A5046084104- TGF-β signaling in diseases
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Renal and related cancers
- Bone health and treatments
- Bone Metabolism and Diseases
- Cardiac Ischemia and Reperfusion
- Heterotopic Ossification and Related Conditions
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- Bone Tissue Engineering Materials
- Lipoproteins and Cardiovascular Health
- Bone and Joint Diseases
- Organ Transplantation Techniques and Outcomes
- Dental Implant Techniques and Outcomes
- Cytokine Signaling Pathways and Interactions
- Bone and Dental Protein Studies
- Liver physiology and pathology
- Spinal Cord Injury Research
- Inflammatory Bowel Disease
- Vitamin D Research Studies
- Medical Imaging and Pathology Studies
- Dental Radiography and Imaging
- Circular RNAs in diseases
- Pharmacological Effects and Toxicity Studies
University of Rijeka
2011-2024
Centre Hospitalier Universitaire Amiens-Picardie
2019
Inserm
2015-2019
University of Zagreb
2009
Herein we have demonstrated that both superoxide dismutase (SOD) mimic, cationic Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin (MnTnHex-2-PyP(5+)), and non-SOD anionic meso-tetrakis(4-carboxylatophenyl)porphyrin (MnTBAP(3-)), protect against oxidative stress caused by spinal cord ischemia/reperfusion via suppression of nuclear factor kappa B (NF-κB) pro-inflammatory pathways. Earlier reports showed N-alkylpyridylporphyrins were able to prevent the DNA binding NF-κB in an aqueous...
Beyond stimulating bone formation, morphogenetic proteins (BMPs) are important in development, inflammation, and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory, antiproliferative effect on experimental inflammatory bowel disease (IBD) rats. To further investigate BMP signaling pathway we monitored therapy components rat colon during different stages experimentally induced colitis by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The results...
Bone morphogenetic protein-9 (BMP-9) is a member of the transforming growth factor beta (TGF-β) superfamily cytokines, which regulate cell and differentiation during embryogenesis. Apart that, hypoglycemic potential BMP-9 great interest. It has been confirmed that BMP-9, like insulin, improves glycemia in diabetic mice regulates directional glucose metabolism hepatocytes; therefore it proposed to be candidate hepatic insulin-sensitizing substance (HISS). In liver fibrosis, due portocaval...
Tetralogy of Fallot is the most common cyanotic congenital heart disease. This severe disorder cardiac physiology can impair renal function and lead to development cardiorenal syndrome eventually end-stage Kidney transplantation may be best option for replacement treatment in patients with tetralogy Fallot, but only after correcting abnormalities optimizing functions, all which require a multidisciplinary approach. We report first case kidney an adolescent patient Fallot. Our findings...
<i>Introduction:</i> Bone morphogenetic proteins (BMPs) have been studied in several cancers, but only limited information is available about renal cell carcinomas (RCCs). We determined the expression of mRNA BMP ligands and receptors (BMPRs) healthy kidney tissue RCCs, data were compared to clinicopathological parameters. <i>Material Methods:</i> Sixty-four samples RCCs tissues prospectively examined. The BMP2, BMP4, BMP6, BMP7, BMPRIA, BMPRIB BMPRII was using...
Objective: Restenosis is a frequent complication of angioplasty. It consists neointimal hyperplasia resulting from progression and migration vascular smooth muscle cells (VSMC) into the vessel lumen. microRNA miR-223 has recently been shown to be involved in cardiovascular diseases including atherosclerosis, calcification arterial thrombosis. In this study, our aim was assess impact modulation on restenosis rat model carotid artery after balloon injury. Methods: The over down-expression...
Anatomy is a dynamic and translational discipline that integrates research education. Throughout the centuries, anatomical knowledge has become increasingly important for medical sciences, especially surgery. Cadaver dissection remains an irreplaceable met-hod acquiring comprehensive detailed understanding of human anatomy, as it only method enables safe effective clinical practice. The teaching anatomy evolved from traditional teachings to modern approaches. Scientific progress societal...
Vascular calcifications (VC) are increasingly prevalent in patients with chronic kidney disease. This study aimed to assess the incidence of iliac artery transplant (KT) and explore relationship between VC burden measured by pelvic calcification score (PCS) renal outcomes.