A5029023037- Glycosylation and Glycoproteins Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Urinary Bladder and Prostate Research
- Peptidase Inhibition and Analysis
- Mindfulness and Compassion Interventions
- Diet and metabolism studies
- Nutrition, Health and Food Behavior
- Neuropeptides and Animal Physiology
- Carbohydrate Chemistry and Synthesis
- Lung Cancer Treatments and Mutations
- Galectins and Cancer Biology
- Perfectionism, Procrastination, Anxiety Studies
- Occupational Therapy Practice and Research
- Atrial Fibrillation Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Digestive system and related health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Helicobacter pylori-related gastroenterology studies
- HIV-related health complications and treatments
- Geriatric Care and Nursing Homes
Universidade do Porto
2012-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2019-2024
IPO Porto
2024
Hospitais da Universidade de Coimbra
2018
Malignant transformation of gastric cells is accompanied by the deregulated expression glycosyltransferases leading to biosynthesis tumor-associated glycans such as sialyl-Lewis X antigen (SLe x ).SLe presence on cell surface glycoconjugates increases invasive capacity cancer and associated with tumor metastasis.ST3Gal IV enzyme involved in synthesis SLe overexpressed carcinomas.Herein, we identified glycoproteins carrying overexpressing ST3Gal evaluated their biomarker potential for...
BACKGROUND AND AIMS: Aberrant cellular glycosylation remains a key event that accompanies and actively sustains gastric neoplastic transformation. Patient-derived organoids (PDOs) have recently emerged as promising ex vivo model to study human disorders. Since the PDOs landscape unknown, this aims evaluate potential avatars of in tissue profiles context. METHODS: Fresh mucosa samples derived from non-tumoral obese patients (n=11), adjacent tumor (n=29), cancer (GC) (n=30) were used establish...
The direct detrusor relaxant effect of β3-adrenoceptor agonists as a primary mechanism to improve overactive bladder symptoms has been questioned. Among other targets, activation β3-adrenoceptors downmodulate nerve-evoked acetylcholine (ACh) release, but there is insufficient evidence for the presence these receptors on cholinergic nerve terminals. Our hypothesis that adenosine formed from catabolism cyclic AMP in may act retrograde messenger via prejunctional A1 explain inhibition activity...
Abstract Expression of sialyl Lewis X (SLeX) is a well-documented event during malignant transformation cancer cells, and largely associates with their invasive metastatic properties. Glycoproteins glycolipids are the main carriers SLeX, whose biosynthesis known to be performed by different glycosyltransferases, namely family β-galactoside-α2,3-sialyltransferases (ST3Gals). In this study, we sought elucidate role ST3GalIV in SLeX properties gastrointestinal (GI) cells. By immunofluorescent...
ABSTRACT The objective of the article is to demonstrate how Palliative Care (PC) can be included in theory Model Human Occupation (MOHO). philosophy PC focuses on a client-centered approach like MOHO Occupational Therapy (OT). definition and role OT this camp are presented. A theoretical comparison was made perspective for Later Adulthood PC, focused dying persons. non-systematic review bibliography made. Therapist based evaluate help client maintain or re-gain his/her occupational identity,...
Background and Purpose The mechanism by which β 3 receptor agonists (e.g. mirabegron) control bladder overactivity may involve adenosine release from human rat detrusor smooth muscle. Retrograde activation of A 1 receptors reduces ACh cholinergic nerves. ‐Adrenoceptors usually couple to adenylyl cyclase. Here we investigated, the cAMP targets, protein kinase or exchange directly activated (EPAC) could be involved in this inhibition bladder. Experimental Approach [ H]ACh urothelium‐denuded...
Abstract Colorectal (CRC) and gastric (GC) cancers remain the top lethal targeted therapies in this setting are still very limited. Sialyl Lewis X (SLeX), a cancer-associated glycan highly expressed both CRC GC, plays crucial role cancer cell dissemination metastasis. Thus, presenting promising but underexplored therapeutic target. In work, we performed high-throughput screening (HTS) approach to identify potential inhibitors of SLeX expression on cells. Two libraries including total 7836...
Abstract Support better mental health is a long-term investment. Stressful life events and chronic adversity have substantial impact on brain functions may result in problems. Stress during academic was already established as problem, university students high-stress rate. Create improve strategies to lower those levels can increase student wellbeing. Smartphones connect individuals across the world, its software applications ability facilitate behavior change. Mindfulness-based interventions...
<b>Introduction:</b> Alpha1-Antitrypsin Deficiency (AATD) is a largely underdiagnosed hereditary disease associated with the development of emphysema at young age. Strategies to improve detection include screening target groups like COPD patients. Current guidelines do not recommend for AATD in patients pneumothorax, although this matter controversy. Few studies have addressed issue; some support measurement AAT serum levels spontaneous pneumothorax while others show no benefit. <b>Aim:</b>...
Abstract Expression of sialyl Lewis X (SLeX) is a well-documented event during malignant transformation cancer cells, and largely associates with their invasive metastatic properties. Glycoproteins glycolipids are the main carriers SLeX, whose biosynthesis known to be performed by different glycosyltransferases, namely family β-galactoside-α2,3-sialyltransferases (ST3Gals). In this study, we sought elucidate role ST3GalIV in SLeX properties gastrointestinal (GI) cells. By immunofluorescent...