Clinical and pathologic diagnoses are compared in 65 patients who had dementia been studied longitudinally during life. The sensitivity of diagnosis for the Alzheimer type (DAT) without any other was 87%, specificity 78%. ischemic scale score did not discriminate well between with pure multi-infarct those both DAT dementia. However, 35 38 cases a 4 or less on scale.

Leuko-araiosis was found in 49 of 140 demented patients compared with 12 out 110 control subjects. Thirty-one 95 dementia the Alzheimer's type had leuko-araiosis. A history stroke four times more frequent leuko-araiosis than those without (17.4% and 4.4%, respectively). It occurred 25% controls only 2% Mean systolic blood pressure associated No association for diastolic pressure, myocardial infarction, angina, diabetes, or carotid bruits. On logistic regression analysis, strong between...

The relationships between cerebral blood flow (CBF), arterial oxygen content, whole viscosity and the transport of to brain have been studied in 54 subjects with variations content resulting from alterations haemoglobin concentration ranging 5.7 19.1 g/dl. A highly significant relationship was found CBF altering maintain rate within certain limits. No effect changes evident. In a multiple regression analysis emerged as major determinant after this had taken into account there no influence...

Background: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient population remain suboptimal. Objectives: To evaluate the safety and efficacy of vaccines in individuals exposed to provide evidence-based clinical practice recommendations. Methods: A literature search patients (2009-2017) was conducted. Results were assessed using Grading Recommendation,...

Japanese neurosurgery in general and Sano's group particular has made a formidable contribution to the development of acute aneurysm surgery challenging con- ventional wisdom about timing ofoperation.In delightful preface, Professor Sano describes how first Shogun probably died on 13 January 1199 rebleed following an initial subarachnoid haemorrhage 31 December 1198, when he fell from his horse during opening ceremony for new bridge.Following brief introductory chapter that places various...

Cerebral blood flow (CBF) and the response to hypercapnia (cerebral reactivity) have been measured in 41 patients with unilateral or bilateral internal carotid artery occlusion an attempt identify those limited collateral reserve. Normocapnic CBF was within normal limits majority of subjects. The varied from absent, impaired reactivity becoming increasingly likely when more than one diseased. In 19 occlusion, hemisphere well preserved majority, but significantly lower on side (mean 2.9%/mm...

The present study was a randomized, parallel, double-blind comparison between controlled-release (CR) tramadol and sustained-release (SR) diclofenac in patients with chronic pain due to osteoarthritis of the hips and/or knees.

Cerebral blood flow and oxygen transport to the brain have been studied in 20 patients with primary polycythaemia, before after venesection. rose by an average of 30 per cent (P < 0.001) when mean haematocrit was reduced from 0.537 0.444. Whole viscosity fell predictably correlation coefficient between at a shear rate 91s−1was 0.926 0.001). Mean arterial pressure, PCO2 pH were not influenced A small but significant overall rise PO2 observed content reduction haemoglobin concentration. The...

Background and Purpose Regions of decreased cerebral blood flow are often seen on single-photon emission computed tomography (SPECT) after stroke have been widely reported to add the clinical deficit. However, such reports not distinguished between correlation causation. We analyzed 124 serial SPECT scans performed in 50 patients assess role diaschisis deficit stroke. Methods with use 99m Tc–hexamethylpropyleneamine oxime ( Tc-HMPAO) was a prospective, unselected series infarcts studied at...

The presenting characteristics of 74 patients with atherosclerotic occlusion both internal carotid arteries are described. All had suffered either ischaemic hemisphere infarcts (80%) and/or transient attacks involving one (78%) or (22%) territories. In addition, 10 subjects (14%) incurred recurrent vertebrobasilar presyncopal episodes, many which appeared secondary to haemodynamic insufficiency. incidence risk factors and concomitant vascular disease was high; 93% gave a history heavy...

Introduction– Despite the current interest in criteria for vascular dementia, global, as opposed to focal, cognitive change after cerebral infarction has rarely been studied. Material and methods– We documented neuropsychological changes one three weeks months post infarct 25 unselected patients with acute, first infarcts. Results– Improvements were seen processes thought have a large subcortical component those mediated right hemisphere. Memory was relatively lightly affected. Conclusion–...

Objective. To assess agreement and application of Treat to Target (T2T) recommendations in Canadian practice. Methods. A survey rheumatologists was conducted on the T2T, an international initiative toward reaching specific therapeutic goals rheumatoid arthritis. Agreement with each recommendation measured a 10-point Likert scale (1 = fully disagree, 10 agree). 4-point (never, not very often, always) assessed current Responders who answered “never” or “not often” were asked whether they...

The use of immunosuppressive therapies for immune-mediated disease is associated with an elevated risk infections and related comorbidities. While many infectious diseases can generally be prevented by vaccines, immunization rates in this specific patient population remain suboptimal, due part to uncertainty about their efficacy or safety under these clinical situations. To address concern, a multidisciplinary group Canadian physicians expertise dermatology, gastroenterology, diseases,...

The cerebral blood flow is low in primary polycythaemia, and it has been suggested that this due to the increase viscosity which accompanies elevated haematocrit. In present study measured by a non-invasive 133Xenon technique six subjects with an haematocrit secondary haemoglobin variant increased oxygen affinity. Flow was significantly higher than normal 81 % 11 of comparable age, matched for viscosity, but without variant. patients unusual type high despite implications these results are discussed.

Methotrexate (MTX) is often the primary medication to treat various rheumatic diseases (RDs) because of its low cost and demonstrated efficacy in controlling disease activity. However, a concern has been potential for hepatic fibrosis associated with long-term MTX usage. This study investigated association between cumulative intake development liver by utilizing noninvasive transient elastography (FibroScan).All patients inflammatory arthritis treated were offered screening FibroScan. A...

<h3>OBJECTIVE</h3> Little is known about the effect of spontaneous reperfusion human cerebral infarcts. Single photon emission computerised tomography (SPECT) data were analysed from a study using ⁹⁹Tc^m HMPAO (⁹⁹Tc^m hexamethylpropyleneamine oxime) in infarction for frequency and to see if it affected infarct size, oedema, haemorrhagic transformation, or functional outcome. <h3>METHODS</h3> Fifty sequential cases ischaemic stroke studied with 124...

A total of 1,377 patients with symptomatic obstructive cerebrovascular disease (most commonly, internal carotid artery occlusion) entered a trial in which they were randomized to either medical or surgical (extracranial-intracranial bypass) therapy. All but 8 had hemoglobin estimations performed at entry. The followed for an average 55.8 months. In the group, 325 high normal concentration (15 g/l more) suffered no more ischemic strokes than 382 lower values (less 15 g/l). Those that did...

Background Recently, many countries, including Canada, evaluated rheumatologists' acceptance and agreement with a set of 10 Treat to Target (T2T) recommendations for rheumatoid arthritis (RA), developed by an international task force. In this study, the Canadian T2T steering committee how patients RA perceive these recommendations. Objectives The objectives study were assess current state management in Canada from patient perspective whether what extent Canadians agree each compare results...

The concept of a General Practitioner with Special Interest (GPwSI) was first proposed in the 2000 National Health Service Plan, as way providing specialised treatment closer to patient's home and reducing hospital waiting times. Given patchy inadequate provision allergy services UK introduction GPwSIs might reduce pressure on existing specialist services. This study assessed what proportion referrals clinic could be managed GPwSI service predefined range facilities expertise (accurate...

Abstract Objective Adult‐onset Still's disease (AOSD) and secondary hemophagocytic lymphohistiocytosis (sHLH) are both hyperferritinemic cytokine storm syndromes that can be difficult to distinguish from each other in hospitalized patients. The objective of this study was compare the inflammatory markers ferritin, D‐dimer, C‐reactive protein (CRP), soluble CD25 (sCD25) patients with AOSD sHLH. These four were chosen as they widely available represent different aspects diseases: macrophage...

Background and Purpose The role of single-photon emission CT (SPECT) in the prognosis cerebral infarction is controversial, but most studies report that SPECT using a variety radiopharmaceutical agents gives useful prognostic information. Only one study has questioned whether acute perfusion deficits independently add to valid clinical score. This was limited middle artery territory infarcts negative. We present data on utility 99m Tc–hexamethylpropyleneamine oxime (HMPAO) infarction,...