A5008575761- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Prosthetics and Rehabilitation Robotics
- Music Therapy and Health
- Heart Rate Variability and Autonomic Control
- Advanced Memory and Neural Computing
- Cardiac, Anesthesia and Surgical Outcomes
- Climate Change and Health Impacts
- Motor Control and Adaptation
- Eating Disorders and Behaviors
- Photoreceptor and optogenetics research
- Pain Management and Treatment
- Airway Management and Intubation Techniques
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Music Perception
- Neural and Behavioral Psychology Studies
- Diverse Music Education Insights
- Functional Brain Connectivity Studies
Massachusetts Institute of Technology
2020-2025
Human Media
2024
Athinoula A. Martinos Center for Biomedical Imaging
2020-2022
Harvard University
2022
Massachusetts General Hospital
2020-2022
Abstract For centuries scientists and technologists have sought artificial leg replacements that fully capture the versatility of their intact biological counterparts. However, gait requires coordinated volitional reflexive motor control by complex afferent efferent neural interplay, making its neuroprosthetic emulation challenging after limb amputation. Here we hypothesize continuous a bionic can restore biomimetic below-knee amputation when residual muscle afferents are augmented. To test...
Implantable biohybrid systems with computer-controlled actuation offer the capacity to modulate biological forces, but require biocompatible, self-sustaining, and scalable actuators. Repurposing muscles can fulfill this need. However, muscle fatigue limits fundamental capabilities of muscle-actuated systems. Here we present a fatigue-resistant myoneural actuator (MNA) engineered recruitment biophysics in rodent model. The MNA is based on manipulating native axonal composition through sensory...
Agonist-antagonist myoneural interfaces in lower-limb amputation help preserve sensory feedback to the brain.
Closed-loop neuroprostheses show promise in restoring motion individuals with neurological conditions. However, conventional activation strategies based on functional electrical stimulation (FES) fail to accurately modulate muscle force and exhibit rapid fatigue because of their unphysiological recruitment mechanism. Here, we present a closed-loop control framework that leverages physiological modulation under optogenetic (FOS) enable high-fidelity for extended periods time (>60 minutes)...
Significance Despite advancements in prosthetic technologies, persons with amputation today suffer great diminution mobility and quality of life. This is largely due to an outdated paradigm that precludes efficacious communication between the residual limb prosthesis. An method utilizing agonist–antagonist myoneural interfaces (AMIs) constructs neuromuscular substrates avail enhanced sensorimotor signaling. In our study, subjects AMI demonstrate improved motor control, phantom sensations,...
The agonist-antagonist myoneural interface (AMI) is an amputation surgery that preserves sensorimotor signaling mechanisms of the central-peripheral nervous systems. Our first neuroimaging study investigating AMI subjects conducted by Srinivasan et al. (2020) focused on task-based neural signatures, and showed evidence proprioceptive feedback to central system. resting state activity helps non-invasively characterize patterns prime task response. In this functional magnetic resonance imaging...
For persons with lower extremity (LE) amputation, acquisition of surface electromyography (sEMG) from within the prosthetic socket remains a significant challenge due to dynamic loads experienced during gait cycle. However, these signals are critical for both understanding clinical effects LE amputation and determining desired control trajectories active prostheses. Current solutions collecting within-socket sEMG generally (i) incompatible subject's prescribed liners, (ii) uncomfortable,...
Elucidating underlying mechanisms in subject-specific motor control and perception after amputation could guide development of advanced surgical neuroprosthetic technologies. In this study, relationships between preserved agonist-antagonist muscle strain within the residual limb capacity are investigated.
Music is a powerful tool for managing negative affect, due to its portability, accessibility, and unique ability impact mood. In an effort explore uses of personalized music as anxiety management intervention, we designed interface featuring 14 novel musical fragments with adjusted tempo, instrumentation, rhythm allowed users navigate freely. We conducted pilot study test the efficacy this approach reducing stress anxiety. Through survey biometric data, found that our can effectively reduce...
Srinivasan, Shriya S. PhD; Herr, Hugh M. Clites, Tyler R. Gutierrez-Arango, Samantha BS; Teng, Ashley; Beltran, Luis MD; Song, Hyungeun MS; Israel, Erica Carty, Matthew J. MD Author Information
ABSTRACT Introduction Scarcity of operating rooms and personal protective equipment in far-forward field settings make surgical infections a potential concern for combat mortality morbidity. Surgical transport personnel also face infectious risks from bodily fluid exposures. Our study aimed to describe the serial, proof-of-concept testing SurgiBox technology: an inflatable sterile environment that addresses aforementioned problems, fits on gurneys backpacks, drapes over incisions. Materials...
Abstract The relationship between motor cortex (M1) and upper limb movements has been investigated extensively using functional MRI (fMRI). While most research focused on applications, very few studies have practical aspects related to developing the fMRI protocol. Thus, effect of scan length M1 activations during various remains unclear. Scan constraints are important for conducting experiments within a 60- or 90-min session. We targeted this gap by studying 7T in male participant while...
Maladaptive cerebral neuroplasticity is a well-established consequence of limb amputation. However, little known about the potentially causal role neuromuscular feedback in preserving cortical and subcortical structures essential for sensation motor planning, or modulating phantom pain. In this investigation, we study impact agonist-antagonist myoneural interface (AMI) amputation procedure, which preserves proprioceptive feedback, on reorganization. We perform neuroimaging subjects with AMI...
Cardiac responses to appetitive stimuli have been studied as indices of motivational states and attentional processes, the former being associated with cardiac acceleration latter deceleration. Very few studies examined heart rate changes in classical conditioning humans. The current study describes development pilot testing a task assess cues that reliably precede them. Data from 18 adults were examined. They shown initially neutral visual (putative CS) on computer screen followed by...