A5056306853- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medication Adherence and Compliance
- Health Systems, Economic Evaluations, Quality of Life
- Mobile Health and mHealth Applications
- Heart Failure Treatment and Management
- Chronic Disease Management Strategies
- Astro and Planetary Science
- Pharmaceutical Practices and Patient Outcomes
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Diabetes and associated disorders
- Diabetes Management and Research
- Respiratory and Cough-Related Research
- Health Literacy and Information Accessibility
- Planetary Science and Exploration
- Pharmaceutical Economics and Policy
- Digital Mental Health Interventions
- Antibiotic Resistance in Bacteria
- Pancreatic function and diabetes
- Clinical practice guidelines implementation
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Healthcare Policy and Management
NHS Greater Glasgow and Clyde
2020-2023
Gartnavel General Hospital
2023
University of British Columbia
2023
William Osler Health System
2020-2021
Museum of Heilongjiang Province
2021
National Institute for Health and Care Excellence
2018-2020
University of Glasgow
2011-2019
New York University
2019
Indiana University – Purdue University Indianapolis
2012
Leeds Beckett University
2012
An imbalance between oxidants and antioxidants is proposed in smokers patients with airways diseases. We tested this hypothesis by measuring the Trolox equivalent antioxidant capacity (TEAC) of plasma levels products lipid peroxidation as indices overall oxidative stress. The TEAC was markedly reduced (0.66 +/- 0.07 mmol/L; mean SEM; n = 11), increased products, healthy chronic compared nonsmokers (1.31 0.10 mmol/L, 14, p < 0.001), an effect that exaggerated those who had smoked 1 h before...
BACKGROUND--Oxidant/antioxidant imbalance may occur in the lungs of patients with chronic obstructive pulmonary disease (COPD). Glutathione is an important extracellular and intracellular thiol oxidant lungs. These studies were carried out to determine effect N-acetyl cysteine on concentrations plasma, bronchoalveolar lavage fluid, lung tissue. METHODS--Studies normal subjects, COPD, those undergoing resection. In first study was given three groups; healthy subjects (600 mg once daily by...
Research Article| December 01, 2012 Urban Geochemistry and Human Health Gabriel M. Filippelli; Filippelli 1Department of Earth Sciences Center for Health, Indiana University–Purdue University (IUPUI)723 W. Michigan Street, Indianapolis, IN 46202, USAE-mail: gfilippe@iupui.edu2Richard Fairbanks School Public HealthIndiana 46202USA Search other works by this author on: GSW Google Scholar Deborah Morrison; Morrison gfilippe@iupui.edu Domenico Cicchella 3Department Biological, Geological...
Background Chronic obstructive pulmonary disease (COPD) is common, and a major cause of morbidity mortality worldwide. Recent studies suggest that comorbidities COPD increase the risk hospitalisation, polypharmacy, mortality, but their estimated prevalence varies widely in literature. Aim To evaluate 38 physical mental health people with COPD, compare findings those for without large nationally representative dataset. Design setting A cross-sectional data analysis on 1 272 685 adults...
Glucocorticoids, also known as steroids, are a class of anti-inflammatory drugs utilised widely in clinical practice for variety conditions. They associated with range side effects including abnormalities glucose metabolism. Multiple guidelines have been published to illustrate best management glucocorticoid-induced hyperglycaemia and diabetes settings. This article discusses current diagnosis, investigations ongoing dysglycaemia both in- outpatient
The term multimorbidity is usually defined as the coexistence of two or more chronic conditions within an individual, whereas comorbidity traditionally describes patients with index condition and one additional conditions. Multimorbidity markedly worsens outcomes in patients, increases treatment burden health service costs. Although respiratory disease often have physical comorbidities, they also commonly experience psychological problems such depression anxiety. associated increased...
Objective To evaluate the feasibility of a phase 3 randomised controlled trial (RCT) website (Living Well with Asthma) to support self-management. Design and setting Phase 2, parallel group, RCT, participants recruited from 20 general practices across Glasgow, UK. Randomisation through automated voice response, after baseline data collection, access for minimum 12 weeks or usual care. Participants Adults (age≥16 years) physician diagnosed, symptomatic asthma (Asthma Control Questionnaire...
Polymorphonuclear neutrophils (PMN) have been implicated in the pathogenesis of emphysema. The chemokines interleukin-8(IL-8), growth-related oncogene (GRO-alpha) and extractable nuclear antigen (ENA)-78 may be involved increased numbers PMN smokers' airspaces. levels these cytokines bronchoalveolar lavage fluid (BALF) leukocyte conditioned medium (LCM), along with BALF 12 smokers who abstained for h (chronic smoking) or continued to smoke until I before study (acute seven nonsmokers were...
BACKGROUND--Since 1989 long term oxygen therapy (LTOT) in Scotland has been prescribable only by respiratory physicians, whereas England and Wales general practitioners can also prescribe this treatment. The effect of policy audited. METHOD--Six hundred thirty patients were prescribed LTOT between 1 October 30 September 1991, which 519 case notes reviewed. RESULTS--In 79% the diagnosis was chronic obstructive pulmonary disease (COPD), with a near equal male to female ratio. mean (SD) age 65...
Aim-To investigate cytochrome P4501A1 (CYP1A1) polymorphism and susceptibility to emphysema lung cancer.Methods-A novel polymerase chain reaction (PCR) for genotyping the CYP1A1 polymorphism, corresponding putative low or high enzyme activity, was developed genotype cancer resection samples which had been assessed macroscopically presence of centriacinar panacinar emphysema. Samples were collected genotyped from a group patients with chronic obstructive airways disease. A control anonymous...
Around 300 million people worldwide have asthma and prevalence is increasing. Self-management can be effective in improving a range of outcomes cost effective, but underutilised as treatment strategy. Supporting optimum self-management using digital technology shows promise, how best to do this not clear. We aimed develop an evidence based, theory informed, online resource support adults with asthma, called 'Living well Asthma', part the RAISIN (Randomized Trial Asthma Internet...
The financial costs associated with asthma care continue to increase while remains suboptimal. Promoting optimal self-management, including the use of action plans, along regular health professional review has been shown be an effective strategy and is recommended in guidelines internationally. Despite evidence benefit, guided self-management underused, however potential for online resources promote behaviors gaining increasing recognition. aim this paper describe protocol a pilot evaluation...