Abstract Study Objectives Vascular dysfunction is a hypothesized mechanism linking poor sleep habits to an increased incidence of cardiovascular diseases (CVDs). However, the vascular profile associated with free-living duration and regularity has not been well elucidated, particularly in young adults. Thus, this study aimed evaluate associations between mean duration, peripheral function adult college students. Methods Fifty-one healthy undergraduate students (20 ± 1 years) completed 14...

Short, disturbed, and irregular sleep may contribute to blunted nocturnal blood pressure (BP) dipping, a predictor of cardiovascular disease. Black women (BLW) demonstrate less BP dipping poorer health than White (WHW). However, it remains unclear whether device-estimated metrics mediate the relation between race in young women. We hypothesized that would be partly mediated by duration, efficiency, regularity. Participants (20 BLW, 17 WHW) were 18-29 years old, normotensive, nonobese,...

Emerging adulthood (18-25 years) represents a window of opportunity to modify the trajectory cardiometabolic disease risk into older adulthood. Not known is extent which rest-activity rhythms (RAR) may be related biomarkers health in this population. In cross-sectional, observational study, 52 healthy emerging adults wore wrist accelerometers (14 consecutive days; 24 h/day) for assessment nonparametric RAR metrics, including interdaily stability (IS; day-to-day consistency), intradaily...

This is the first study to compare peripheral microvascular function between young, otherwise healthy Black women and White at multiple phases of menstrual cycle. Our novel findings demonstrate a significant effect race on such that exhibit attenuations in across cycle compared with women.

Sleep irregularity is predictive of poor health outcomes, and particularly those cardiometabolic origins. The immune system implicated in the pathogenesis diseases, however relation between sleep regularity cell profile unclear.Forty-two healthy young adults (20 ​± ​2 years) completed 14 days 24-h wrist actigraphy followed by a morning blood sample to evaluate circulating white cells (WBC) subtypes (neutrophils, lymphocytes, monocytes). was operationalized as standard deviation (SD) nightly...

What is the central question of this study? Is there a racial disparity in macrovascular and/or microvascular function between young black and white women? main finding its importance? Black women (BLW) demonstrated impaired but similar compared to (WHW). These findings suggest an identifiable BLW WHW as early adulthood. Microvascular dysfunction predictive future cardiovascular disease (CVD) generally precedes development dysfunction. Therefore, these also that evaluating CVD risk young,...

Abstract Study Objectives This study aimed to quantify the temporal associations between nightly sleep quantity and timing with daytime eating behavior activity levels in free-living (i.e. non-experimental) settings. Methods Generally healthy young adults (N = 63; 28.9 ± 7.1 years) completed concurrent (wrist actigraphy), (photo-assisted diet records), (waist actigraphy) assessments over 14 days. Multilevel models quantified (total time, of wake onset) next-day (diet quality, caloric intake,...

Background Day-to-day variability in sleep patterns and eating timing may disrupt circadian rhythms has been linked with various adverse cardiometabolic outcomes. However, the extent to which relate atherosclerotic development subclinical stages remains unclear. Methods Results Generally healthy adults (N=62, 29.3±7.3 years, 66% female) completed 14 days of dietary assessments via wrist accelerometry photo-assisted diet records, respectively. Variability duration, onset, onset (time first...

Introduction: Misalignment between lifestyle behaviors and endogenous circadian rhythms is associated with elevated nocturnal blood pressure (BP) in experimental studies; however, less known about free-living (i.e. nonlaboratory) disruption BP. Additionally, sex-specific cardiovascular implications of are unclear. Objective: To examine the associations rest--activity (RAR), a field-based estimate disruption, BP characteristics young men women. Methods: Fifty participants (20 ± 1 years; 20...

Purpose: Child and caregiver sleep occurs in a family system, with socioeconomically disadvantaged families experiencing disproportionately worse health than more advantaged families. The extent to which objectively measured metrics (i.e., duration, midpoint, regularity, efficiency) are concordant within systems, including caregiver-child dyads, is not clear. To address this gap, study aimed to: (1) characterize (2) identify levels of concordance among dyads living socioeconomic disadvantage.

Introduction: Greater regularity in daily sleep and eating timing are independently separately associated with lower carotid intima-media thickness (CIMT), a marker of subclinical atherosclerotic development early adulthood. Not known is the extent to which achieving both would be CIMT as compared either behavior alone, or neither. Such information could help identify behavioral target priorities for cardioprotective interventions. Hypothesis: We tested hypothesis that individuals have than...

Blunted nocturnal blood pressure (BP) dipping, defined as less than 10% reduction in BP during sleep compared to wake, independently predicts cardiovascular disease. Short and disturbed associate with dipping young adults, Black women (BLW) demonstrate poorer health White (WHW) early adulthood. However, not known is if habitual, objectively estimated metrics mediate the relationship between race women. Thus, this study sought evaluate mediating effect of habitual duration effciency on...

Brachial artery (BA) flow-mediated dilation (FMD) is a well-established measure of peripheral vascular function prognostic future cardiovascular events. The vasodilatory response to FMD (FMD%) reflects upper-limb conduit function, whereas reactive hyperemia (RH) following cuff-occlusion release resistance function. Comparatively, passive leg movement (PLM) newer, increasingly utilized assessment lower-limb To increase its clinical utility, PLM-induced blood flow (LBF) responses have been...

Summary Shortened and poor‐quality sleep have emerged as non‐traditional risk factors for the development of hypertension in adults, it is likely these relations extend to paediatric populations when evaluating subjectively. Therefore, we aimed evaluate subjective metrics their associations with central peripheral blood pressure (BP) values children. We hypothesized that short duration would be associated elevated pressures healthy Subjective habits were evaluated using Children's Sleep...

Abstract Introduction Sleep and physical activity behaviors co-exist on a 24-hour continuum of movement, both independently contribute to long-term health. Limited research has examined temporal, day-to-day associations between sleep among caregiver-child dyads dwelling in under-resourced homes. We aim quantify the bidirectional objectively measured health metrics, sedentary behavior (SB), moderate-to-vigorous (MVPA) ecologically valid contexts. Methods 26 families (17 7 triads; N=55) from...

Abstract Introduction Experimental studies show that sleeping and eating at times do not align with one’s endogenous biological timing (‘circadian misalignment’) promotes a physiological environment favors cardiovascular disease (CVD) development. Day-to-day variability in sleep are considered common causes of circadian misalignment the general population. While emerging evidence suggests behaviors predicts overt CVD middle-aged older adults, extent to which these relate biomarkers...

Obtaining sufficient sleep duration in youth may prevent childhood obesity and other poor cardiometabolic outcomes. Sleep irregularity, i.e. variability nightly duration, is a metric of health that has also been associated with increased risk youth. The transition from to adolescence characterized by marked delays wake timing, which directly conflicts societal influences (e.g., early school start times). Thus, adolescents are less likely meet recommendations than children. However, the...

Habitual short sleep duration (<6 hrs/night) has been reliably shown to predict higher blood pressure (BP) and hypertension in adults. However, most studies evaluating this association free-living adults (i.e., non-experimental settings) have: 1. relied on subjective estimates or actigraphy-derived spanning ≤7 days; 2. failed consider central BP, which reported provide greater insight into future cardiovascular risk as compared peripheral BP; 3. neglected the influence of night prior BP...

Introduction: Short sleep duration (&lt;7 h/night) is a risk factor for hypertension and other cardiovascular diseases (CVD). Not clear if delayed timing of or eating behaviors adds to this risk. We tested the hypothesis that later would be associated with higher blood pressure (BP), adults short + late behavior have highest BP vs those one (short OR timing) no (adequate early timing). Methods: Over 14-day period, 30 healthy, non-shift working wore wrist actigraphs evaluate onset timing,...

Abstract Introduction Short sleep predicts the metabolic syndrome (MetS). Extending improves certain MetS factors, specifically insulin sensitivity and blood pressure in adults without MetS. The absence of intervention studies community-dwelling with limits progress advancing extension interventions to this subgroup. This study evaluated feasibility, acceptability, impact on End-of-Treatment (EOT) outcomes a 12-week intervention. Methods Middle aged who were short sleepers at risk for METs...

Abstract Introduction Misalignment between the central circadian clock and daily behaviors increases cardiometabolic morbidity mortality risk, likely due to internal misalignment peripheral rhythms. Experimental studies suggest food intake may act as a time cue (‘zeitgeber’) for resetting rhythms, representing potential behavioral target ameliorate associated health consequences. However, extent which eating timing relates rhythms in free-living adults is unclear. Therefore, we tested...

A race disparity in vascular function has been identified between premenopausal black women and white during the low hormone phase of menstrual cycle. However, to best our knowledge, no previous study assessing macrovascular across cycle reported racial characteristics their participants. PURPOSE: To assess a racially diverse group young, normotensive, non-obese, naturally cycling using brachial artery flow-mediated dilation (FMD). METHODS: Participants self-identified as either non-Hispanic...

Abstract Introduction Child and caregiver sleep typically occurs within a family system. Disadvantaged families experience disproportionately poorer health than more advantaged families. The extent to which objectively measured metrics (e.g. duration, timing, regularity, efficiency) are concordant disadvantaged systems, such as caregiver-child dyads, is not clear. To address this gap, study aimed to: (1) characterize metrics, (2) identify levels of concordance among dyads. Methods 23 dyads...