A5043966171- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Sports Performance and Training
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- High Altitude and Hypoxia
- Exercise and Physiological Responses
- Cardiovascular Effects of Exercise
- Thermoregulation and physiological responses
- Occupational Health and Performance
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Menopause: Health Impacts and Treatments
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Multiple Sclerosis Research Studies
- Cerebral Palsy and Movement Disorders
- Systemic Sclerosis and Related Diseases
- Balance, Gait, and Falls Prevention
- Optical Imaging and Spectroscopy Techniques
- Spinal Cord Injury Research
- Pregnancy-related medical research
University of Maryland, College Park
2018-2025
Mayo Clinic in Arizona
2013-2025
University of Illinois Urbana-Champaign
2009-2022
Mayo Clinic
2013-2019
Northwestern University
2016
Mayo Clinic in Florida
2013-2016
University of Illinois Chicago
2015-2016
WinnMed
2014-2015
University of Iowa
2015
Piedmont International University
2015
Background Multiple sclerosis (MS) is an inflammatory disorder of the brain and spinal cord. Disability status progression are associated with reduced physical activity (PA) cardiovascular function. Lack adequate PA combined inflammation may create high susceptibility to subclinical atherosclerosis vascular dysfunction. Purpose The purpose this study was compare arterial function between individuals without MS matched for age, sex, body mass index. Methods Thirty-three diagnosed 33 controls...
Sudden cardiac events are responsible for 40-50% of line-of-duty firefighter fatalities, yet the exact cause these is unknown. Likely, combinations thermal, physical, and mental factors impair cardiovascular function trigger such events. Therefore, purpose this study was to examine impact firefighting activities on vascular function. Sixty-nine young (28 ± 1 years) male firefighters underwent 3 hours activities. Carotid, aortic, brachial blood pressures (BP), heart rate (HR), augmentation...
Background: The hippocampus is a key brain structure that has been implicated in vascular dementia etiology and highly sensitive to changes cerebral blood flow. Brain hypoperfusion cardiovascular disease may facilitate neurodegeneration the by limiting substrate transport metabolism. While most animal studies have relied on artery occlusion lower flow, can also stem from mechanical damage resulting high flow velocity pulsatility. This study assessed, within same rodent, whether low...
Abstract Peripheral blood mononuclear cells (PBMCs) represent a heterogeneous mix of with paracrine functions that may be altered following prolonged exercise. We determined the effect ultramarathon running on PBMC function and subtype number. Recreational athletes participated in 50 km ultramarathon. Blood was sampled from N = 7 at baseline, 10 km, 24 h post‐race. PBMCs were isolated cultured, conditioned media used for HUVEC‐based proliferation assay. CD31+, CD3+, CD31+/CD3+ quantified...
BACKGROUND: Pharmacological treatments for fibrocalcific aortic valve stenosis (FCAVS) have been elusive >50 years. Here, we tested the hypothesis that reactivation of oxidized sGC (soluble guanylate cyclase), primary receptor nitric oxide, with ataciguat is a safe and efficacious strategy to slow progression FCAVS. METHODS: We used quantitative real-time reverse transcription polymerase chain reaction, Western blotting, immunohistochemistry characterize signaling biological effects on...
The acute effect of high-intensity interval exercise (HI) on blood pressure (BP) is unknown although this type has similar or greater cardiovascular benefits compared to steady-state aerobic (SS). This study examined postexercise hypotension (PEH) and potential mechanisms response in endurance-trained subjects following SS HI. Sex differences were also evaluated. A total 25 men (n = 15) women 10) performed a bout HI cycling randomized order separate days. Before exercise, 30min postexercise,...
This study examined whether a commercially available fish-oil supplement offers protection from the acute effects of high-fat meal (HFM) on endothelial function and arterial stiffness. An HFM causes impairments in function, whereas omega-3 fatty acids eicosapentaenoic acid (EPA) docosahexaenoic (DHA) have variety cardioprotective effects. However, little is known about efficacy moderate supplementation dysfunction induced by an HFM. Endothelial (brachial artery flow-mediated dilation (FMD)),...
We tested the hypothesis that reduced nitric oxide (NO) bioavailability contributes to attenuated peak and total vasodilation following single-muscle contractions in older adults. Young ( n = 10; 24 ± 2 yr) 67 adults performed single forearm at 10, 20, 40% of maximum during saline infusion (control) NO synthase (NOS) inhibition via N G -monomethyl-l-arginine. Brachial artery diameters velocities were measured using Doppler ultrasound vascular conductance (FVC; ml·min −1 ·100 mmHg ) was...
The most effective way of avoiding influenza is through vaccination. However, the vaccine ineffective in about 25% older population. Immunosenescence with advancing age results inadequate protection from disease because responses to Recently, a number strategies have been tested improve efficacy adults. An acute bout moderate aerobic exercise may increase young individuals, but there are limited data adults who would benefit most.This study sought evaluate whether moderate-intensity...
African-American (AA) men have higher arterial stiffness and augmentation index (AIx) than Caucasian-American (CA) men. Women greater age-associated increases in AIx This study examined racial sex differences central hemodynamics at rest after an acute bout of maximal exercise young healthy individuals. One hundred young, individuals (28 AA men, 24 women, 25 CA 23 women) underwent measurements aortic blood pressure (BP) 15 30 min graded aerobic exercise. Aortic BP were derived from radial...
The purpose of this study was to document the physiological changes that occur in a natural bodybuilder during prolonged contest preparation for proqualifying contest. During 26-week preparation, athlete undertook calorically restrictive diet with 2 days elevated carbohydrate intake per week, increased cardiovascular (CV) training, and attempted maintain resistance-training load. weighed twice week body composition measured monthly by DXA. At baseline every weeks following CV structure...
Endothelial function typically exhibits a hormetic response to exercise. It is unknown whether endothelial damage occurs in acute exercise and could be contributing mechanism. We sought determine the effects of on endothelial-derived circulating factors proposed reflect integrity activation. Young, healthy men (n = 10) underwent 30-min moderate continuous (MOD) high-intensity interval (HII) cycling bouts. Venous blood samples were taken immediately before after for quantification cells...
Central arterial stiffness is associated with incident hypertension and negative cardiovascular outcomes. Obese individuals have higher central blood pressure (BP) than their normal-weight counterparts, but it unclear whether obesity also affects hemodynamics after maximal exercise. We evaluated during recovery from acute aerobic exercise in obese individuals. Forty-six twenty-one underwent measurements of BP at rest 15 30 min following normalized augmentation index (AIx@75) were derived...
Blood oxygen saturation (SpO$_2$) is an important indicator for pulmonary and respiratory functionalities. Clinical findings on COVID-19 show that many patients had dangerously low blood levels not long before conditions worsened. It therefore recommended, especially the vulnerable population, to regularly monitor level precaution. Recent works have investigated how ubiquitous smartphone cameras can be used infer SpO$_2$. Most of these are contact-based, requiring users cover a phone's...
Abstract This study was performed to determine whether prolonged endurance running results in acute endothelial dysfunction and wave‐reflection, as arterial stiffness are cardiovascular risk factors. Vascular function (conduit artery/macrovascular resistance artery/microvascular) assessed 11 experienced runners (8 males, 3 females) before, during after a 50 km ultramarathon. Blood pressure (BP), heart rate (HR), wave reflection, augmentation index (AIx) AIx corrected for HR (AIx75) were...
Background. Exercise training intervention is underused in the management of type 2 diabetes mellitus East Africa. Methods. 41 physically-active males with living Mozambique were recruited and randomly assigned to 12 weeks supervised exercise low intensity (LEX), vigorous (VEX), or a control group (CON). Since there no differences for any outcome variables between groups, VEX LEX combined into one (EX). Results. Age baseline body weight similar EX CON. Plasma glucose at 120 min following...
People with Down syndrome (DS) have reduced gait stability and aerobic fitness that increase the metabolic rate during walking, potentially altering relationship between accelerometer output lowering predictability of energy expenditure from accelerometry. Purpose: This study examined whether activity count differs individuals without DS is different groups. Methods: Metabolic was measured in METs portable spirometry 18 subjects (24.7 ± 6.7 yr; 10 women) (26.3 5.2 five overground walking...
We tested the hypothesis that aging would be associated with slowed vasodilator kinetics in contracting muscle part due to a reduced nitric oxide (NO) bioavailability. Young (n = 10; 24 ± 2 yr) and older 67 adults performed rhythmic forearm exercise (4 min each) at 10, 20, 30% of max during saline infusion (control) NO synthase (NOS) inhibition. Brachial artery diameter velocities were measured using Doppler ultrasound. Forearm vascular conductance (FVC) was calculated for each duty cycle (1...
High-intensity interval (HII) exercise elicits distinct vascular responses compared to a matched dose of moderate intensity continuous (MOD) exercise. However, the acute effects HII MOD on arterial stiffness are incompletely understood. Circulating microRNAs (ci-miRs) may contribute We sought determine intensity-dependent changes in ci-miR potentially underlying stiffness. Ten young, healthy men underwent well-matched, 30-min and bouts. RT-qPCR was used levels seven vascular-related ci-miRs...
Endogenous sex hormone concentrations vary between healthy naturally menstruating (non-OCP) and oral contraceptive pill-using (OCP) women, as well across cycles. The aim of this study was to investigate potential differences in inflammatory cytokine interleukin-6 (IL-6) vasoconstrictive substance endothelin-1 (ET-1) measures vascular function among relatively lower- higher-hormone phases non-OCP OCP women. Concentrations estrogen, progesterone, IL-6, ET-1 were collected 22 women (22 ± 1 yr,...
This is the first study to compare peripheral microvascular function between young, otherwise healthy Black women and White at multiple phases of menstrual cycle. Our novel findings demonstrate a significant effect race on such that exhibit attenuations in across cycle compared with women.