A5013082973- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Endoplasmic Reticulum Stress and Disease
- Microbial Metabolic Engineering and Bioproduction
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- Biomedical and Engineering Education
- Viral Infections and Outbreaks Research
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Microbial metabolism and enzyme function
- Biofuel production and bioconversion
- Protein Structure and Dynamics
- interferon and immune responses
- Animal Disease Management and Epidemiology
German Center for Infection Research
2022-2023
Bernhard Nocht Institute for Tropical Medicine
2021-2023
University of Tübingen
2019-2021
Biology of Infection
2020
Abstract Motivation The novel coronavirus (SARS-CoV-2) currently spreads worldwide, causing the disease COVID-19. number of infections increases daily, without any approved antiviral therapy. recently released viral nucleotide sequence enables identification therapeutic targets, e.g. by analyzing integrated human-virus metabolic models. Investigations changed processes after virus and effect knock-outs on host can reveal new potential targets. Results We generated an host–virus genome-scale...
The current SARS-CoV-2 pandemic is still threatening humankind. Despite first successes in vaccine development and approval, no antiviral treatment available for COVID-19 patients. success further tarnished by the emergence spreading of mutation variants SARS-CoV-2, which some vaccines have lower efficacy. This highlights urgent need therapies even more. article describes how genome-scale metabolic model (GEM) host-virus interaction human alveolar macrophages was refined incorporating latest...
Nipah virus (NiV) is an emerging zoonotic paramyxovirus that causes severe disease in humans and livestock. Due to its high pathogenicity the lack of available vaccines therapeutics, NiV needs be handled biosafety level 4 (BSL-4) laboratories. Safe inactivation samples containing thus necessary allow further processing lower containment areas. To date, there only limited information on methods validated by BSL-4 facilities can used as a reference. Here, we compare some most common order...
Dolosigranulum pigrum is a quite recently discovered Gram-positive coccus. It has gained increasing attention due to its negative correlation with Staphylococcus aureus, which one of the most successful modern pathogens causing severe infections tremendous morbidity and mortality multiple resistances. As possible mechanisms behind inhibition S. aureus remain unclear, genome-scale metabolic model (GEM) enormous interest high importance better study role in this fight. This article presents...
The current SARS-CoV-2 pandemic is still threatening humankind. Despite first successes in vaccine development and approval, no antiviral treatment available for COVID-19 patients. success further tarnished by the emergence spreading of mutation variants SARS-CoV-2, which some vaccines are not effective anymore. This highlights urgent need therapies even more. article describes how Genome-Scale Metabolic Model (GEM) host-virus interaction human alveolar macrophages was refined incorporating...
Nipah virus (NiV) is a zoonotic paramyxovirus with fatality rate of up to 92% in humans. While several pathogenic mechanisms used by NiV counteract host immune defense responses have been described, all the processes that take place cells during infection are not fully characterized. Here, we describe formation ordered intracellular structures infection. We observed these formed specifically infection, but other viruses from same Mononegavirales order (namely Ebola virus) or orders such as...