A5030779379- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Gestational Diabetes Research and Management
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Pregnancy and preeclampsia studies
- Diabetes Management and Research
- Infant Nutrition and Health
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Apelin-related biomedical research
- Digestive system and related health
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Fatty Acid Research and Health
- Child Nutrition and Feeding Issues
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
Université de Lille
2008-2018
Centre Hospitalier Universitaire de Lille
2018
Université Lille Nord de France
2010-2014
Laboratoire de Neurosciences Intégratives et Adaptatives
2011
Collège de France
2005
Laboratoire de Biologie du Développement
1997-2005
Inserm
1985-2005
Université Paris Cité
1990-1991
Hôpital Bichat-Claude-Bernard
1985-1990
Hôpital Lapeyronie
1990
A growing body of evidence suggests that maternal undernutrition sensitizes the offspring to development energy balance metabolic disorders such as type 2 diabetes, dyslipidemia, and obesity. The present study aimed at examining impact on leptin plasma levels in newborn male rats arcuate nucleus proopiomelanocortin (POMC) neuropeptide Y (NPY) neurons are major targets. Using a model perinatal 50% food-restricted diet (FR50) rat, we evaluated hypothalamic POMC NPY gene expression from...
Human epidemiological studies have shown that low birth weight is associated with hypertension in adulthood. Rodent models of intrauterine growth retardation (IUGR) support these findings because offspring from undernourished dams develop hypertension. Angiotensin-converting enzyme 2 (ACE2) a newly described renin-angiotensin system (RAS) component competes ACE for angiotensin peptide hydrolysis and therefore may modulate blood pressure. However, ACE2 potential participation programming...
Epidemiological studies suggest that maternal undernutrition predisposes the offspring to development of energy balance metabolic pathologies in adulthood. Using a model prenatal 70% food-restricted diet (FR30) rats, we evaluated peripheral parameters involved nutritional regulation, as well hypothalamic appetite-regulatory system, nonfasted and 48-h-fasted adult offspring. Despite comparable glycemia both groups, mild glucose intolerance, with defect glucose-induced insulin secretion, was...
According to the Developmental Origin of Health and Disease (DOHaD) concept, alterations nutrient supply in fetus or neonate result long-term programming individual body weight (BW) setpoint. In particular, maternal obesity, excessive nutrition, accelerated growth neonates have been shown sensitize offspring obesity. The white adipose tissue may represent a prime target metabolic induced by order unravel underlying mechanisms, we developed rat model obesity using high-fat (HF) diet...
Several studies have shown that maternal undernutrition leading to low birth weight predisposes offspring the development of metabolic pathologies such as obesity. Using a model prenatal 70% food restriction diet (FR30) in rat, we evaluated whether postweaning high-fat (HF) would amplify phenotype observed under standard diet. We investigated biological parameters well gene expression profile focusing on white adipose tissues (WAT) adult offspring. FR30 procedure does not worsen syndrome...
According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity accelerated growth in neonates predispose offspring white adipose tissue (WAT) accumulation. In rodents, adipogenesis mainly develops during lactation. The mechanisms underlying phenomenon known as developmental programming remain elusive. We previously reported that adult rat from high-fat diet-fed dams (called HF) exhibited hypertrophic adipocyte, hyperleptinemia increased leptin mRNA levels a...
In humans, an altered control of cortisol secretion was reported in adult men born with a low birth weight making the hypothalamic-pituitary-adrenal (HPA) axis possible primary target early life programming. rats, we have recently shown that maternal food restriction during late pregnancy induces both intrauterine growth retardation and overexposure fetuses to corticosterone, which disturb development HPA offspring. The first aim this work investigate, male whether perinatal malnutrition has...
The adequate control of glucose homeostasis during both gestation and early postnatal life is crucial for the development fetoplacental unit adaptive physiological responses at birth. Growing evidences indicate that apelin its receptor, APJ, which are expressed across a wide range tissues, exert important roles in adults. However, little known about function apelinergic system gestation. In this study, we evaluated activity rats, role fetal neonatal homeostasis, modulation by maternal food...
Remission from insulin dependency in insulin-treated recent-onset type I (insulin-dependent) diabetic patients can result a partial recovery of secretion, an improvement tissue sensitivity to insulin, or both. The same hypothesis must be analyzed when remission occurs cyclosporin A (CsA)-treated patients. In this study, plasma C-peptide levels were serially measured the basal state and after stimulation 219 patients; 129 received CsA, all similarly monitored treated. results view occurrence...
Several studies indicate that maternal undernutrition sensitizes the offspring to development of metabolic disorders, such as obesity. Using a model perinatal 50% food-restricted diet (FR50), we recently reported rat neonates from undernourished mothers exhibit decreased leptin plasma levels associated with alterations hypothalamic proopiomelanocortin system. The present study aimed at examining consequences FR50 on brain-adipose axis in male neonates. quantitative RT-PCR array containing 84...
According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity accelerated growth in neonates program later life. White adipose tissue (WAT) has been focus developmental programming events, although underlying mechanisms remain elusive. In rodents, WAT development primarily occurs during lactation. We previously reported that adult rat offspring from dams fed a high-fat (HF) diet exhibited fat accumulation decreased peroxisome proliferator-activated receptor γ...
The role of glucagon as a mediator aminoacid-induced alteration renal haemodynamics was evaluated in man three different protocols. In the first it shown that increase glomerular nitration rate (GFR) and plasma flow (RPF) observed during an aminoacid infusion prevented by additional somatostatin (SRIF), but reproduced presence SRIF. second protocol that, at variance with normal subjects, six totally pancreatectomised patients, thus deprived pancreatic secretion, did not their GFR RPF when...
Epidemiological studies suggest that maternal undernutrition sensitises to the development of chronic adult diseases, such as type 2 diabetes, hypertension and obesity. Although physiological mechanisms involved in this 'perinatal programming' remain largely unknown, alterations stress neuroendocrine systems hypothalamic-pituitary-adrenal (HPA) sympathoadrenal axes might play a crucial role. Despite recent reports showing perinatal disturbs chromaffin cells organisation activity male rats at...
Epidemiological studies suggest that chronic adult diseases, such as type 2 diabetes and hypertension, can be programmed during fetal early postnatal life. The nervous system regions governing vegetative functions the hypothalamic-pituitary-adrenal axis are particularly sensitive to perinatal nutritional status. Despite recent reports demonstrating activity of sympathoadrenal altered by life events, effects maternal nutrient restriction on adrenal medulla remain unknown. Using a rat model...
Mild gestational hyperglycemia is often associated with fetal overgrowth that can predispose the offspring to metabolic diseases later in life. We hypothesized unfavorable intrauterine environment may compromise development of placenta and contribute overgrowth. Therefore, we developed a rat model investigated effects maternal dysglycemia on growth placental gene expression. Female rats were treated single injection nicotinamide plus streptozotocin (N-STZ) 1-week before mating studied at day...
A close link between intrauterine growth restriction and development of chronic adult diseases such as obesity, diabetes, hypertension has been established both in humans animals. Modification velocity during the early postnatal period (i.e., lactation) may also sensitize to metabolic syndrome adulthood. This suggests that milk composition have long-lasting programming/deprogramming effects offspring. We therefore assess maternal perinatal denutrition on breast a food-restricted 50% (FR50)...
The BB rat develops a spontaneous type I diabetic syndrome with anti-islet autoimmunity. Sera from and nondiabetic rats (from diabetes-prone litters), low-risk lines), nondiabetes-prone Sprague-Dawley were collected twice week age 40 days to 160 days. tested for: (1) complement-dependent toxicity 51Crlabeled islet cells in vitro; (2) immunoglobulin binding RIN-5 F insulinoma cells; (3) ability selectively suppress insulin secretion normal islets vitro. All sera that subsequently became or...