A5054559777- Spine and Intervertebral Disc Pathology
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Cervical and Thoracic Myelopathy
- Artificial Intelligence in Healthcare and Education
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Bone Tumor Diagnosis and Treatments
- Fatigue and fracture mechanics
- Radiology practices and education
- Soft tissue tumor case studies
- Spinal Hematomas and Complications
- Pituitary Gland Disorders and Treatments
- Reliability and Maintenance Optimization
- Software Engineering Techniques and Practices
- Soft tissue tumors and treatment
- Neural and Behavioral Psychology Studies
- Child and Animal Learning Development
- Genetic Neurodegenerative Diseases
- Action Observation and Synchronization
- Behavioral and Psychological Studies
- Enhanced Recovery After Surgery
Harvard University
2015-2025
Massachusetts General Hospital
2015-2025
Massachusetts Institute of Technology
2024
INC Research (United States)
1963
Laboratoire de Chimie
1963
Kirtland Air Force Base
1953
Abstract For centuries scientists and technologists have sought artificial leg replacements that fully capture the versatility of their intact biological counterparts. However, gait requires coordinated volitional reflexive motor control by complex afferent efferent neural interplay, making its neuroprosthetic emulation challenging after limb amputation. Here we hypothesize continuous a bionic can restore biomimetic below-knee amputation when residual muscle afferents are augmented. To test...
INTRODUCTION: Neural prosthetic interfaces represent a promising therapeutic modality for patients who have experienced loss of extremity function from traumatic brain injury, stroke, spinal cord injury or limb amputation. Proprioception—an essential fine motor control, trajectory planning, and gait—remains challenging to restore within current neural strategies as existing approaches rely on non-naturalistic afferent feedback delivered via off-target sensory pathways. The agonist-antagonist...
Implantable biohybrid systems with computer-controlled actuation offer the capacity to modulate biological forces, but require biocompatible, self-sustaining, and scalable actuators. Repurposing muscles can fulfill this need. However, muscle fatigue limits fundamental capabilities of muscle-actuated systems. Here we present a fatigue-resistant myoneural actuator (MNA) engineered recruitment biophysics in rodent model. The MNA is based on manipulating native axonal composition through sensory...
OBJECTIVE Optimal diagnosis and management strategies for intradural spinal arachnoid cysts (SACs) are still unresolved given the rare nature of this entity, with few large case series virtually no statistical analyses patient characteristics in literature. Here, authors studied a cohort these lesions to determine whether pre- or postoperative attributes could be used aid either prognosis. METHODS A chart review was completed at single institution period from 2002 2016 preoperative outcomes...
Motor deficit is among the most debilitating aspects of injury to central nervous system. Despite ongoing progress in brain-machine interface (BMI) development and functional electrical stimulation muscles nerves, little understood about how neural signals brain may be used potentially control movement one's own unconstrained paralyzed limb. We recorded from high-density electrocorticography (ECoG) electrode arrays ventral premotor cortex (PMv) a rhesus macaque real-time motion tracking...
Machine learning (ML)-based predictive models are increasingly common in neurosurgery, but typically require large databases of discrete variables for training. Natural language processing (NLP) can extract meaningful data from unstructured text.To present an NLP model that predicts nonhome discharge and a point-of-care implementation.We retrospectively collected age, preoperative notes, radiology reports 595 adults who underwent meningioma resection academic center 1995 to 2015. A total 32...
Long-term memory is a core aspect of human learning that permits wide range skills and behaviors often important for survival. While this ability has been broadly observed procedural declarative memory, whether similar mechanisms subserve basic sensory or perceptual processes remains unclear. Here, we use visual paradigm to show training humans search common features in the environment leads persistent improvement performance over consecutive days but, surprisingly, suppresses subsequent...
BACKGROUND: Cervical fusion surgery is associated with adjacent-level degeneration, but surgical and technical factors are difficult to dissociate from the mechanical effects of itself. OBJECTIVE: To determine effect on degeneration in unoperated patients using a cohort congenitally fused cervical vertebrae. METHODS: We identified 96 incidental single-level congenital computed tomography imaging. compared these an age-matched control 80 without fusion. quantified through direct measurements...
INTRODUCTION: Hemangioblastoma is a rare benign neoplasm that accounts for 2-5% of all spinal cord tumors and associated with von-Hippel Landau (VHL) disease in about 25-30% patients. Symptomatic hemangioblastomas are typically managed en bloc microsurgical resection, but the infrequent nature these lesions has limited detailed characterization reported management surgical outcomes literature. METHODS: We retrospectively reviewed patients pathology-proven hemangioblastoma. collected...
BACKGROUND AND OBJECTIVES: Spastic equinovarus foot (SEF) is a common complication of stroke and other upper motor neuron injuries. It characterized by plantigrade inverted foot, often with toe curling, causing significant disability from pain, gait, balance difficulties. Management includes physical therapy, antispasticity drugs, orthoses, chemical neurolysis, or botulinum toxin, all which may be insufficient, sedating, transient. Selective tibial neurotomy (STN) provides surgical option...
Pediatric spinal cord glioblastoma multiforme is a rare entity with poor prognosis often presenting lower extremity weakness or paralysis. Previous literature suggests that aggressive surgical resection may provide overall survival benefit; however, there limited concurrent analysis demonstrating neurological recovery following resection. We report the case of 9-year-old boy who presented complete paraplegia and regained ability to ambulate independently subtotal resection, radiation,...
Abstract INTRODUCTION Social dysfunction is among the most prominent features of autism spectrum disorder (ASD) as well many other developmental and neuropsychiatric conditions. What precise neuronal mechanisms are disrupted in ASD, however, unknown. The goal this study to provide a basic cellular-level understanding treatment model for ASD. METHODS We developed an alternating appetitive/aversive paradigm which socially-paired mice experienced both acute stress food reward while we...