A5076134995- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- biodegradable polymer synthesis and properties
- Cancer, Lipids, and Metabolism
- Central Venous Catheters and Hemodialysis
- Adhesion, Friction, and Surface Interactions
- Mass Spectrometry Techniques and Applications
- Pericarditis and Cardiac Tamponade
- Hydrogels: synthesis, properties, applications
- Metabolomics and Mass Spectrometry Studies
- Viral Infections and Immunology Research
- Molecular Junctions and Nanostructures
- Caveolin-1 and cellular processes
- Efficiency Analysis Using DEA
- Chemotherapy-related skin toxicity
- Electrospun Nanofibers in Biomedical Applications
- Polymer Foaming and Composites
- Streptococcal Infections and Treatments
- Hemoglobinopathies and Related Disorders
- Polymer Surface Interaction Studies
- Cardiac Structural Anomalies and Repair
- Autoimmune and Inflammatory Disorders
Pfizer (United States)
2024
Roche (United Kingdom)
2020-2022
LDS Hospital
2021
Icahn School of Medicine at Mount Sinai
2021
The Ohio State University
2006-2021
Broad Institute
2020-2021
The Ohio State University Wexner Medical Center
2015-2021
Nationwide Children's Hospital
2021
Allegheny Health Network
2020
Mount Holyoke College
2019
Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the receptor, has resulted in better outcomes patients severe Covid-19 pneumonia case reports retrospective observational cohort studies. Data are needed from randomized, placebo-controlled trials.In this phase 3 trial, we randomly assigned who were hospitalized 2:1 ratio receive single intravenous...
Trials of tocilizumab in patients with severe COVID-19 pneumonia have demonstrated mixed results, and the role combination other treatments is uncertain. Here we evaluated whether plus remdesivir provides greater benefit than alone pneumonia. This randomized, double-blind, placebo-controlled, multicenter trial included hospitalized requiring > 6 L/min supplemental oxygen. Patients were randomly assigned (2:1 ratio) to receive 8 mg/kg or placebo intravenously ≤ 10 days remdesivir. The primary...
ABSTRACT BACKGROUND COVID-19 is associated with immune dysregulation and hyperinflammation. Tocilizumab an anti–interleukin-6 receptor antibody. METHODS Patients hospitalized severe pneumonia receiving standard care were randomized (2:1) to double-blinded intravenous tocilizumab 8 mg/kg or placebo. The primary outcome measure was clinical status on a 7-category ordinal scale at day 28 (1, discharged/ready for discharge; 7, death). RESULTS Overall, 452 patients randomized; the...
In COVACTA, a randomised, placebo-controlled trial in patients hospitalised with coronavirus disease-19 (COVID-19), tocilizumab did not improve 28-day mortality, but shortened hospital and intensive care unit stay. Longer-term effects of COVID-19 are unknown. Therefore, the efficacy safety beyond day 28 its impact on Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) clearance antibody response COVACTA were investigated.Adults Europe North America (N = 452) between April 3, 2020...
Bioresponsive polymers can enable the development of more effective drug delivery vehicles and medical materials. Acetal-modified polysaccharides allow pH-triggered solubility switching in a versatile manner, but prior work has been limited to combination acyclic alkoxyisopropyl cyclic isopropylidene acetals. We describe here preparation characterization spirocyclic acetal-modified dextran (SpAc-Dex), which comprises decorated with cyclopentyl, cyclohexyl, or cycloheptyl acetals (SpAc5-,...
ABSTRACT Polyunsaturated phospholipids are essential for multiple cellular functions; however, their uncontrolled peroxidation leads to ferroptosis. Here we describe p hotochemical a ctivation of membrane l ipid eroxidation (PALP), which uses localized laser pulses induce lipid photochemically. While PALP bypasses enzymatic requirements peroxidation, the resulting BODIPY-C11-based signal is largely correlated with local polyunsaturated phospholipid concentration on membranes. This technique...
192 Background: The Allegheny Health Network Cancer Institute (AHNCI) Medical Oncology is comprised of 19 infusion clinics located in the western Pennsylvania region. Safety quality assurance data revealed an extravasation rate 0.12% for vesicant anticancer therapies. A literature review identified a benchmark these extravasations to be 0.09% confirming that AHNCI had opportunity improve patient safety. Methods: multidisciplinary team with support from ASCO’s Quality Training Program was...
A previously healthy 8-month-old female presents to the emergency department (ED) with diarrhea and an unusual diaper rash. Her symptoms began 6 days prior fever congestion. She was initially diagnosed a viral upper respiratory infection bilateral otitis media prescribed cephalexin by her primary care physician. Two later, she developed painful Cephalexin changed cefdinir due concern for antibiotic-induced diarrhea. After 5 of treatment, antibiotics were discontinued. Before this...