A5101849559- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Acute Myocardial Infarction Research
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Venous Thromboembolism Diagnosis and Management
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Ocular Diseases and Behçet’s Syndrome
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Air Quality and Health Impacts
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Renal and Vascular Pathologies
- Pituitary Gland Disorders and Treatments
- Acute Kidney Injury Research
- Breast Implant and Reconstruction
- Children's Physical and Motor Development
- Meningioma and schwannoma management
- Inflammasome and immune disorders
Mayo Clinic
2011-2025
Huazhong University of Science and Technology
2020-2024
Tongji University
2020-2024
WinnMed
2014-2024
Mayo Clinic in Arizona
2017-2023
Tongji Hospital
2020-2023
Ministry of Ecology and Environment
2020
Wuhan University
2019
Renmin Hospital of Wuhan University
2019
McGill University
2019
Bicuspid aortic valve (BAV) is the most common congenital heart anomaly. Lifetime morbidity and whether long-term survival varies according to BAV patient-sub-groups are unknown. This study aimed assess lifetime in patients community.The authors retrospectively identified all Olmsted County (Minnesota) residents with an echocardiographic diagnosis of from 1 January 1980 31 December 2009, including typical valvulo-aortopathy (BAV without accelerated or associated disorders), those complex...
Severe aortic stenosis (AS) is the guideline-based indication for valve replacement (AVR), which has markedly increased with transcatheter approaches, suggesting possible increasing AS incidence. However, reported secular trends of incidence remain contradictory and lack quantitative Doppler echocardiographic ascertainment.
BACKGROUND: Pharmacological treatments for fibrocalcific aortic valve stenosis (FCAVS) have been elusive >50 years. Here, we tested the hypothesis that reactivation of oxidized sGC (soluble guanylate cyclase), primary receptor nitric oxide, with ataciguat is a safe and efficacious strategy to slow progression FCAVS. METHODS: We used quantitative real-time reverse transcription polymerase chain reaction, Western blotting, immunohistochemistry characterize signaling biological effects on...
Purpose.: 1,25-Dihydroxyvitamin D3 (VitD3) has been shown to have immunoregulatory properties in animal models. In this study, we investigated its inhibitory effect on the immune response Behçet's disease (BD) patients and possible mechanisms involved. Methods.: Naive CD4+ T cells from active BD normal controls were cultured under Th17 polarizing conditions presence or absence of VitD3, cytokine production was determined by ELISA flow cytometry. mRNA expression several factors related cell...
Interleukin 27 (IL-27) is an important regulator of the proinflammatory T-cell response. In this study, we investigated its role in pathogenesis Behçet's disease (BD). IL-27 mRNA peripheral blood mononuclear cells (PBMCs) was examined by performing RT-PCRs. Cytokine levels sera or supernatants PBMCs, naïve CD4+ T cells, dendritic (DCs) and DC/T were determined enzyme-linked immunosorbent assay. We used RNA interference to study interferon regulatory factor 8 (IRF8) inhibitory effect on Th17...
Increased arterial stiffness leads to increased pulsatile load on the heart. We investigated associations of components with a measure left ventricular (LV) systolic function—global longitudinal strain (GLS), in community-based cohort ascertained based family history hypertension. Arterial tonometry and echocardiography speckle tracking were performed 520 adults normal LV ejection fraction (EF) (age 67±9 years, 70% hypertensive) quantify measures (characteristic aortic impedance (Zc), total...
Exergames have the potential to significantly increase physical activity in children. Studies date shown mixed results and often rely on self-reported data. Multi-player gaming may augment participation. The purpose of study was examine children's adherence behaviors multi-player online exergames compared a single-player condition within home environment. Seventy-two children, aged 9–12 years, who were not meeting guidelines at baseline, allocated or condition. Six-week cycle-based...
Recent studies show that the aryl hydrocarbon receptor (AhR) is involved in immune responses. AhR activated following interaction with its ligands, such as 6-formylindolo[3,2-b]carbazole (FICZ) and 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE). In this study, we investigated role of activation by endogenous ligands pathogenesis ocular Behcet’s disease (BD). The expression was significantly decreased active BD patients compared to inactive normal controls. Both FICZ...
Abstract Aims Aortic valve calcification (AVC) is prognostic in patients with aortic stenosis (AS). We assessed the AVC value non-severe AS patients. Methods and results conducted a retrospective study of 395 AS, LVEF ≥ 50%. The Agatston method was used for CT assessment. log-rank test determined best cut-offs survival under medical surveillance: 1185 arbitrary unit (AU) men 850 AU women, lower than established severe (2064 1274 women). Patients were divided into 3 groups based on these...
To study anatomical structures related to Meckel cave with endonasal endoscopic approach and provide an basis for surgery in cave.Meckel of 5 adult skulls (10 sides) were fixed 10% formalin. The the zones adjacent observed measured approach.Endoscopic endonasal, endo-maxillary sinus, endo-pterygoid process approaches successfully applied observation meckel rerated measurement distances between each case samples. relevant data obtained. distance front mouth palatovaginal canal vidian was...
Clinical outcomes of bicuspid aortic valve (BAV) patients with ascending diameters ≥50 mm who are under surveillance poorly defined. The purpose this study was to assess clinical in BAV aorta mm. Multicenter retrospective cohort adults by transthoracic echocardiography (TTE). Patients were categorized into 50 54 and ≥55 groups. dissection (AoD), surgery, surgical mortality, all-cause death. Of 875 consecutive (age 60 ± 13 years, 86% men, diameter 51 [interquartile range (IQR): 50-53 mm]),...
Abstract Background Ventricular strain measurements vary depending on cardiac chamber (left ventricle [LV] or right [RV]), type of (longitudinal, circumferential, radial), ventricular level (basal, mid, apical), myocardial layer (endocardial epicardial), and software used for analysis, among other demographic factors such as age gender. Here, we present an analysis taking all these variables into account in a cohort patients with no structural heart disease using vendor-independent...
Objective CT aortic valve calcium score (AVC ) and density thresholds have been recommended for stenosis (AS) severity assessment in tricuspid (TAV). We aimed to compare AVC bicuspid (BAV) versus TAV. Methods Retrospective single-centre study of patients with echocardiographic AS-severity CT-AVC assessments within 6 months, left ventricular ejection fraction ≥50%, all referred clinical AS evaluation. Severe was defined as area (AVA) ≤1 cm 2 or indexed AVA ≤0.6cm /m plus mean gradient ≥40 mm...
A faster expansion rate of abdominal aortic aneurysm (AAA) increases the risk rupture. Women are at higher rupture than men, but mechanisms underlying this increased unknown. We investigated whether genetic variants that influence susceptibility for AAA ( CDKN2A-2B, SORT1, DAB2IP, LRP1 and LDLR) associated with these associations differ by sex in 650 patients (mean age 70±8 years, 17% women) enrolled Mayo Clinic Vascular Disease Biorepository. had a mean 0.41 mm/year greater men after...
Abstract Returning to work can be challenging for burn survivors. Approximately 28% never return any form of employment, resulting in lower health-related quality life. Open communication has been identified as a facilitator (RTW). To ease the RTW process and promote with coworkers employers knowledge translation (KT) intervention was developed Following its implementation, impact on evaluated. This study cross-sectional, mixed methods where survivors included KT were compared control group....
<title>Abstract</title> <bold>Background</bold> An intracoronary wire equipped with a transducer and at least 3 to 4 ml of room-temperature saline injected into the coronary artery during prolonged congestion are often used assess index microcirculatory resistance (IMR). This is time-consuming expensive procedure. <bold>Methods</bold> With invasive wire-based IMR serving as reference standard, this prospective, single-center, randomized study aims evaluate diagnostic performance novel...
Background: Coronary biomechanical stress contributes to the plaque rupture and subsequent events. This study aimed investigate impact of stability on physiological progression intermediate lesions, as assessed by radial wall strain (RWS) derived from coronary angiography. Methods: Patients with at least one medically treated lesion baseline who underwent follow-up angiography over 6 months were included. The maximal RWS (RWSmax) interrogated was calculated angiogram. primary endpoint...
Background: Arterial stiffness is associated with increased risk for adverse cardiovascular outcome. Ankle-brachial index (ABI) a measure reflective of systemic atherosclerosis. Whether it can predict central aortic and its progression unknown. As such, we investigated the impact ABI on carotid-femoral pulse wave velocity (cfPWV) characteristic impedance (Z c ) in apparently healthy adults from community. Methods: Participants were GENOA study without disease at baseline (December 2000 to...