A5013479692- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Proteoglycans and glycosaminoglycans research
- Plant Pathogens and Fungal Diseases
- Synthesis of Organic Compounds
- Metastasis and carcinoma case studies
- Synthesis and Biological Evaluation
- Obesity, Physical Activity, Diet
- Nail Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Antibiotic Resistance in Bacteria
- Carbohydrate Chemistry and Synthesis
- Esophageal Cancer Research and Treatment
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Helicobacter pylori-related gastroenterology studies
- Microbial Community Ecology and Physiology
- Vibrio bacteria research studies
- Phytochemical Studies and Bioactivities
- Liver Disease Diagnosis and Treatment
- Legionella and Acanthamoeba research
- Child Nutrition and Feeding Issues
- Cardiac Valve Diseases and Treatments
Hospital de São João
2024-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Universidade do Porto
2014-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2021-2024
IPO Porto
2021-2024
Instituto do Câncer do Estado de São Paulo
2023
Universidade de São Paulo
2023
Centre for Health Technology and Services Research
2016
Rutgers, The State University of New Jersey
2011-2012
University of Aveiro
2012
Objective To evaluate the risk factors for lymph node metastasis (LNM) after a non-curative (NC) gastric endoscopic submucosal dissection (ESD) and to validate eventually refine eCura scoring system in Western setting. Also, assess rate parietal residual disease. Design Retrospective multicentre multinational study of prospectively collected registries from 19 centres. Patients who had been submitted surgery or at least one follow-up endoscopy were included. The was applied its accuracy...
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), transmembrane proteoglycan, highly expressed in intestinal subtype gastric tumors and this signature associates patient poor survival. Further, mechanistically demonstrate SDC4 master regulator cell motility invasion. We also find decorated heparan sulfate efficiently sorted extracellular vesicles (EVs). Interestingly, EVs regulates cell-derived EV organ...
The purpose of this study was to unveil whether azole antifungals used in agriculture, similar the clinical azoles humans, can evoke resistance among relevant human pathogens like Aspergillus fumigatus, an ubiquitous agent nature. Additionally, cross-resistance with investigated. Antifungal susceptibility testing environmental and isolates A. fumigatus performed according CLSI M38-A2 protocol. In vitro induction assays were conducted involving daily incubation susceptible isolates, at 35°C...
BACKGROUND AND AIMS: Aberrant cellular glycosylation remains a key event that accompanies and actively sustains gastric neoplastic transformation. Patient-derived organoids (PDOs) have recently emerged as promising ex vivo model to study human disorders. Since the PDOs landscape unknown, this aims evaluate potential avatars of in tissue profiles context. METHODS: Fresh mucosa samples derived from non-tumoral obese patients (n=11), adjacent tumor (n=29), cancer (GC) (n=30) were used establish...
Background: While immigrant children often exhibit better breastfeeding practices, they may face challenges in maintaining a healthy diet and engaging organized sports. Despite the growing child population Portugal, evidence on these behaviours, particularly among preschool aged children, remains limited. In this context, study examines associations between migrant status patterns, fruit vegetable consumption participation sports living Lisbon Metropolitan Area. Methods: Cross-sectional...
Background: Being breastfed, following a healthy diet and staying active during childhood shape health trajectories across the life course, promoting long-term well-being. Despite growing immigrant child population in Portugal, evidence on these behaviours, particularly among preschool-aged children, remains limited. In this context, study examines associations between migrant status breastfeeding patterns, fruit vegetable consumption, participation sports children living Lisbon Metropolitan...
Candida krusei is an important agent of opportunistic infections that often displays resistance to several antifungals. We describe here the in vivo acquisition voriconazole (VRC) by C. isolates recovered from a leukemia patient during long period VRC therapy. In order mimic development resistance, susceptible isolate was exposed daily 1 μg/ml vitro. Interestingly, after 5 days exposure VRC, MIC 4 achieved; this value remained constant 25 additional treatment with and also 30 consecutive...
BACKGROUND : Endoscopic submucosal dissection (ESD) in colorectal lesions is technically demanding and a significant rate of noncurative procedures expected. We aimed to assess the residual after ESD for cancer (CRC) establish predictive scores be applied clinical setting. METHODS Retrospective multicenter analysis consecutive ESDs. Patients with ESDs performed treatment CRC submitted complementary surgery or at least one follow-up endoscopy were included. RESULTS From 2255 ESDs, 381 (17 %)...
Acquisition of azole resistance by clinically relevant yeasts in nature may result a significant, yet undetermined, impact human health. The main goal this study was to assess the development cross-resistance between agricultural and clinical azoles Candida spp. An vitro induction assay performed, for period 90 days, with prochloraz (PCZ) – an antifungal. Afterward, induced molecular mechanisms were unveiled. MIC value PCZ increased significantly all isolates. However, only C. glabrata...
Heparan sulfate (HS) proteoglycans (HSPGs) are abundant glycoconjugates in cells’ glycocalyx and extracellular matrix. By acting as scaffolds for protein–protein interactions, HSPGs modulate ligand gradients, cell signaling networks, cell–extracellular matrix crosstalk. Aberrant expression of enzymes involved HSPG biosynthesis processing has been reported tumors, with impact cancer behavior tumor microenvironment properties. However, the roles specific glycosyltransferases deregulated not...
Abstract Expression of sialyl Lewis X (SLeX) is a well-documented event during malignant transformation cancer cells, and largely associates with their invasive metastatic properties. Glycoproteins glycolipids are the main carriers SLeX, whose biosynthesis known to be performed by different glycosyltransferases, namely family β-galactoside-α2,3-sialyltransferases (ST3Gals). In this study, we sought elucidate role ST3GalIV in SLeX properties gastrointestinal (GI) cells. By immunofluorescent...
To compare the clinical efficacy of capsule-rupturing versus capsule-preserving ultrasound-guided hydrodilatation in patients with shoulder adhesive capsulitis (AC). determine potential factors affecting outcome over a 6-month follow-up.Within 2-year period, 149 consecutive AC were prospectively enrolled and allocated into (i) group-CR, including 39 receiving glenohumeral joint (GHJ) capsular rupture (ii) group-CP, 110 treated GHJ preservation. Demographics, affected shoulder, grade...
A flow cytometry test was developed to identify carbapenemase production by Enterobacteriaceae and discriminate between the different types of carbapenemases (classes A, B, D). It is based on detection meropenem activity against bacteria, coupled with inhibitors, which assessed cytometry. represents a convenient, fast, reliable approach (100% sensitivity 100% specificity) for characterization carbapenemases.
Abstract Invasive aspergillosis (IA) is a potentially lethal infection that affects mostly immunocompromised patients caused by Aspergillus fumigatus . Echinocandins are second-line therapy against IA, used as salvage well for empirical or prophylactic therapy. Although they cause lysis of growing hyphal tips, considered fungistatic molds. In vivo echinocandins resistance uncommon; however, its wide clinical use could shortly lead to the emergence A. resistance. The aims present work was...
Abstract Authors have recently suggested that difficult temperament in infancy may be associated with rapid weight gain, but no previous studies actually report associations between and feeding as a response to infant distress. The purpose of the present study was examine whether greater difficulty elicits more feeding, which turn leads gain early infancy. One hundred fifty‐four mother–infant pairs were visited at 3 6 months their homes. Besides anthropometric measures, mothers kept 24‐h...
Abstract Colorectal (CRC) and gastric (GC) cancers remain the top lethal targeted therapies in this setting are still very limited. Sialyl Lewis X (SLeX), a cancer-associated glycan highly expressed both CRC GC, plays crucial role cancer cell dissemination metastasis. Thus, presenting promising but underexplored therapeutic target. In work, we performed high-throughput screening (HTS) approach to identify potential inhibitors of SLeX expression on cells. Two libraries including total 7836...
Clinical epidemiological data about the distinct Malassezia species remain scarce. The recurrence of Malassezia-related skin diseases, despite long-term use antifungals, raises concern hypothetical emergence antifungal resistance. We aimed to assess distribution among patients from a University Hospital with pityriasis versicolor, seborrheic dermatitis and healthy volunteers, evaluate susceptibility profile classic antifungals over-the-counter compounds, searching for clinical...