A5056005409- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- Child Nutrition and Water Access
- Research on Leishmaniasis Studies
- Amoebic Infections and Treatments
- Trypanosoma species research and implications
- Trace Elements in Health
- Vitamin K Research Studies
- Parasitic Infections and Diagnostics
- Vitamin D Research Studies
- Natural Compound Pharmacology Studies
- Dermatological diseases and infestations
- Gut microbiota and health
- Parasitic infections in humans and animals
- Allelopathy and phytotoxic interactions
- Dietary Effects on Health
- Parasitic Diseases Research and Treatment
- Synthesis and Biological Evaluation
- Drug-Induced Hepatotoxicity and Protection
Universidade Federal de Alfenas
2016-2025
Although curcumin can increase the effectiveness of drugs against malaria, combination therapies using molecule have never been investigated in Chagas disease (ChD). Therefore, we evaluated efficacy as a complementary strategy to benznidazole (Bz)-based chemotherapy mice acutely infected with Trypanosoma cruzi Eighty-four 12-week-old Swiss were equally randomized into seven groups: uninfected (NI), T. and untreated (INF), treated 100 mg/kg body weight Bz (B100), 50 (B50), (C100), plus (B100...
We investigated the effect in vitro and vivo of doxycycline hyclate (Dx), a broad-spectrum antibiotic inhibitor matrix metaloproteinases (MMPs), on adult Schistosoma mansoni worms granulomatous liver inflammation infected mice. Adult S. culture treated with different concentrations Dx (50–180 μg/mL) were studied for eight days to assess its morphology, eggs production, mortality. Uninfected mice those mansoni, untreated praziquantel (Pz; 200 mg/kg) or (50 mg/kg), evaluated 60 days. Our...
Hosts and their microbiota parasites have co-evolved in an adaptative relationship since ancient times. The interaction between intestinal bacteria terms of the hosts’ health is currently a subject great research interest. Therapeutic interventions can include manipulations structure microbiota, which immunological interactions important for modulating host’s immune system reducing inflammation. Most helminths are parasites; environment provides complex with other microorganisms internal...
Eugenol shows both antibacterial and antiparasitic activities, suggesting that it might be evaluated as an option for the treatment of praziquantel-resistant schistosome.The in vitro activities three eugenol derivatives (FB1, FB4 FB9) on adult worms from Schistosoma mansoni were examined by fluorescence scanning electron microscopy to analyze effects excretory system integument damage, respectively. Biochemical tests with verapamil (a calcium channel antagonist) ouabain Na+/K+-ATPase pump...
The pathogens Schistosoma mansoni and Paracoccidioides brasiliensis share common geographic areas, determining infectious diseases with high mortality rates worldwide . Histopathological immunological changes induced by each pathogen are well understood; however, the host responses to S. P. coinfection still unknown. Thus, we investigated liver damage cytokines production in a murine model acutely chronically coinfected these pathogens. Fourty male Swiss mice were infected alone or...
Este estudo foi desenvolvido com o objetivo de contribuir a vigilância da esquistossomose, no âmbito Superintendência Regional Saúde Alfenas, MG, na mesorregião Sul/Sudoeste do estado, considerada não endêmica para ao contrário outras áreas norte e nordeste estado. Durante ano 2015, os escolares migrantes dois municípios dessa região, Arceburgo Guaranésia, foram submetidos aos inquéritos parasitológico sorológico. No inquérito parasitológico, nenhum caso esquistossomose detectado em...
INTRODUCTION: In most Strongyloides stercoralis infected individuals, nematoidosis occurs asymptomatically, but in immunocompromised patients, it can cause hyperinfection. Serological techniques seem to be a good alternative for detecting this parasite. METHODS The frequency of seropositivity strongyloidiasis Alfenas, MG, was estimated using the enzyme linked immunosorbent assay on blood samples, between May and August 2015. RESULTS: Out 258 samples tested, 53.9% were positive, seropositive...
We investigated the relationship between inducible nitric oxide synthase (iNOS) and arginase pathways, cytokines, macrophages, oxidative damage lung granulomatous inflammation in S. mansoni-infected doxycycline-treated mice. Swiss mice were randomized four groups: (i) uninfected, (ii) infected with mansoni, (iii) + 200 mg/kg praziquantel (Pzt), (iv) (v) 5 50 doxycycline. Pzt (reference drug) was administered a single dose doxycycline for 60 days. mansoni-infection determined extensive...
Intestinal parasitic infections are common among pre-school children in developing countries and they often associated with gastrointestinal morbidity such as chronic diarrhea malnutrition. Their circulation is mainly lack of personal hygiene environmental sanitation, well limited housing food conditions. As the diagnosis intestinal parasites not a simple procedure, especially population studies, due to difficultiesencountered strategies obtain fecal samples, reliable prevalence data scarce....
Este trabalho constitui parte de um projeto intitulado “Esquistossomose e enteroparasitoses: vigilância epidemiologica associada a educacao ambiental em saude”, que vem sendo desenvolvido com o objetivo dimensionar problema da esquistossomose das enteroparasitoses, para planejamento implantacao programa controle mesmas, municipios localizados na area abrangencia Superintendencia Regional Saude Alfenas-MG (SRS-Alfenas), regiao sul/sudoeste do estado. A pesquisa enteroparasitoses uma populacao...
Abstract 7-epiclusianone (7-epi), a benzophenone isolated from fruits of Garcinia brasiliensis , presents remarkable biological activities as the schistosomicidal. However, there is need to evaluate toxic effects 7-epi by analyzing liver function markers (aspartate-aminotransferase, alanine-aminotransferase, albumin, total proteins, and glucose) renal marker (creatinine), beside that also comet (COM), micronucleus (MN), apoptosis (APOP), histopathological in vivo analyzes. Although at doses...