A5004776682- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Drug-Induced Adverse Reactions
- interferon and immune responses
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
Charles University
2022-2024
University of Lausanne
2024
Institute of Virology, Vaccines and Sera “Torlak”
2024
Abstract Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here we show that tetra-transmembrane protein CMTM4 subunit IL-17 receptor (IL-17R). constitutively associated with IL-17R C mediate its stability, glycosylation plasma membrane localization. Both mouse human cell lines deficient in were largely unresponsive IL-17A, due their...
Abstract The cytokine TNF can trigger highly proinflammatory RIPK1-dependent cell death. Here, we show that the two adapter proteins, TANK and AZI2, suppress TNF-induced death by regulating activation of TBK1 kinase. Mice lacking either or AZI2 do not an overt phenotype. Conversely, animals deficient in both adapters are born a sub-Mendelian ratio suffer from severe multi-organ inflammation, excessive antibody production, male sterility, early mortality, which be rescued TNFR1 deficiency...