A5074074281- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Microtubule and mitosis dynamics
- Transcranial Magnetic Stimulation Studies
- Axon Guidance and Neuronal Signaling
- Olfactory and Sensory Function Studies
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Redox biology and oxidative stress
- Prion Diseases and Protein Misfolding
- Growth Hormone and Insulin-like Growth Factors
Université de franche-comté
2009-2023
Université de Bourgogne
2016-2022
Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive
2017-2022
Université Bourgogne Franche-Comté
2016-2021
Inserm
2004-2011
Centre Hospitalier Universitaire de Besançon
2011
Biologie de la Reproduction, Environnement, Epigénétique et Développement
2005-2006
Hôpital Saint-Jacques
1999-2004
Centre National de la Recherche Scientifique
1989-2002
University of Southern California
1994-1997
The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly lateral septal part of basal ganglia. Here it is shown that output organized in such way different hippocampal regions map an orderly onto hypothalamic systems mediating expression classes goal-oriented behavior. This mapping characterized by unidirectional hippocampo-lateral then bidirectional septo-hypothalamic projections, all topographically organized....
The organization of axonal projections from the basomedial nucleus amygdala (BMA) was examined with Phaseolus vulgaris leucoagglutinin (PHAL) method in adult male rats. anterior and posterior parts BMA, recognized on cytoarchitectonic grounds, display very different projection patterns. Within amygdala, (BMAa) heavily innervates central, medial, cortical nuclei. In contrast, (BMAp) sends a dense to lateral nucleus, restricted central medial Extra-amygdalar BMA are divided into ascending...
A growing body of evidence suggests that maternal undernutrition sensitizes the offspring to development energy balance metabolic disorders such as type 2 diabetes, dyslipidemia, and obesity. The present study aimed at examining impact on leptin plasma levels in newborn male rats arcuate nucleus proopiomelanocortin (POMC) neuropeptide Y (NPY) neurons are major targets. Using a model perinatal 50% food-restricted diet (FR50) rat, we evaluated hypothalamic POMC NPY gene expression from...
Anterior hypothalamic nucleus (AHN) projections were examined with the Phaseolus vulgaris-leucoagglutinin (PHA-L) method in adult male rats. Labeled axons from AHN follow three major routes. 1) A large ascending pathway ends densely telencephalon, particularly lateral septal nucleus. Axons along this route provide moderate to dense input medial and preoptic areas, a few are also observed septofimbrial fimbria; latter end temporal hippocampus. reach amygdala through bed nuclei of stria...
Epidemiological studies suggest that maternal undernutrition predisposes the offspring to development of energy balance metabolic pathologies in adulthood. Using a model prenatal 70% food-restricted diet (FR30) rats, we evaluated peripheral parameters involved nutritional regulation, as well hypothalamic appetite-regulatory system, nonfasted and 48-h-fasted adult offspring. Despite comparable glycemia both groups, mild glucose intolerance, with defect glucose-induced insulin secretion, was...
Vitamin E supplementation constitutes a promising strategy in the prevention of neurodegenerative diseases. Here, we show that phospholipid transfer protein (PLTP) is widely expressed brain where it appears to function as factor for alpha-tocopherol, main isomer vitamin E. PLTP deficiency results significant depletion alpha-tocopherol both homozygous (-30.1%, P<0.0002) and heterozygous (-18.0%, P<0.05) knocked-out mice. Alpha-tocopherol PLTP-deficient homozygotes associated with elevation...
Significance The network connecting the insular cortex, central nucleus of amygdala, and a caudal hypothalamic nuclear complex including parasubthalamic (PSTN) is interest due to its role in controlling feeding behavior. Here, we show that organization this similar basal ganglia network, implying both fit within simplified structural plan forebrain. Then, demonstrate PSTN modulates behavior response hedonic factors normally inducing “reward effect.” involved “non-feed” equivalent...
The ontogeny of rat diencephalic melanin-concentrating hormone (MCH) neurons has been analysed, using the bromodeoxyuridine method to determine period birth these neurons, and in situ hybridization immunohistochemistry study their chemical differentiation. spatiotemporal pattern MCH neuron generation is complex, although it broadly lateromedial with a peak between embryonic days (E) 12 E13. first expression gene detected on E13 presumptive lateral hypothalamic area. But adult-like was...
Neurons producing melanin-concentrating hormone (MCH) are involved in a large array of functions. Some these functions may be mediated by specific subpopulations. One such subpopulation was characterized the expression neurokinin 3 receptor and 'cocaine- amphetamine-regulated transcript' (CART) peptide, while another expresses neither one two molecules. MCH+/CART+ axons were traced throughout brain showed strikingly different pattern distribution than that MCH+/CART- axons. Particularly,...
Sub-populations of neurons producing melanin-concentrating hormone (MCH) are characterized by distinct projection patterns, birthdates and CART/NK3 expression in rat. Evidence for such sub-populations has not been reported other species. However, given that genetically engineered mouse lines now commonly used as experimental models, a better characterization the anatomy morphofunctionnal organization MCH system this species is then necessary. Combining multiple immunohistochemistry...
To isolate and characterize dental pulp stem cells (DPSCs) obtained from carious healthy mature teeth extracted when conservative treatment was not possible or for orthodontic reasons; to evaluate the ability of DPSCs colonize, proliferate differentiate into functional odontoblast-like cultured onto a polycaprolactone cone made by jet-spraying prototyped design similar gutta-percha cone.DPSCs were nine 12 teeth. Then characterized flow cytometry submitted multidifferentiation confirm their...