A5100708968- Cancer-related molecular mechanisms research
- Antioxidants, Aging, Portulaca oleracea
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- MicroRNA in disease regulation
- Neurological Disorders and Treatments
- Hydrogen's biological and therapeutic effects
- Mitochondrial Function and Pathology
- Genetics, Bioinformatics, and Biomedical Research
- Lung Cancer Treatments and Mutations
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Bone Metabolism and Diseases
- Neuroscience and Neural Engineering
- Magnesium Alloys: Properties and Applications
- Caveolin-1 and cellular processes
- Congenital Anomalies and Fetal Surgery
- Dermatological and Skeletal Disorders
- Renal and related cancers
- Advanced Memory and Neural Computing
- GABA and Rice Research
Shanghai Business School
2025
Chongqing Medical University
2015-2024
Dalian Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
United States Food and Drug Administration
2022
// Qingmei Kang 1, 2, * , Yue Xiang Dan Li 2 Jie Liang Xiong Zhang Fanlin Zhou Mengyuan Qiao Yingling Nie Yurong He Jingyi Cheng Yubing Dai 3 Yu 1 Department of Pathology, Chongqing Medical University, Chongqing, 400016, China Center for Molecular Medicine Testing, Neurosurgery, The Affiliated Hospital Guizhou Guiyang, Guizhou, 550004, These authors contributed equally to this work Correspondence to: Li, email: liyu100@163.com Keywords: miR-124-3p, tau, caveolin-1, PI3K/Akt/GSK3β,...
Implantable microelectrodes represent a crucial advancement in Brain-Computer Interfaces (BCIs), enabling wide array of applications across neuroscience and clinical domains. This paper presents comprehensive overview implantable microelectrodes, three kinds microelectrode arrays are explained detail. The also deals with the integration BCI, an emphasis on critical areas such as neuromodulation, including deep brain stimulation neural feedback control, motor recovery, varieties people...
Sterol regulatory element binding protein (SREBP) cleavage-activating (SCAP) is a widely expressed membrane glycoprotein that acts as an important modulator of lipid metabolism and inflammatory stress.
This is a study on the relationship between protective effect of ginsenoside Rg1 senescent neural stem cells and Wnt- β /catenin signaling pathway. Background . Recent studies have shown that overactivation Wnt/ -catenin pathway closely related to cell senescence. Whether delays senescence NSCs regulation this Methods The whole brain Nestin-GFP transgenic newborn rat was extracted, were extracted cultured P3 generation. following indicators detected: (1) NSC culture identification, (2) LiCl...
Objectives . To demonstrate the effect of Ginsenoside Rg1 on differentiation human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Subsequently, a rational mechanism for detection which affects cell was explored. Methods Flow cytometry is used identification. The ability hBM-MSCs studied by culture. SA- β -gal staining to detect senescence levels. Western blot and immunofluorescence were determine protein expression RT-qPCR mRNA Results regulates hBM-MSCs. Differentiation culture...
Abstract Inhibition of cholesterol de novo synthesis (DNS) by statins has controversial effects on the treatment hepatocellular carcinoma (HCC). High fatty acid conditions have been reported to limit effect metabolism diseases. Whether high interfere with HCC remains unclear. Here, we that inhibiting DNS atorvastatin promoted oncogenic capabilities diethylnitrosamine (DEN) in mice fed diets (HFD). The combined analysis metabolomics and transcriptomics revealed arachidonic (AA) was most...
The metanephric mesenchyme (MM) cells are a subset of kidney progenitor and play an essential role in mesenchymal-epithelial transition (MET), the key step nephron generation. Six2, biological marker related to Wnt signaling pathway, promotes proliferation, inhibits apoptosis maintains un-differentiation MM cells. Besides, LiCl is activator pathway. However, cellular regulation remains unclear, relationship between Six2 this process also little known. Here, we performed EdU assay flow...
Background: Colorectal cancer (CRC) is a heterogeneous disease with many somatic mutations defining its genomic instability. Alternative Splicing (AS) events, are essential for maintaining However, the role of instability-related AS events in CRC has not been investigated. Methods: From The Cancer Genome Atlas (TCGA) program, we obtained splicing profiles, single nucleotide polymorphism, transcriptomics, and clinical information CRC. Combining mutation data, signature was constructed...
Background: Immune checkpoint inhibitors combined chemotherapy (ICIC) are widely used for various types of lung cancer in the past decade. However, ICIC related adverse events (AEs) more serious than immune-related (irAE) or cytotoxic alone. Objective: This prospective interventional study aimed to evaluate impact pharmaceutical care program reducing and analyze pharmacy interventions patients with NSCLC who receive therapies. Method: were enrolled this study, was introduced after received...
To observe the effect of curcumin on morphology hippocampus in young and aged rats with vascular dementia (VD) induced by chronic cerebral hypoperfusion, then further investigate whether have any differences age. Both Male Sprague-Dawley were randomly divided into normal control group, sham-operated 2VO 2VO+curcumin 50mg/Kg group 100mg/Kg goup. Permanent occlusion bilateral common carotid arteries ligation (2VO) method was used to establish ischemia model. The injected intraperitoneally or...
Abstract Background : Chemotherapy-induced bone marrow hematopoietic microenvironment oxidative damage is closely related to myelosuppression. Angelica Sinensis Polysaccharides (ASP) are major effective ingredients of traditional Chinese medicine with multi-target anti-oxidative stress features. In this study, we investigated the potential benefits and mechanism action ASP on chemotherapy-induced stromal cell (BMSC) damage. Methods The human line HS-5 cells were divided into control group,...
Abstract Background: Colorectal cancer (CRC) is a heterogeneous disease with multitude of somatic mutations defining its genomic instability. Alternative Splicing (AS) events, the new biomarkers, are essential for maintaining However, role instability-related AS events in CRC has not been investigated. Methods: From The Cancer Genome Atlas (TCGA) program, we obtained splicing profiles, single nucleotide polymorphism (SNP), transcriptomics, and clinical information CRC. Combining mutation...