bragança
2019
Glenfield Hospital
2019
University of Leicester
2019
Hospital de São João
2001-2015
Circulating O-glycoproteins shed from cancer cells represent important serum biomarkers for diagnostic and prognostic purposes. We have recently shown that selective detection of cancer-associated aberrant glycoforms circulating O-glycoprotein can increase specificity biomarker assays. However, the current knowledge secreted is limited. Here, we used COSMC KO "SimpleCell" (SC) strategy to characterize O-glycoproteome two gastric SimpleCell lines (AGS, MKN45) as well a cell line (KATO III)...
Breast cancer in young women is usually considered as breast occurring younger than 40 years and the most frequent cancer-related cause of death these patients. In past few years, there seems to be an increasing trend prevalence women, which, associated with poorer prognosis, more aggressive histologic features, recurrence rates, makes it a rising threat women. This study aimed evaluate biological behavior our institution.A retrospective, unicentric, cohort was conducted between 2012 2016....
Gastric cancer is preceded by a carcinogenesis pathway that includes gastritis caused Helicobacter pylori infection, chronic atrophic may progress to intestinal metaplasia (IM), dysplasia, and ultimately gastric carcinoma of the more common subtype. The identification glycosylation changes in circulating serum proteins patients with precursor lesions high interest represents source putative new biomarkers for early diagnosis intervention. This study applies glycoproteomic approach identify...
Malignant transformation of gastric cells is accompanied by the deregulated expression glycosyltransferases leading to biosynthesis tumor-associated glycans such as sialyl-Lewis X antigen (SLe x ).SLe presence on cell surface glycoconjugates increases invasive capacity cancer and associated with tumor metastasis.ST3Gal IV enzyme involved in synthesis SLe overexpressed carcinomas.Herein, we identified glycoproteins carrying overexpressing ST3Gal evaluated their biomarker potential for...
Appendix diverticulosis is a relatively rare pathological finding, more common in adult men over the age of 60 years. It generally an incidental finding on computed tomography (CT) and clinically asymptomatic. When symptomatic, it complicated by acute or chronic diverticulitis, with without appendicitis. may be associated appendix tumors, particularly mucinous ones. The article reports clinical case 68-year-old man referred to general surgery consultation due densification retrocecal fat...
Aberrant mucin O-glycosylation is often observed in cancer and characterized by the expression of immature simple mucin-type carbohydrate antigens. UDP- N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6) one enzymes responsible for initial step O-glycosylation. This study evaluated ppGalNAc-T6 human gastric mucosa, intestinal metaplasia, carcinomas. Our results showed that expressed normal mucosa metaplasia. A heterogeneous staining pattern this enzyme was...
<h3>Background and aims</h3> Intestinal metaplasia (IM) is a gastric preneoplastic lesion that appears following <i>Helicobacter pylori</i> infection confers an increased risk for development of cancer. It induced by expression the intestine-specific transcription factor CDX2. The regulatory mechanisms involved in triggering maintaining CDX2 have not been fully elucidated. Cdx2<sup>+/−</sup> mouse develops intestinal polyps with differentiation total loss Cdx2 absence structural second...
Gastric cancer remains a serious health concern worldwide. Patients would greatly benefit from the discovery of new biomarkers that predict outcome more accurately and allow better treatment follow-up decisions. Here, we used retrospective, observational study to assess expression prognostic value transcription factors SOX2 CDX2 in gastric cancer. SOX2, CDX2, MUC5AC MUC2 were assessed 201 tumors by immunohistochemistry. crossed with clinicopathological data determine their impact on tumor...
The HER-2/neu gene or c-erb B-2, localized on chromosome 17q, belongs to a family of tyrosine kinase receptors and shares extensive homology with the epidermal growth factor receptor. B-2 amplification protein overexpression have been reported in several human cancers. prognostic value this genetic alteration gastric carcinoma is far from being established. In present study, formalin-fixed, paraffin-embedded tissues 157 patients were evaluated for overexpression, by immunohistochemistry...
<i>Background/Aims: </i>The putative influence of tumor location on the biologic behavior gastric carcinomas remains controversial. The aim this study was to investigate if arising in three types mucosa (cardia, fundus/body and antrum) have different clinical pathologic profiles carry a prognosis. <i>Methods:</i> Three hundred two patients with cardia or carcinoma resected between 1984 1996 were retrospectively studied. Cases divided groups according location: (n =...
ABSTRACT Background: The Confusion Assessment Method (CAM) is the most widely used delirium screening instrument. aim of this study was to evaluate reliability and validity European Portuguese version CAM. Methods: sample included elderly patients (≥65 years), admitted for at least 48 h, into two intermediate care units (ICMU) Intensive Medicine Surgical Services in a university hospital. Exclusion criteria were: score ≤11 on Glasgow Coma Scale (GCS), blindness/deafness, inability...
Aims: Mutations in the gene coding for p53 protein are among most frequent genetic alterations observed human cancers. The relevance and biological significance of expression gastric carcinoma far from being fully established. aim our study was to evaluate influence detected by immunohistochemistry clinicopathological behaviour a series cases. Methods results: Samples 163 patients treated resection between 1988 1995 were used. Surgical specimens evaluated presence with monoclonal antibody....
Background . Considerable controversy persists about the biological behavior of gastric stump cancer (GSC). The aim this study is to clarify if just another proximal or it emerges as a distinctive clinicopathologic entity. Methods This review prospectively collected database identified 73 patients with GSC in single institution between January 1980 and June 2012 compared them 328 (PGC) 291 esophagogastric junction (EGJC). Results Patients were predominantly males. Eighty-three percent...
Intestinal malrotation (IM), a rare congenital anomaly disrupting typical embryonic rotation around the superior mesenteric artery, is exceptionally uncommon in adults, with its link to colon cancer being even rarer. This article presents case of colonic conjunction IM 63-year-old male. Image studies and intraoperative findings show signs IM. Open resection was performed due concerns about vascular anomalies abnormal lymphatic drainage. The underscores rarity malrotated gut, highlighting...
Background: The use of cervical drains to prevent hematoma or seroma after thyroidectomy remains a controversial issue. Objective: Identify clinical and surgical risk factors for evaluate the usefulness routine following thyroid surgery. Material methods: authors conducted retrospective multicentric study related consecutive patients submitted surgery in seven Portuguese hospitals between January 2018 December 2020 (n=945). data collected included parameters: age gender patients,...
<i>Background:</i> This study aimed to characterize the clinicopathological features and prognosis of early onset gastric carcinomas (EOGCs) in a sample young Portuguese adults. <i>Material Methods:</i> A subset 415 patients submitted resection was divided into 2 groups: – aged 45 years or less (n = 108), B older than 307). The groups were compared for several survival analyzed by uni- multivariate analysis. <i>Results:</i> surgical rate higher patients,...
Brunner's gland hyperplasia is a very rare lesion of the duodenum, which usually asymptomatic and diagnosed incidentally during upper gastrointestinal endoscopy. It can cause bleeding but hemorrhagic shock clinical presentation hyperplasia. The authors present case patient with due to hyperplasia, treated by urgent laparotomy polypectomy.
Jejunal gastrointestinal stromal tumors (GIST) are rare mesenchymal of the (GI) tract and a cause massive GI bleeding. Due to this rarity non-specific presentation, diagnosis treatment may be difficult often delayed. Urgent surgical intervention is crucial for controlling source bleeding total tumor excision. Herein, we present case 40-year-old male who presented emergency room (ER) with features upper He referred astheny black stools, was pale, sweaty, tachycardic despite normal blood...
Abdominal actinomycosis is a rare infection and the non-recognition of this particular microorganism may led to prolonged septic process recurrent disease.We hereby present case report 53 years-old woman with secondary peritonitis due our option perform long course penicillin derived antibiotics, after suture perforated gastric ulcer caused by foreign body.
Inflammatory pseudotumor (IP) is an uncommon benign neoplasm. It was first described in the lung but it has been recognized several somatic and visceral locations. Mesenteric presentation rare its clinical variable patients can be completely asymptomatic. Complete surgical resection only curable treatment. Rational follow-up protocols have not established yet. A 57 years-old man, with no relevant comorbidities asymptomatic, apart from a lump on right hypochondrium, submitted to of large...