A5067930787- Antioxidants, Aging, Portulaca oleracea
- Magnesium Alloys: Properties and Applications
- Metal and Thin Film Mechanics
- Software Reliability and Analysis Research
- Mesenchymal stem cell research
- Adaptive Control of Nonlinear Systems
- Aluminum Alloys Composites Properties
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Hydrogen's biological and therapeutic effects
- Aluminum Alloy Microstructure Properties
- Adaptive Dynamic Programming Control
- Heavy Metal Exposure and Toxicity
- Ginseng Biological Effects and Applications
- Advanced materials and composites
- Tryptophan and brain disorders
- Stability and Control of Uncertain Systems
- Medicinal Plants and Bioactive Compounds
- Mitochondrial Function and Pathology
- Reinforcement Learning in Robotics
- Software Engineering Research
- Inflammasome and immune disorders
- Software Testing and Debugging Techniques
- Advanced ceramic materials synthesis
- Surface Treatment and Coatings
South China University of Technology
2024
Chongqing Population and Family Planning Science and Technology Research Institute
2022-2024
East China University of Technology
2022-2023
Nanjing University of Aeronautics and Astronautics
2020-2023
University of California, Berkeley
2021
Sichuan University
2020
Chongqing Medical University
2016-2019
Jiangsu University
2019
Nankai University
2016
State Key Laboratory of Medicinal Chemical Biology
2016
Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupling" mitochondrial dynamics mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif initiate in mammalian cells. Here, we show interacts with both DNM1L/DRP1 OPA1 coordinate or mitophagy. interacted via Lys70 (K70) residue, mutation K70 Ala (A), but not Arg (R),...
The evolution mechanism of the microstructure and mechanical properties a Mg-Y-Nd-Gd-Zr alloy subjected to different numbers passes ultrasonic surface rolling process (USRP) was investigated. results demonstrated an initial decrease followed by increase in roughness alloy. optimal achieved after four passes, with contour mean deviation 0.06 μm micro-roughness 10-point height 0.55 μm. After USRP, exhibited composite gradient structure characterized increased grain size decreased dislocation,...
Stem cell senescence is an important and current hypothesis accounting for organismal aging, especially the hematopoietic stem (HSC). Ginsenoside Rg1 main active pharmaceutical ingredient of ginseng, which a traditional Chinese medicine. This study explored protective effect ginsenoside on Sca-1⁺ stem/progenitor cells (HSC/HPCs) in mouse model d-galactose-induced aging. The mimetic aging was induced by continuous injection d-gal 42 days, C57BL/6 mice were respectively treated with Rg1,...
Myelosuppression is the most common complication of chemotherapy. Decline self-renewal capacity and stress-induced premature senescence (SIPS) hematopoietic stem cells (HSCs) induced by chemotherapeutic agents may be cause long-term myelosuppression after Whether mechanism SIPS relates to injury occurred in microenvironment (HM) still not well elucidated. This study explored protective effect Angelica sinensis polysaccharide (ASP), an acetone extract found as major effective ingredients a...
Objective . To preliminary explore the senescent dynamic changes of bone marrow mesenchymal stem cells (BMMSCs) by human ageing and its possible mechanism. Methods The marrows were harvested from healthy volunteers, according to volunteers’ age, these divided into group A (≤25 years), B (26-45 C (46-65 D (>65 years). Totally, extracted posterior superior iliac spine volunteers under aseptic conditions. Diluted with isovolumic PBS, followed centrifugation at <mml:math...
The protective effect and mechanism of Ginsenoside Rg1 on aging mouse pancreas damaged by D‑galactose (D‑gal)‑induced was studied. Two-month-old male C57BL/6J mice were randomly divided into three groups 10 per group. D‑gal group received hypodermic injection (120 mg/kg/day) for 42 days; the Rg1+D‑gal receiving + intraperitoneal (40 27 days from 16th day replication; naïve that constituted normal control same dose saline instead drug. related indicators tested second after modeling...
This study investigated the spillover effects of geopolitical risks on energy (crude oil, coal and natural gas) markets. The empirical evidence is based CoVaR index CAViaR-EGARCH model. Results demonstrate that global market are nonlinear, asymmetric time-varying. With each 1% rise in risks, left tail crude coal, gas markets decreased by 0.179%, 0.119% 0.113%, while right increased 0.144%, 0.135% 0.097%, respectively. In addition, magnitude crises triggered different events varies. Lastly,...
Deep reinforcement learning (RL) is an important method to provide solutions for the perception and decision-making problems of complex systems. It has provided great contributions in natural language processing, drug design, gaming, some other fields. This paper gives overview recent achievements deep learning. First, basic concepts regarding learning, are first introduced this paper. Then, milestone related work RL two methods RL: Q-learning-based policy gradient-based reviewed. At last,...
Ginsenoside Rg1 is a major component of ginseng with antioxidative and antiaging effects, which traditional Chinese medicine. In this study, we investigated the potential spillover mechanism action on LiCl-driven hematopoietic stem cell aging.Collect purified Sca-1+ cells for differentiation ability detection biochemical molecular labeling. The experiment found that plays an role in reversing SA-β-gal staining associated LiCl-induced senescence, increase p53 p21 proteins, sustained DNA...
<title>Abstract</title> Cadmium (Cd) is a widely used heavy metal and has recently been recognized as possible source of human toxicity due to its ability accumulate in organs. Accumulation metals several adverse effects, including inducing inflammation, multiple organs, the testis. However, how Cd ions are sensed by host cells tissue inflammation eventually occurs remains unclear. Here, we show that activates AIM2 inflammasome mediating genomic DNA release into cytoplasm after damage via...
Despite the numerous prevention and protection techniques that have been developed, exploitation of memory corruption vulnerabilities still represents a serious threat to security software systems networks. Because adoption write or execute only policy (W⊕X) address space layout randomization (ASLR), modern operate strengthened against code injection attacks. However, attackers responded by employing reuse attacks, in which vulnerability is exploited weave control flow through existing base....
Failure clustering is considered as an effective method to alleviate the burden in software development and maintenance stage. However, since overall fault space extremely large, inherent complexity of "fault-error-failure" chain becomes obstacle failure clustering. In this paper, we present a program behavior characterization which able examine cluster behaviors programs based on their normal executions. We first characterize executions order model runtime behaviors. Then are clustered by...