A5041591151- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Extracellular vesicles in disease
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Cardiac Valve Diseases and Treatments
- Pancreatic function and diabetes
- interferon and immune responses
- Aortic aneurysm repair treatments
- Parathyroid Disorders and Treatments
- Infant Nutrition and Health
- Erythrocyte Function and Pathophysiology
- Bone and Joint Diseases
- Erythropoietin and Anemia Treatment
- Bone Metabolism and Diseases
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- Helicobacter pylori-related gastroenterology studies
- CRISPR and Genetic Engineering
- Cardiovascular Disease and Adiposity
- RNA and protein synthesis mechanisms
- Hemoglobinopathies and Related Disorders
Inserm
2015-2024
Université Sorbonne Paris Nord
2014-2024
Laboratoire de Recherche Vasculaire Translationnelle
2016-2024
Université de Picardie Jules Verne
2014-2023
Hématopoïèse et immunologie
2016-2023
Sorbonne Université
1991-2023
Sorbonne Paris Cité
2013-2020
Université Paris Cité
2002-2020
Centre Hospitalier Universitaire Amiens-Picardie
2011-2019
Association pour la Recherche en Physiologie de l’Environnement
2016-2018
Backgound An elevated serum inorganic phosphate (Pi) level is a major risk factor for kidney disease and downstream vascular complications. We focused on the effect of Pi levels human aortic smooth muscle cells (VSMCs), with an emphasis role microRNAs (miRNAs). Methodology/Principal Findings Exposure primary VSMCs in vitro to pathological increased calcification, migration rate concomitantly reduced cell proliferation amount actin cytoskeleton. These changes were evidenced by significant...
Abstract Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR measure serum levels of miR-126 miR-223 in a large cohort 601 CKD patients (CKD stage G1 G5 or on renal replacement therapy – G5D) from Ghent University Hospital 31 healthy controls. All-cause mortality events were registered as endpoints over 6 year...
Morphology and changes in gene expression of vascular endothelium are mainly due to shear stress inflammation. Cell phenotype modulation has been clearly demonstrated be controlled by small noncoding micro-RNAs (miRNAs). This study focused on the effect laminar (LSS) human endothelial cells (HUVECs), with an emphasis role miRNA-126 (miR-126). Exposure HUVECs vitro LSS modified shape concomitantly regulated miR-126, cell adhesion molecule 1 (VCAM-1), syndecan-4 (SDC-4). A significant...
Genetic changes have been shown to be important in determining the multistep progression of cancer. Allele loss studies and karyotypic analysis epithelial ovarian tumours indicated presence putative tumour suppressor genes on chromosomes 6, 11, 13, 17, 18, 22, X. We focused chromosome arm 6q identify minimal region that may contain a gene. Nineteen polymorphic microsatellite markers from one centromeric marker (D6S294) used detect allele 68 (six benign, six borderline, 56 with malignant...
Cholecystokinin (CCK)/gastrin receptors were characterized in calf pancreatic plasma membranes from newborns, 28- and 119-day-old milk-fed preruminants, weaned ruminants. Scatchard analysis of [125I]Bolton-Hunter reagent-[Thr28,Nle31]CCK-(25-33) binding indicated two classes sites: high affinity sites exhibited significant higher capacity (P < 0.05) ruminants than preruminants (Kd = 0.13 +/- 0.02 vs. 0.35 0.08 nM; (Bmax) 53 12 18 5 fmol/mg protein). Pharmacological using selective agonists...
The aim of the present review is to synthesise and summarise our recent knowledge on involvement cholecystokinin (CCK) gastrin peptides their receptors in control digestive functions more generally role field nutrition mammals. First, we examined release these from gut, focusing molecular forms, factors regulating signalling pathways mediating effects. Second, general physiological effects CCK are described with regard specific vagal mucosal afferent nerve activities. Local gut also...
Abstract Atherosclerosis, in the ultimate stage of cardiovascular diseases, causes an obstruction vessels leading to ischemia and finally necrosis. To restore vascularization tissue regeneration, stimulation angiogenesis is necessary. Chemokines microRNAs (miR) were studied as pro‐angiogenic agents. We analysed miR‐126/CXCL12 axis compared impacts both miR‐126‐3p miR‐126‐5p strands effects CXCL12‐induced angiogenesis. Indeed, two miR‐126 previously shown be active but never together same...
Chronic kidney disease (CKD) is a major cause of death worldwide and associated with high risk for cardiovascular all-cause mortality. In CKD, endothelial dysfunction occurs uremic toxins accumulate in the blood. miR-126 regulator its blood level decreased CKD patients. order to obtain better understanding physiopathology disease, we correlated levels several markers dysfunction, as well representative toxins, large cohort patients at all stages disease. Using univariate analysis, found...