A5084988813- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- MXene and MAX Phase Materials
- 2D Materials and Applications
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- NF-κB Signaling Pathways
- Advanced Biosensing Techniques and Applications
- Cellular transport and secretion
- interferon and immune responses
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Nuclear Structure and Function
- Advanced Memory and Neural Computing
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Adenosine and Purinergic Signaling
Czech Academy of Sciences, Institute of Molecular Genetics
2018-2024
Charles University
2023
Czech Academy of Sciences
2018-2020
Slovak Academy of Sciences
2016-2017
Abstract The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key fate decisions. Despite decades research, roles CD4–LCK CD8–LCK interactions in TCR triggering vivo remain unknown. In this study, we created animal models expressing endogenous levels modified resolve whether how co-receptor-bound drives signaling. We demonstrated that role depends on co-receptor which it is bound. CD8-bound largely dispensable for...
An impedimetric lectin biosensor for the detection of changes in glycan structure antibodies isolated from human serum is here correlated with progression rheumatoid arthritis (RA). The was built up a mixed self-assembled monolayer (SAM) on gold consisting two different thiolated zwitterionic derivatives, carboxybetaine and sulfobetaine, to resist nonspecific interactions. carboxyl-terminated one applied also covalent immobilization Ricinus communis agglutinin I (RCA-I). process building...
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, relative differences self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but role of biology is incompletely understood. We addressed diversity by generating an atlas mouse peripheral CD8+ cells, which revealed two unconventional populations antigen-inexperienced cells. In next step, we examined...
Abstract T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by T-cell antigen receptors (TCR) co-stimulatory or inhibitory receptors. The molecular regulation of these complex networks is still incompletely understood. Here, we identify adaptor protein ABIN1 as component complexes GITR OX40 co-stimulation lacking...
Abstract The cytokine TNF can trigger highly proinflammatory RIPK1-dependent cell death. Here, we show that the two adapter proteins, TANK and AZI2, suppress TNF-induced death by regulating activation of TBK1 kinase. Mice lacking either or AZI2 do not an overt phenotype. Conversely, animals deficient in both adapters are born a sub-Mendelian ratio suffer from severe multi-organ inflammation, excessive antibody production, male sterility, early mortality, which be rescued TNFR1 deficiency...
Abstract T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by T-cell antigen receptors (TCR) co-stimulatory or inhibitory receptors. The molecular regulation of these complex networks is still incompletely understood. We identified an adaptor protein, ABIN1 as component complexes GITR OX40 co-stimulation lacking...