A5034061216- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
Charles University
2020-2022
Czech Academy of Sciences, Institute of Molecular Genetics
2020
Abstract Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here we show that tetra-transmembrane protein CMTM4 subunit IL-17 receptor (IL-17R). constitutively associated with IL-17R C mediate its stability, glycosylation plasma membrane localization. Both mouse human cell lines deficient in were largely unresponsive IL-17A, due their...
Article21 July 2020Open Access Source DataTransparent process Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop Helena Draberova Laboratory Immunity & Cell Communication, BIOCEV, First Faculty Medicine, Charles University, Vestec, Czech Republic Adaptive Immunity, Institute Molecular Genetics Academy Sciences, Prague, Search for more papers by this author Sarka Janusova Daniela Knizkova Tereza Semberova Michaela Pribikova Andrea Ujevic Karel...