A5090339508- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Parasitic infections in humans and animals
- Meningioma and schwannoma management
- Pharmacological Effects and Toxicity Studies
- Intracranial Aneurysms: Treatment and Complications
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Genetic and Kidney Cyst Diseases
- Neonatal and fetal brain pathology
- Head and Neck Surgical Oncology
- Trace Elements in Health
- Vascular Malformations Diagnosis and Treatment
- Nerve injury and regeneration
- Fetal and Pediatric Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Memory and Neural Mechanisms
- Parasite Biology and Host Interactions
- Congenital Anomalies and Fetal Surgery
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
Universidade de São Paulo
2013-2022
Clinics Hospital of Ribeirão Preto
1993-2022
Universidade de Ribeirão Preto
1996-2021
Universidad San Pedro
2007
Universidade Federal de Pernambuco
2002
University of California, Los Angeles
1999
Universidade São Francisco
1990
Fundação Faculdade de Medicina
1986
Sodium-coupled transporters remove extracellular neurotransmitters and alterations in their function could enhance or suppress synaptic transmission seizures. This study determined hippocampal gamma-aminobutyric acid (GABA) glutamate transporter immunoreactivity (IR) temporal lobe epilepsy (TLE) patients.Hippocampal sclerosis (HS) patients (n = 25) non-HS cases (mass lesion cryptogenic; n 20) were compared with nonseizure autopsies 8). Hippocampal sections studied for neuron densities along...
The clinical course of 69 patients with neurocysticercosis who underwent surgery to control increased intracranial pressure (ICP) or cyst removal is analyzed. Increased ICP was caused by hydrocephalus in 63 patients, cerebral edema four, and giant cysts two. Skull x-ray films showed calcifications 14% signs elevated 46%. Examination cerebrospinal fluid (CSF) revealed pleocytosis eosinophils 52% cases a positive complement fixation test for cysticercosis 66%. Ventriculography allowed...
Metabotropic glutamate receptor type 5 (mGluR5) upregulation in temporal lobe epilepsy (TLE) and the correlation of its expression with features hippocampal sclerosis (HS) remains unclear. Here we characterized mGluR5 immunoreactivity hippocampus, entorhinal cortex (EC), subiculum TLE specimens confirmed HS, neocortical (non-HS) necropsy controls. We correlated neuronal density, mossy fiber sprouting, astrogliosis (GFAP), dendritic alterations (MAP2). showed increased expression, which was...
Despite the strong association between epilepsy and psychiatric comorbidities, few biological substrates are currently described. We have previously reported neuropathological alterations in mesial temporal lobe (MTLE) patients with major depression psychosis that suggest a morphological neurochemical basis for psychopathological symptoms. Neuroinflammatory-related structures molecules might be part of altered milieu underlying such features not been investigated humans. MTLE hippocampi...
Temporal lobe epilepsy (TLE) is the most common type of focal and frequently drug-resistant (DR) to antiseizure medication (ASM), corresponding approximately one-third cases. When left inadequately treated, it can worsen quality life, cognitive deficits, risk death. The standard treatment for TLE surgical removal structures involved, with good long-term outcome rates 60-70 % a low rate adverse effects. goal successful sustained seizure freedom. In our study, we evaluated (up 23 years)...
<b><i>Background:</i></b> Several studies suggest that neurocysticercosis is the main cause of symptomatic epilepsy in developing countries. In such areas, calcified cysticercotic lesions (CCL) are frequently found patients with complex partial seizures associated hippocampal sclerosis (HS). The authors studied whether there clinical and pathologic differences between HS without CCL. <b><i>Methods:</i></b> determined findings 30 compared them 32 + Hippocampi from both groups were measured...
Summary: Purpose: We sought to analyze the contralateral volumes of temporal pole, posterior segment lobe, amygdala, hippocampus, and parahippocampal gyrus in patients with lobe epilepsy (TLE) due histologically proven mesial sclerosis (MTLS), seizure free for ≥4 years postsurgical follow‐up. Methods: Forty‐six (23 male) TLE patients, operated on between 1996 2001, histopathologic diagnosis MTLS, a follow‐up years, had their structures manually segmented, measured, compared those 23 normal...
Summary: Purpose: Posterior cortex epilepsies (PCEs) encompass a group of originating from the occipital, parietal, or occipital border temporal lobe, any combination these regions. When their seizures are refractory to pharmacologic treatment, patients usually referred for surgery. The aim our study was analyze clinical characteristics all PCE surgery 1994 2003, and search predictors surgical outcome. Methods: We performed retrospective analysis laboratory data 81 consecutive Surgical...
Changes in the subunit stoichiometry of N-methyl-D-aspartate (NMDA) receptor (NMDAR) alters its channel properties, and may enhance or reduce neuronal excitability temporal lobe epilepsy patients. This study determined whether hippocampal NMDA mRNA levels were increased decreased patients compared with nonseizure autopsy cases. Hippocampal sclerosis (HS; n = 16), non-HS (n 10), hippocampi 9) studied for NMDAR1 (NR1) NR2A–D by using semiquantitative situ hybridization techniques, along neuron...
Cysticercosis is the most frequent parasitosis of central nervous system. Although anticysticercal drugs have proven efficient in some cases, many patients with NCC require palliative, occasionally curative, surgical procedures. The authors analyzed data and prognostic factors obtained during follow-up period (range 1-255 months, median 38 months) 160 cerebral cysticercosis who underwent treatment.Different approaches were indicated to control increased intracranial pressure (ICP) patients,...
Summary Objective Hippocampal sclerosis is a common finding in patients with temporal lobe epilepsy ( TLE ), and magnetic resonance imaging MRI ) studies associate the reduction of hippocampal volume neuron loss seen on histologic evaluation. Astrogliosis increased levels chondroitin sulfate, major component brain extracellular matrix, are also sclerosis. Our aim was to evaluate association between as well neuronal astroglial populations hippocampus . Methods Patients drug‐resistant were...
Despite the strong association between epilepsy and psychiatric comorbidities, data on clinicopathologic correlations are scant. We previously reported differential mossy fiber sprouting (MFS) in mesial temporal lobe (MTLE) patients with psychosis (MTLE + P) major depression D). Because neurotrophins (NTs) can promote MFS, here, we investigated neuronal density immunoreactivity for NT nerve growth factor (NGF), brain-derived neurotrophic (BDNF) neurotrophin 3 (NT3) hippocampi of 14 MTLE...
Summary Objective Biologic substrates behind the close association between mesial temporal lobe epilepsy ( MTLE ) and psychiatric comorbidities are largely unknown. Heat shock protein 70 HSP 70) 90 ubiquitous molecular chaperones that play important roles in functions from cellular stress response to receptor trafficking control. There controversial findings regarding expression epilepsy. Our goal was examine within human hippocampal formation of patients with without comorbid major...
In patients with temporal lobe epilepsy (TLE), presurgical magnetic resonance imaging (MRI) often reveals hippocampal atrophy, while neuropathological assessment indicates the different types of sclerosis (HS). Different HS are not discriminated in MRI so far. We aimed to define volume each subfield on manually and compare automatic manual segmentations for discrimination types. The T2-weighted images from 14 formalin-fixed age-matched control hippocampi were obtained 4.7T evaluate at...
Summary Objective Increased T2 relaxation time is often seen in temporal lobe epilepsy (TLE) with hippocampal sclerosis. Water content directly affects the effective a voxel. Our aim was to evaluate relation between values and two molecules associated brain water homeostasis aquaporin 4 ( AQP 4) chondroitin sulfate proteoglycan CSPG ), as well cellular populations region of patients TLE . Methods Hippocampal imaging diffusion tensor DTI ) were obtained from 42 drug‐resistant 20 healthy...
This study determined if hippocampal AMPA and NMDA subunit immunoreactivity (IR) in temporal lobe epilepsy patients was increased compared with nonseizure autopsies. Hippocampi from sclerosis (HS; n = 26) nonsclerosis cases (non-HS; 12) were autopsies (n 6) studied for GluRl, GluR2/3, NMDAR1, NMDAR2 IR gray values (GV) along fascia dentata Amnion's horn neuron densities. Compared autopsies, non-HS similar densities HS decreased showed: (a) Increased GluRl GVs the molecular layer; (b) NMDAR1...
Summary Purpose: To evaluate the clinical and hippocampal histological features of patients with mesial temporal lobe epilepsy (MTLE) in both familial (FMTLE) sporadic (SMTLE) forms. Methods: Patients FMTLE (n = 20) SMTLE 39) who underwent surgical treatment for refractory seizures were studied at University São Paulo School Medicine Ribeirão Preto. was defined when least two individuals a family had diagnosis MTLE. Hippocampi from all processed Nissl/HE Timm's stainings. Both groups...