Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-cysteinylglycine and the predominant intracellular antioxidant in many organisms including humans. GSH associated enzymes are controlled by transcription factor-nuclear factor-2 related erythroid (Nrf2). In cellular milieu, protects cells essentially against wide variety free radicals reactive oxygen species, lipid hydroperoxides, xenobiotic toxicants, heavy metals. It has two forms, form glutathione (GSH) oxidized...

Cinnamomum species are a group of plants belonging to the Lauraceae family. These predominantly used as spices in various food preparations and other culinary purposes. Furthermore, these attributed having cosmetic pharmacological potential. malabatrum (Burm. f.) J. Presl is an underexplored plant genus. The present study evaluated chemical composition by GC-MS analysis antioxidant properties essential oil from C. (CMEO). Further, effects were determined radical quenching, enzyme inhibition...

Infectious diseases and their vectors have remained a concern for human population from historical origin. Microbial pathogens also emerged as potent threat to the healthcare systems even in developed countries. Essential oils remain less explored method infectious disease control; besides, ultrasound-assisted extraction (UAE) of essential oil production has promising source bioactive volatiles over conventional methods. This study analyzed possible use UAE- (EOs) different species Ocimum...

Borassus flabellifer L., belonging to the Arecaceae family, is less explored for its nutritional and biological properties. The plant parts such as tender kernel, water, sap, haustorium are consumed by various communities in India. present study first time analyzed cytoprotective anti-inflammatory properties of extract (BHE). protective effect BHE was estimated normal intestinal epithelial cell (IEC-6) against pro-oxidant insults induced hydrogen peroxide (H2O2) malondialdehyde (MDA)....

Functional foods play important roles in the management of health; haustoria from Cocos nucifera and Borassus flabellifer are less explored for their nutritional benefits. Therefore, study evaluated proximate composition, biological anti-diabetic effects CH BH. The total polyphenol content coconut palmyra palm haustorium was conducted using standard Folin-Ciocalteu based assay. radical scavenging properties Coconut Palmyra analyzed by DPPH assay, Lipid peroxidation inhibition as well...

Abstract Citrus fruits have a thick outer coat which is often discarded due to its low economic value and usually contributes the waste. So this work focused on exploring potential pharmacological properties of citrus peels. In present study, we extracted essential oil from peel wastes reticulata Blanco (CREO) local market. The antioxidant, antibacterial, anticancer were evaluated. CREO exhibited strong antioxidant property with DPPH radical scavenging, ABTS H 2 O Ferric reducing power for...

Fluoride is the most common cause of drinking water-associated toxicity and known to induce various metabolic imbalances dental/skeletal fluorosis. The present study analyzed protective effect Borassus flabellifer Linn. haustorium extract (BHE) against fluoride-induced intestinal redox metabolism apoptosis. total polyphenols flavonoids in BHE were estimated be 39.67 ± 5.14 mg gallic acid equivalent/g 8.59 0.74 quercetin equivalent. In cultured epithelial cells (IEC-6), sodium fluoride...

Oxidative stress and inflammation are the predominant cause of chronic diseases, including multiple forms cancers. Prevention oxidative is considered to be a target for preventing these disorders due their significant roles in various degenerative diseases. Various natural products plant extracts prevent process free radical- induced damages. The present study evaluated biological properties Thottea siliquosa, belonging family Aristolochiaceae, which traditionally used Ayurvedic plant....

Plants have been employed in therapeutic applications against various infectious and chronic diseases from ancient times. Various traditional medicines folk systems utilized numerous plants plant products, which act as sources of drug candidates for modern medicine. Artemisia is a genus the Asteraceae family with more than 500 species; however, many these species are less explored their biological efficacy, several others lacking scientific explanations uses. nilagirica that widely found...

Aim The study was aimed to assess the ability of Borassus flabellifer haustorium methanolic extract (BHE) on de novo glutathione biosynthesis in normal and pro-oxidant exposed cells via Nuclear factor erythroid 2-related 2 (Nrf2) haeme oxygenase-1 (HO1) signaling 2,2′-Azobis(2-methylpropionamidine) di-hydrochloride (AAPH) induced cytotoxicity intestinal epithelial (IEC-6 cells).Methods vitro antioxidant activity determined terms radical scavenging ex vivo hemolysis. cytoprotective effect...

Gastric cancer (GC), with its high morbidity and mortality rates, emerged as an important health concern in developing countries. Intracellular lipid kinases such sphingosine kinase (SphK) play a pivotal role the onset progression of gastric cancers. Plant products essential oils are drug candidates against various The Allspice (Pimenta dioica) oil was extracted by hydro-distillation methods. anticancer activity estimated cells using MTT assay. expression SphK1 SphK2 genes were assessed...

Marine algae are important sources of nutritionally and pharmacologically products. Here in the study, nutritional composition biological activities a marine red Nitophyllum punctatum were assessed. The present study aimed to analyze effects N. punctatum. was collected, shade dried extracted using Soxhelet apparatus. elemental estimated Atomic Absorption Spectroscopy; anti-inflammatory effect determined Raw 264.7 macrophages. Genotoxicity assessed by standard methods Allium cepa root model....

Inflammation is a physiological condition that when unattended causes serious health concerns over the long term. Several phytocompounds have emerged as promising sources of anti-inflammatory agents. Thottea siliquosa traditional medicine for inflammatory and toxicity insults; however, this has not been scientifically confirmed. The purpose study to evaluate properties T. methanol leaf extract in mouse model. This investigates activities plant obtained from leaves (TSE) with focus on...

Cocos nucifera L is well-known for its edible and medicinal uses; multiple products from the different parts of plant are being used by various communities in India. A less explored product coconut haustorium, solid endosperm portion, which highly nutritious. The present study first time evaluated antioxidant, anti-inflammatory cytoprotective properties methanolic extract Coconut haustorium (CHE). effect CHE was hydrogen peroxide/malondialdehyde-induced toxicity IEC-6 (normal intestinal...

Abstract Background and Aim Oxidative stress inflammation are the predominant cause of chronic diseases including cancers, thereby making it as an essential target for preventing these disorders. Various natural products plants have been shown to prevent process free radical induced damages. The present study evaluated biological properties Thottea siliquosa, belonging family Aristolochiaceae, which is a traditionally used Ayurvedic plant. Experimental Procedure Antioxidant assays carried...