A5085425431- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Pain Mechanisms and Treatments
- Dermatology and Skin Diseases
- Neuroscience and Neuropharmacology Research
- Exercise and Physiological Responses
- Nausea and vomiting management
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Marine Toxins and Detection Methods
- Vitamin D Research Studies
- Psoriasis: Treatment and Pathogenesis
- Drug-Induced Hepatotoxicity and Protection
- Viral-associated cancers and disorders
- Anesthesia and Pain Management
- Transport and Economic Policies
- Poisoning and overdose treatments
- Ion Channels and Receptors
- Parvovirus B19 Infection Studies
- Pain Management and Placebo Effect
- Biochemical and Structural Characterization
- IL-33, ST2, and ILC Pathways
Tehran University of Medical Sciences
2008-2024
University of California, San Francisco
2021-2023
Southeast University
2022
Zhejiang Sci-Tech University
2022
Illawarra Health and Medical Research Institute
2016-2021
University of Wollongong
2016-2021
University of San Francisco
2021
Universidad Católica de Santa Fe
2021
RMIT University
2016-2019
The University of Sydney
2013
Despite robust literature associating IL-31 with pruritic inflammatory skin diseases, its influence on cutaneous inflammation and the interplay between neurosensory pathways remain unmapped. Here, we examined consequences of disrupting
Abstract α‐Conotoxins are disulfide‐rich peptides that target nicotinic acetylcholine receptors. Recently we identified several α‐conotoxins also modulate voltage‐gated calcium channels by acting as G protein‐coupled GABA B receptor (GABA R) agonists. These promising drug leads for the treatment of chronic pain. To elucidate diversity act through this mechanism, synthesized and characterized a set with homology to known inhibit high voltage‐activated via R activation. Remarkably, all...
Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to transmission pain messages. Using tamoxifen-inducible Calca CreER transgenic mouse, here we identified distinct population CGRP-expressing excitatory interneurons in lamina III spinal cord and trigeminal nucleus caudalis. These have spine-laden, dorsally directed, dendrites, ventrally directed axons. As under resting conditions, CGRP tonic...
Loopy peptides: Peptide turn mimetics of a clinically relevant norepinephrine reuptake inhibitor were developed employing high-throughput synthesis approach to generate peptide thioesters, with subsequent cyclization through native chemical ligation. The vicinal disulfide constrained cyclic peptidomimetics (see scheme) show high structural and functional similarity the parent peptide, though superior metabolic stability. As service our authors readers, this journal provides supporting...
α-Conotoxins are disulfide-bonded peptides from cone snail venoms and characterized by their affinity for nicotinic acetylcholine receptors (nAChR). Several α-conotoxins with distinct selectivity nAChR subtypes have been identified as potent analgesics in animal models of chronic pain. However, a number shown to inhibit N-type calcium channel currents rodent dissociated dorsal root ganglion (DRG) neurons via activation G protein-coupled GABAB (GABABR). Therefore, it is unclear whether GABABR...
We here describe a novel α-conopeptide, Eu1.6 from Conus eburneus, which exhibits strong anti-nociceptive activity by an unexpected mechanism of action. Unlike other α-conopeptides that largely target nicotinic acetylcholine receptors (nAChRs), displayed only weak inhibitory at the α3β4 and α7 nAChR subtypes TTX-resistant sodium channels, no TTX-sensitive channels in rat dorsal root ganglion (DRG) neurons, or opiate receptors, VR1, KCNQ1, L- T-type calcium expressed HEK293 cells. However,...
Tapentadol is a novel analgesic that combines moderate μ-opioid receptor agonism and noradrenaline reuptake inhibition in single molecule. Both mechanisms of action are involved producing analgesia; however, the potency efficacy tapentadol individual neurons has not been characterized.Whole-cell patch-clamp recordings G-protein-coupled inwardly rectifying K(+) (KIR 3.x) currents were made from rat locus coeruleus brain slices to investigate relative compare its intrinsic activity with other...
Several Conus-derived venom peptides are promising lead compounds for the management of neuropathic pain, with α-conotoxins being particular interest. Modification interlocked disulfide framework α-conotoxin Vc1.1 has been achieved using on-resin alkyne metathesis. Although introduction a metabolically stable motif significantly disrupts backbone topography, structural modification generates potent and selective GABAB receptor agonist that inhibits Cav2.2 channels exhibits dose-dependent...
Background Antagonists of N-type voltage-gated calcium channels (VGCC), Ca v 2.2, can manage severe chronic pain with intrathecal use and may be effective systemically. A series novel ω-conotoxins that selectively inhibit VGCCs was isolated from Conus catus. In the present study, potency reversibility CVID, CVIE CVIF to currents were investigated in mouse dorsal root ganglion (DRG) neurons. The systemic each ω-conotoxin reverse signs inflammatory also compared. Results DRG neurons, rank...
αO-Conotoxin GeXIVA is a 28 amino acid peptide derived from the venom of marine snail Conus generalis. The presence four cysteine residues in structure allows it to have three different disulfide isomers, that is, globular, ribbon or bead isomer. All isomers are active at α9α10 nicotinic acetylcholine receptors, with isomer, GeXIVA[1,2], being most potent and exhibiting analgesic activity animal models neuropathic pain. original report failed observe any effect on high voltage-activated...
Peptid mit Schleifchen: Peptidschleifen-Mimetika des klinisch relevanten Norepinephrin-Wiederaufnahmehemmers wurden mithilfe einer Hochdurchsatz-Synthese entwickelt, bei der Peptidthioester zunächst erzeugt und anschließend unter nativer chemischer Ligation cyclisiert werden. Die abgebildeten cyclischen Disulfid-Peptidmimetika sind in Struktur Funktion dem Stammpeptid sehr ähnlich, aber deutlich stoffwechselbeständiger. As a service to our authors and readers, this journal provides...
Abstract α‐Conotoxins are disulfide‐rich peptides that target nicotinic acetylcholine receptors. Recently we identified several α‐conotoxins also modulate voltage‐gated calcium channels by acting as G protein‐coupled GABA B receptor (GABA R) agonists. These promising drug leads for the treatment of chronic pain. To elucidate diversity act through this mechanism, synthesized and characterized a set with homology to known inhibit high voltage‐activated via R activation. Remarkably, all...
Introduction: Gastrointestinal cancers are among the most common worldwide. Since some viral infections carcinogenic, they may lead to gastrointestinal tract (GIT) neoplasms. This study aimed at investigating relationship of GIT with John Cunningham Virus (JCV), Herpes Simplex virus (HSV), Epstein-Barr (EBV), Cytomegalovirus (CMV), and Human Papillomavirus (HPV).
<title>Abstract</title> <bold>Background:</bold> The purpose of this study is to examine the frequency intoxication with sedatives-hypnotics, antiepileptics, and anti-Parkinsonism drugs in last four decades (from 1979 2019); considering population growth changes. <bold>Methods:</bold> All poisoned patients admitted Loghman Hakim Hospital Tehran were evaluated. information was classified according ICD-10 coding system. most common reason for poisoning identified period. A new variable defined...
Abstract As the basic unit of railway transportation service, operation enterprises have receive1d more and attention. The improvement efficiency plays a vital role in developing transportation. We used three-stage DEA-Bootstrap model to calculate 38 operators worldwide from 2000 2020. Compared with traditional DEA model, not only eliminates influence environmental variables on value, but also revises random factors efficiency, obtains closest real value. results show that China Railways...
ABSTRACT Despite a robust literature associating IL-31 with pruritic inflammatory skin diseases, its influence on cutaneous inflammation and the interplay between neurosensory pathways remain unmapped. Here, we examined effects of receptor IL31RA both pruritus in mouse models dermatitis, including chronic topical house dust mite (HDM) exposure. Unexpectedly, Il31 deficiency increased adaptive type 2 cytokine-producing cells serum IgE. In addition, M2-like macrophages capable fueling...