A5012237326- Receptor Mechanisms and Signaling
- Mass Spectrometry Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Heat shock proteins research
- Bacterial Genetics and Biotechnology
- Porphyrin Metabolism and Disorders
- Synthesis and bioactivity of alkaloids
- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Biochemical and Structural Characterization
NYU Langone Health
2021-2022
New York University
2022
University of Arizona
2018-2020
Antimicrobial peptides (AMPs) are generally cationic and amphipathic that show potential applications to combat the growing threat of antibiotic resistant infections. AMPs known interact with bacterial membranes, but their mechanisms toxicity selectivity poorly understood, in part because it is challenging characterize AMP oligomeric complexes within lipid bilayers. Here, we used native mass spectrometry measure stoichiometry inserted into lipoprotein nanodiscs different components....
Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated set SS analogs, each optimized to elicit specific systemic effects in prey. The increased metabolic stability, distinct receptor activation profiles, and chemical diversity the venom analogs make them suitable leads for therapeutic application, including pain, cancer, endocrine disorders. Our findings not...
Abstract Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated set SS analogs, each optimized to elicit specific systemic effects in prey. The increased metabolic stability, distinct receptor activation profiles, and chemical diversity the venom analogs make them suitable leads for therapeutic application, including pain, cancer endocrine disorders. Our...