A5033297723- Tactile and Sensory Interactions
- Pain Mechanisms and Treatments
- Multisensory perception and integration
- Action Observation and Synchronization
- Visual perception and processing mechanisms
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Neurobiology and Insect Physiology Research
- Hereditary Neurological Disorders
- EEG and Brain-Computer Interfaces
- Blind Source Separation Techniques
- Infant Health and Development
- Silicone and Siloxane Chemistry
- Motor Control and Adaptation
- Psychosomatic Disorders and Their Treatments
- Retinal Development and Disorders
- Diverse Scientific and Engineering Research
- Musculoskeletal pain and rehabilitation
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Connexins and lens biology
- Pain Management and Placebo Effect
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
University of Gothenburg
2007-2023
University of California, San Francisco
2016-2021
University of Oxford
2011-2017
Wellcome Centre for Integrative Neuroimaging
2011-2017
John Radcliffe Hospital
2011-2014
Sahlgrenska University Hospital
2006-2009
Somatic sensation comprises four main modalities, each relaying tactile, thermal, painful, or pruritic (itch) information to the central nervous system. These input channels can be further classified as subserving a sensory function of spatial and temporal localization, discrimination, provision essential for controlling guiding exploratory tactile behaviours, an affective that is widely recognized providing afferent neural driving subjective experience pain, but not so also affiliative...
A network of thin (C and Aδ) afferents relays various signals related to the physiological condition body, including sensations gentle touch, pain, temperature changes. Such project insular cortex, where a somatotopic organization responses noxious cooling stimuli was recently observed. To explore possibility corresponding body-map topography in relation touch mediated through C tactile (CT) fibers, we applied soft brush right forearm thigh patient (GL) lacking Aβ afferents, six healthy...
Caregiving touch has been shown to be essential for the growth and development of human infants. However, physiological behavioral mechanisms that underpin infants’ sensitivity pleasant are still poorly understood. In adults, a subclass unmyelinated peripheral nerve fibers respond preferentially medium-velocity soft brushing. It theorized this privileged pathway is used close affiliative interactions with conspecific individuals, especially between caregivers To test whether infants...
We examined patients with a heritable disorder associated mutation affecting the nerve growth factor beta gene. Their condition has been classified as hereditary sensory and autonomic neuropathy type V. Carriers of show reduction in density thin unmyelinated fibres, including C afferents. A distinct unmyelinated, low-threshold mechanoreceptive fibre, C-tactile afferent, is present hairy but not glabrous skin humans other mammals. They have implicated coding pleasant, hedonic touch kind that...
C-tactile (CT) afferents were long-believed to be lacking in humans, but these subsequently shown densely innervate the face and arm skin, a lesser extent leg. Their firing frequency stroking touch at different velocities has been correlated with ratings of tactile pleasantness. CT thought absent human glabrous skin; however, pleasantness can perceived across whole body, including hand skin. We used microneurography investigate mechanoreceptive skin hand, during median radial nerve...
Abstract Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP participants and n 86 healthy controls) facial electromyography 3 8 controls), we found that these patients also have abnormalities encoding affective touch, which mediated by specialized afferents C-low mechanoreceptors (C-LTMRs). In mouse, C-LTMRs...
Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to transmission pain messages. Using tamoxifen-inducible Calca CreER transgenic mouse, here we identified distinct population CGRP-expressing excitatory interneurons in lamina III spinal cord and trigeminal nucleus caudalis. These have spine-laden, dorsally directed, dendrites, ventrally directed axons. As under resting conditions, CGRP tonic...
Hereditary sensory and autonomic neuropathy type III (HSAN III, Riley-Day syndrome, Familial Dysautomia) is characterised by elevated thermal thresholds an indifference to pain. Using microelectrode recordings we recently showed that these patients possess no functional stretch-sensitive mechanoreceptors in their muscles (muscle spindles), a feature may explain lack of stretch reflexes ataxic gait, yet have apparently normal low-threshold cutaneous mechanoreceptors. The density C-fibres the...
Unmyelinated tactile (CT) afferents are abundant in arm hairy skin and thought to signal features of social affective touch. We show that CTs also present but relatively sparse the lower leg compared C nociceptors. display similar physiological properties across nerves. Furthermore, CT do not respond cooling agent menthol or pruritogen histamine, their mechanical response altered by these chemicals.
In the setting of injury, myelinated primary afferent fibers that normally signal light touch are thought to switch modality and instead pain. absence is perceived as more intense when firing rates Aβ afferents increase. However, it not known if varying have any consequence perception dynamic mechanical allodynia (DMA). We hypothesized that, in unpleasantness DMA would be intensified Using a stimulus-response protocol established normal skin, where an increase brush velocity results rates,...
To evaluate the clinical usefulness of quantitative testing tactile direction discrimination (TDD) in patients with diabetic neuropathy.TDD and vibration detection were examined on dorsum feet 43 type 1 diabetes mellitus signs symptoms indicating mild neuropathy, abnormal results for neurography, temperature detection, or heart rate variability. Test-retest examination TDD was performed nine patients.Twenty-six had (sensitivity 0.60) 20 0.46). Ten normal detection. Four TDD. showed a high...
ABSTRACT Numerous microneurography studies in the human peroneal nerve have suggested that CT afferents are lacking more distal parts of limbs. Here we recorded from unmyelinated low-threshold mechanosensitive and radial nerves, with most receptive fields located on proximal phalanx third finger for superficial branch nerve, near lateral malleolus nerve. We found physiological properties regard to conduction velocity mechanical threshold, as well their tuning brush velocity, were similar...
Abstract Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to transmission pain messages. Using tamoxifen-inducible CGRP CreER transgenic mouse, here we identified distinct population CGRP-expressing excitatory interneurons in lamina III spinal cord and trigeminal nucleus caudalis. These have spine-laden, dorsally-directed, dendrites ventrally-directed axons. Neither innocuous nor noxious...