A5066132503- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Glutathione Transferases and Polymorphisms
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Diabetes and associated disorders
- Pharmacogenetics and Drug Metabolism
- Cervical Cancer and HPV Research
- Helicobacter pylori-related gastroenterology studies
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Genomic variations and chromosomal abnormalities
- Cancer therapeutics and mechanisms
- Colorectal Cancer Screening and Detection
- Urticaria and Related Conditions
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Systemic Lupus Erythematosus Research
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Veterinary medicine and infectious diseases
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
Shri Maharaja Hari Singh Hospital
2020-2022
Government Medical College
2020-2022
Weatherford College
2021
Sher-i-Kashmir Institute of Medical Sciences
2011-2019
University of Kashmir
2014-2019
Institute of Medical Sciences
2016
Gynecological cancers (GCs) affect the reproductive system of females, and are multiple types depending on affected organ most common which cervical, endometrial, ovarian cancers. Among different risk factors for GCs, ABO blood group is considered as one pivotal contributing increased susceptibility GCs. The aim our study was to report demographics GC patients investigate relationship between acquiring in population. current retrospective cross-sectional carried out years 2016 2023. sample...
Skin prick test (SPT) is the most effective diagnostic to detect IgE mediated type I allergic reactions like rhinitis, atopic asthma, acute urticaria, food allergy etc. SPTs are done know sensitivity and applied for devising immunotherapy as therapeutic modality.This prospective study was conducted in department of Immunology Molecular medicine at SKIMS. A total 400 patients suffering from asthma urticaria were recruited this study. SPT performed with panel allergens including house dust...
Several studies suggest that Vitamin D (Vit-D3) supplementation reduces Chronic Urticaria (CU) symptoms.Evaluation of serum 25-hydroxyvitamin-D (25 (OH)2D) level and assessment therapeutic effect VitD3in CU patients.192 subjects were stratified according to the baseline 25(OH)2D levels subsequently randomized into three subgroups receive Vit-D3 alone (VD) or antihistamine systemic corticosteroid (H+S) VitD3 with (VD+H+S) for 6 weeks between July 2012 Oct 2014. 130 healthy controls (HC)...
MTHFR C677T polymorphism and colorectal cancer 68.6, 20.9 10.4% among cases 75.6, 16.9 7.5% the general control population, respectively.There was a significant association between TT genotype in higher age group.We conclude that slightly increases risk for development our ethnic Kashmir population.
The aim of this study was to investigate the role XRCC1 Arg399Gln polymorphism in susceptibility a Kashmiri population colorectal cancer (CRC). We investigated genotype distribution gene 130 CRC cases comparison with that 150 healthy subjects. There no direct significant association between genotypes and CRC; however, Arg/Gln associated an elevated risk (OR>1.47) Gln/Gln variant increased various clinicopathological parameters. This suggests is CRC.
Cytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim this study was to determine whether CYP450 polymorphisms are associated with risk colorectal cancer (CRC). We investigated genotype distribution CYP2E1 gene RsaI 96-base pair (bp) insertion 86 CRC cases comparison 160 healthy subjects. found frequency be 53.5 per cent (46/86) for c1/c1, 17.4 (15/86) c1/c2 29.1...
Glutathione S-transferases (GSTs) are enzymes detoxifying a wide range of hazardous substances both endogenous or exogenous origin, such as reactive oxygen species (ROS) xenobiotics and environmental carcinogens; thereby imparting protection to DNA against oxidative damage. GST gene polymorphisms on the other hand, exert an effect functioning encoded by these genes at expression level activity protein. In this way it may influence possibility detoxification carcinogens, consequently, damage;...
8-Oxoguanine DNA glycosylase (OGG1) is one of the important base excision repair enzymes that 8-oxoguanine lesion incorporated within an individual by reactive oxygen species. The aim this study was to detect role OGG1 Ser326Cys polymorphism in susceptibility colorectal cancer (CRC) a Kashmiri population. We investigated genotype distribution gene 114 CRC cases comparison with 200 healthy subjects. There no significant association between and CRC, but homozygous Cys/Cys variant associated...
XRCC (X-ray cross-complementing group) genes contribute to important DNA repair mechanisms that play roles in the of single strand breaks (SSBs) induced by a variety external and internal factors, including ionizing radiation, alkylating agents reactive oxygen species. These have pivotal role maintaining genomic stability through different pathways base excision (BER). The aim this study was investigate XRCC3 Thr241Met gene polymorphism colorectal cancer (CRC) Kashmir. We investigated...
The present study aimed to analyse the role of cyclin D1 A870G polymorphism in modulating susceptibility colorectal cancer (CRC) Kashmiri population. genotype distribution gene 130 CRC cases comparison with 160 healthy controls was investigated. No direct significant association between genotypes and observed; however, AG AA were found be associated an increased risk compared GG genotype, almost 2-fold increase OR. This suggests that is
RAD51 - a DNA double-strand breaks repair gene plays an important role in homologous recombination, process frequently involved cancer transformation. The aim of this study was to compare the distribution genotype G135C polymorphism between colorectal (CRC) patients and controls. We also tested association risk CRC, various clinicopathological parameters. Polymorphism evaluated by restriction fragment length PCR 100 CRC 120 age-matched sex-matched There significant genotypes cases (P<0.05)....
Genetic polymorphisms in DNA repair genes may influence individual variation capacity, which be associated with risk of developing cancer. For colorectal cancer the importance mutations mismatch has been extensively documented.In this study we focused on Arg194Trp polymorphism gene XRCC1, involved base excision (BER) and its role Kashmiri population. A case-control was conducted including 100 cases cancer, hospital-based age- sex-matched healthy controls to examine XRCC1 genetic context for...
Colorectal carcinogenesis has been found to be associated with the polymorphic status of Toll-like receptor 4 gene in various populations world. The aim study was determine genetic association TLR4 polymorphisms (Asp299Gly and Thr399Ile) disease susceptibility risk development colorectal cancer (CRC) patients Kashmir, India. Genotype frequencies were compared between 120 CRC 200 healthy controls using PCR-RFLP method. We did not find any significant cases (p > 0.05). However CT genotype...