A5076942460- Synthesis of Tetrazole Derivatives
- Synthesis and Characterization of Heterocyclic Compounds
- RNA Interference and Gene Delivery
- Photoreceptor and optogenetics research
- interferon and immune responses
- Photochromic and Fluorescence Chemistry
- Anodic Oxide Films and Nanostructures
- Problem and Project Based Learning
- Various Chemistry Research Topics
- Retinal Development and Disorders
- Synthesis of heterocyclic compounds
- RNA modifications and cancer
- Innovative Teaching Methods
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Antimicrobial Peptides and Activities
- Click Chemistry and Applications
- Cancer-related molecular mechanisms research
- Nanofabrication and Lithography Techniques
- Advanced biosensing and bioanalysis techniques
- Protein purification and stability
- Silk-based biomaterials and applications
- biodegradable polymer synthesis and properties
- Monoclonal and Polyclonal Antibodies Research
- Microwave-Assisted Synthesis and Applications
Korea Advanced Institute of Science and Technology
2018-2023
St. Petersburg State Technological Institute
2000-2003
Protein kinase R (PKR) is an immune response protein that becomes activated by double-stranded RNAs (dsRNAs). PKR overactivation associated with degenerative diseases inflammation, including osteoarthritis (OA), but the dsRNA activator remains largely unknown. Here, we find mitochondrial (mt-dsRNA) expression and its cytosolic efflux are facilitated in chondrocytes under OA-eliciting conditions, leading to innate activation. Moreover, mt-dsRNAs released extracellular space activate Toll-like...
Reactive poly(pentafluorophenyl acrylate) (PPFPA)-grafted surfaces offer a versatile platform to immobilize biomolecules. Here, we utilize PPFPA-grafted surface and double-stranded RNA (dsRNA) recognizing J2 antibody construct universal virus detection with enhanced sensitivity. PPFPA on silicon substrates is prepared, hydrophilicity modulated by partial substitution of the pentafluorophenyl units poly(ethylene glycol). Following dsRNA immobilization, prepared can distinguish long dsRNAs...
Long double-stranded RNAs (dsRNAs) are duplex that can induce immune response when present in mammalian cells. These historically associated with viral replication, but recent evidence suggests human cells naturally encode endogenous dsRNAs regulate antiviral machineries cellular contexts beyond response. In this study, we use photochromic organic compound spiropyran to profile and quantitate dsRNA expression. We show the open form of spiropyran, merocyanine, intercalate between RNA base...
The paper describes guidelines for the planning, organization, and implementation of virtual activities within a metaverse environment, aiming to familiarize students with key concepts related hard soft acids bases (HSAB) theory. are based on experience gained during an online lesson given in January 2022 188 incoming freshmen at large Korean university week-long science program. proposed involves three parts: 1) lecture describing HSAB theory, which was conducted Zoom; 2) group work...
Hypomethylating agents (HMAs), such as azacitidine and decitabine, induce cancer cell death by demethylating DNAs to promote the expression of tumor-suppressor genes. HMAs also reactivate transcription endogenous double-stranded RNAs (dsRNAs) that trigger innate immune response subsequent apoptosis via viral mimicry. However, patterns dsRNAs their relevance in efficacy remain largely uninvestigated. Here, we employ amidine-conjugated spiropyran (Am-SP) examine dynamic pattern total regulated...
We demonstrate a simple method to prepare poly(pentafluorophenyl acrylate) (poly(PFPA)) grafted silica beads for antibody immobilization and subsequent immunoprecipitation (IP) application. The poly(PFPA) surface is prepared via two-step process. In the first step, 3-aminopropyltrimethoxysilane (APTMS) deposited as linker molecule onto surface. second homopolymer, synthesized reversible addition fragmentation chain transfer (RAFT) polymerization, through exchange reaction between...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract For see ChemInform in Full Text.
Abstract For see ChemInform in Full Text.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”