A5087564252- Induction Heating and Inverter Technology
- Renal Diseases and Glomerulopathies
- Smoking Behavior and Cessation
- Silicon Carbide Semiconductor Technologies
- Advanced DC-DC Converters
- Electromagnetic Compatibility and Noise Suppression
- Multilevel Inverters and Converters
- Chronic Lymphocytic Leukemia Research
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Noise Effects and Management
- Behavioral Health and Interventions
- Clinical practice guidelines implementation
- COVID-19 and Mental Health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Eosinophilic Esophagitis
- Blood disorders and treatments
- Insects and Parasite Interactions
- Dermatological diseases and infestations
- Urinary Bladder and Prostate Research
- Reproductive Health and Technologies
- Health Systems, Economic Evaluations, Quality of Life
- Fungal Infections and Studies
Universidade Estadual de Campinas (UNICAMP)
2024
San Diego State University
2021-2024
Harvard University
2019-2022
Beth Israel Deaconess Medical Center
2019-2022
CHRISTUS Transplant Institute
2015
Hospital Clínico Universitario de Valencia
1994-2011
ONA Electroerosion (Spain)
2007
Significance Specific APOL1 variants are a strong risk factor for human kidney disease. Previous reports examining the intracellular localization of protein in and glomerular podocytes have yielded inconsistent results. Here we demonstrate differential wild-type variant polypeptides, with wild type localizing predominantly to lipid droplets forms endoplasmic reticulum. We further that modulates cytotoxic effects, perturbations increasing droplet polypeptides decrease this cytotoxicity. These...
ABSTRACT People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting copies these risk variants, known as G1 and G2, causes high rates focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy hypertension-associated end-stage disease. Disease follows a recessive mode inheritance, which puzzling given considerable data that G2 are...
Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly associated with African ancestry major contributors to large racial disparity rates of human kidney disease. We previously demonstrated recruitment APOL1 risk G1 and G2 from endoplasmic reticulum lipid droplets leads reduced APOL1-mediated cytotoxicity podocytes.We used CRISPR-Cas9 editing induced pluripotent stem cells develop human-derived APOL1G0/G0 APOL1G2/G2 organoids on an isogenic background, performed bulk...
There are limited data available supporting the use of recombinant granulocyte colony–stimulating factor (G-CSF), tbo-filgrastim, rather than traditionally used filgrastim to mobilize peripheral blood stem cells (PBSC) or accelerate engraftment after autologous cell transplantation (ASCT). We sought compare efficacy and cost tbo-filgrastim in these settings. Patients diagnosed with lymphoma plasma disorders undergoing G-CSF mobilization, without plerixafor, were included this retrospective...
This paper analyses a high power (50 kW), frequency (150 kHz) voltage fed inverter with series resonant load circuit for industrial induction heating applications which is characterized by full bridge made IGBT and the control based on pulse density modulation (PDM). strategy allows that works close to resonance all output levels. In this situation zero-voltage switching (ZVS) zero-current (ZCS) conditions are performed losses minimized. The results verified experimentally using prototype...
This study was designed to examine how the COVID-19 pandemic changed e-cigarette user habits and risk perceptions. A nationally distributed 52-item questionnaire assessed nicotine use, perceptions, diagnosis, demographic data, vaping among respondents aged 16-96 years (n = 565). Questions were developed in-house assess of users perceptions containing non-users both before during pandemic. Seventy-six percent believed that use would lead worse symptoms, compared 40% (P < 0.001). Twenty-eight...
Background Behavioural research is needed to inform a ban on sales of filtered cigarettes that could reduce plastic waste due discarded filters. This study reports differences in perceptions, nicotine dependence and behaviour among participants cross-over randomised trial compared with unfiltered cigarettes. Method proof-of-concept involved 43 people who smoke (41.9% women, mean age 36.7 years). Participants were provided 2 weeks’ supply cigarettes, weeks the same brand randomly assigned...
The main reason for conducting a clinical trial (CT) is to test the effect of drug or medical procedure improve treatment disease. CTs contribute most when they are rigorously conducted and results published adequately. aim this study assess, using CONSORT statement guidelines, quality reporting completed at tertiary hospital determine which sections articles should be improved. between 2002 2008 were identified by searching MEDLINE Cochrane Library. Forty 127 published. There was marked...
Smoking topography (ST) describes smoking behavior and patterns. Removal of the cigarette filter subsequent impact on ST has not been investigated. This is first clinical trial comparing for filtered unfiltered cigarettes in a naturalistic experiment. We conducted crossover following established people who smoke (n = 32) two weeks under experimental conditions. Participants (50 % female, mean age 38.3 yr.) smoked each condition followed by 3-week post-washout period. (puff count, volume,...
As Forças Armadas militam constantemente para manter suas tropas em condições de agir quando demandado, o que pode ser expresso pelo conceito prontidão combate. Neste sentido, torna-se essencial estruturar programas treinamento físico apropriados e avaliações confiáveis, juntos podem contribuir preparo adequado dos militares no desempenho tarefas específicas. A literatura apresenta informações dispersas a respeito do desenvolvimento validação testes físicos atletas táticos, tendo vista se...
The fact that some inverter topologies used in induction heating applications allow the soft switching working operation lets progressive replacement of MOSFET with IGBT high power inverters. This is due to two main reasons, former reliability and latter ratio defined as price component per output power. In this article an automated method determine based on frequency build different described. To carry out necessary define cycle develop calculation process which determines energy losses...
While various peripheral blood stem cell (PBSC) mobilization strategies have been employed, granulocyte-colony stimulating factor (G-CSF) with or without plerixafor is widely utilized for its efficacy, safety and cost. To date, the recombinant G-CSF known as tbo-filgrastim has not compared to traditionally used filgrastim of PBSC engraftment after autologous transplantation (ASCT). Therefore, we sought compare efficacy cost during engraftment. Patients lymphoma plasma disorders undergoing...
Rationale: As the COVID-19 pandemic changes social landscape, distinguishing what is important to electronic (e)-cigarette users as well changing perceptions and behaviors informs research on current impact that e-cigarettes have communities. We designed study define how e-cigarette use has been impacted by COVID-19, changed user habits their risk perceptions. Methods: To assess perceptions, a nationally distributed 52-item questionnaire assessed use, dependence diagnosis, demographic data,...
Four patients with impotence as a result of radical cystectomy were treated mixture papaverine/phentolamine at 30:1 ratio, successful results.