A5013003607- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Diabetes Treatment and Management
- Orthopedic Infections and Treatments
- Neuropeptides and Animal Physiology
- Hip and Femur Fractures
- Trauma and Emergency Care Studies
- Knee injuries and reconstruction techniques
- Heart Failure Treatment and Management
- Pelvic and Acetabular Injuries
- Hip disorders and treatments
- Bone fractures and treatments
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Bone and Joint Diseases
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Lower Extremity Biomechanics and Pathologies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Musculoskeletal Disorders and Rehabilitation
- Traumatic Ocular and Foreign Body Injuries
- Anesthesia and Pain Management
Musgrave Park Hospital
2018-2024
Belfast Health and Social Care Trust
2019-2024
Orthopaedic Trauma Association
2021
Queen's University Belfast
2008-2015
Great Ormond Street Hospital
2014
University College London
2014
University of Ulster
2005-2007
University of Liverpool
2007
The gut hormone gastric inhibitory polypeptide (GIP) plays a key role in glucose homeostasis and lipid metabolism. This study investigated the effects of administration stable specific GIP receptor antagonist, (Pro 3 )GIP, mice previously fed high-fat diet for 160 days to induce obesity related diabetes. Daily intraperitoneal injection )GIP over 50 significantly decreased body weight compared with saline-treated controls, modest increase locomotor activity but no change intake. Plasma...
Aims The aim of this study was to determine both the incidence of, and reoperation rate for, postoperative periprosthetic femoral fracture (POPFF) after total hip arthroplasty (THA) with either a collared cementless (CC) component or cemented polished taper-slip (PTS) component. Methods We performed retrospective review consecutive series 11,018 THAs over ten-year period. All POPFFs were identified using regional radiograph archiving electronic care systems. Results A implanted: 4,952 CC...
Glucagon-like peptide-1 (GLP-1) is an insulin-releasing hormone clinically exploited for glycaemic control in diabetes, which also confers acute cardioprotection and benefits experimental/clinical heart failure. We specifically investigated the role of GLP-1 mimetic, exendin-4, post-myocardial infarction (MI) remodelling, a key contributor to Adult female normoglycaemic mice underwent coronary artery ligation/sham surgery prior infusion with exendin-4/vehicle 4 weeks. Metabolic parameters...
Aims Now that we are in the deceleration phase of COVID-19 pandemic, focus has shifted to how safely reinstate elective operating. Regional and speciality specific data is important guide this decision-making process. This study aimed review 30-day mortality for all patients undergoing orthopaedic surgery during peak pandemic within our region. Methods multicentre reviewed on trauma a region from 18 March 2020 27 April 2020. Information was collated regional databases. Patients were...
The aim of this study was to report health-related quality life (HRQoL) and joint-specific function in patients waiting for total hip or knee arthroplasty surgery (THA TKA) Northern Ireland, compared published literature a matched normal population. Secondary aims were emergency department (ED) out-of-hours general practitioner (OOH GP) visits, new prescriptions strong opioids, antidepressants while waiting.This cohort 991 on the list single Ireland NHS trust: 497 ≤ three months; 494 ≥...
Abstract Background The two major incretin hormones, glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are being actively explored as anti‐diabetic agents because they lower blood glucose through multiple mechanisms. rapid inactivation of GIP GLP‐1 by the ubiquitous enzyme, dipeptidyl peptidase IV (DPP IV) makes their biological actions short‐lived, but stable agonists such N ‐acetylated ( ‐AcGIP) exendin(1‐39)amide have been advocated specific analogues....
The aim of this retrospective audit was to determine the route referral or presentation patients requiring revision following primary total hip arthroplasty (THA).A 4802 were implanted with an Orthopaedic Data Evaluation Panel (ODEP) 10A* cementless implant (Corail/Pinnacle) between 2005 and 2015; 80 a mean age 67.8 years (sd 10.8) underwent subsequent revision. outcome measure for revision.Of revisions, 31 (38.8%) took place within first year 69 (86.3%) six years. Only two picked up at...
Abstract Background Whether increased BMI is associated with an risk of venous thromboembolism (VTE) controversial. Despite this, > 40 kg/m 2 remains a common cutoff for lower limb arthroplasty eligibility. Current United Kingdom national guidelines list obesity as factor VTE, but these are based on evidence that has largely failed to differentiate between potentially minor (distal deep vein thrombosis [DVT]), and more harmful (pulmonary embolism [PE] proximal DVT) diagnoses. Determining...
Vascular dysfunction can develop from consumption of an energy-rich diet, even prior to the onset obesity. However, roles played by different dietary components remain uncertain. While attempting models obesity in a separate study, we observed that two high-energy diets differing macronutrient compositions affected vascular function differently overweight rats.Male Wistar rats (n = 6/group) were fed providing varying percentages energy fat and carbohydrate (CHO). For 10 weeks, they either...
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine K-cells in response to nutrient absorption. This study has utilised numerous well-characterised dipeptidyl peptidase IV-resistant GIP analogues evaluate the glucagonotropic actions of Wistar rats and isolated rat islets. Intraperitoneal administration (25 nmol/kg body weight) combination with glucose had no effect on circulating glucagon concentrations compared controls rats. However, plasma were...
Rapidly progressive osteoarthritis (RPO) is a rare condition which poorly understood. Limited published literature available. Reported here cohort of patients with RPO and acetabular bone loss who underwent primary THA. Risk factors, degree outcomes are presented. A typical case described investigations discussed. retrospective audit was undertaken. 49 over an 18-year period were included. significantly older (P < 0.01) had lower BMI = 0.03). The mean in this 10.0 mm. Pathogenesis risk...
Aims Previous research has demonstrated increased early complication rates following total hip arthroplasty (THA) in obese patients, as defined by body mass index (BMI). Subcutaneous fat depth (FD) been shown to be an independent risk factor for wound infection cervical and lumbar spine surgery, well after abdominal laparotomy. The aim of this study was investigate whether peritrochanteric FD associated with complications the first year THA. Methods We analyzed prospectively collected data...
Aims Up to one in five patients undergoing primary total hip (THA) and knee arthroplasty (TKA) require contralateral surgery. This is frequently performed as a staged procedure. study aimed determine if outcomes, determined by the Oxford Hip Score (OHS) Knee (OKS) differed following second-side Methods Over five-year period all who underwent bilateral THA or TKA utilizing same type of implants were studied. Eligible had both preoperative year scores their second procedure completed within...