A5041417804- Cancer Immunotherapy and Biomarkers
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric health and respiratory diseases
- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Immunology Research
- Aquaculture disease management and microbiota
- Nanoplatforms for cancer theranostics
- Multiple Myeloma Research and Treatments
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Pharmacological Effects of Natural Compounds
- Escherichia coli research studies
- T-cell and Retrovirus Studies
- Photodynamic Therapy Research Studies
- Yersinia bacterium, plague, ectoparasites research
- Microbial infections and disease research
- Cancer, Hypoxia, and Metabolism
National Institutes of Health Clinical Center
2019-2023
University of Maryland, Baltimore
2015-2019
Consejo Nacional de Investigaciones Científicas y Técnicas
2011-2016
Centro Científico Tecnológico - San Juan
2012
National Agricultural Technology Institute
2012
Hospital César Milstein
2011
Shigella spp. are among the enteric pathogens with highest attributable incidence of moderate‐to‐severe diarrhea in children under 5 years age living endemic areas. There no vaccines available to prevent this disease. In work, we investigated a new vaccine concept consisting nonliving, self‐adjuvanted, Lactococcus lactis bacterium‐like particles (BLP) displaying invasion plasmid antigen (Ipa) B and IpaD examined its immunogenicity protective efficacy adult newborn/infant mice immunized via...
Infection of professional antigen presenting cells by viruses can have a marked effect on these and important consequences for the generation subsequent immune responses. In this study, we demonstrate that different strains bovine viral diarrhea virus (BVDV) infect dendritic differentiated from nonadherent peripheral monocytes (moDCs). BVDV did not cause apoptosis in cells. moDC was prevented incubating with anti-E2 antibodies or pretreating recombinant E2 protein before contact, suggesting...
Yersinia enterocolitica causes a severe enteric infection in infants and young children. There is no vaccine approved for use humans. We investigated the immunogenicity protective capacity of YopB, conserved type III secretion system protein, alone or combined with LcrV adult mice immunized intranasally. YopB (5 μg) administered Escherichia coli double mutant heat-labile toxin (dmLT) adjuvant afforded modest (10-30%) protection against lethal Y. oral infection. The combination μg each)...
143 Background: The aim is to characterize the effect of Radiofrequency Ablation (RFA) with anti-CTLA-4 and anti-PD1 checkpoint inhibitors, on tumor growth immune responses against B16-OVA melanoma tumors implanted in a syngeneic mouse model. Methods: Adult c57BL/6J female mice were distributed among non-tumor placebo group (n=5) four experimental groups: no RFA (n=10); alone (n=5); CPI post-RFA pre-and-post-RFA (n=5). On day 0, inoculated SQ 2.5x10 5 cells. was performed at 15. Three doses...
Objectives: Local and systemic immune responses evoked by locoregional therapies such as cryoablation are incompletely understood. The aim of this study was to characterize cryoablation-related response the capacity drugs augment immunity upon for treatment hepatocellular carcinoma (HCC) using a woodchuck model. Materials Methods: Twelve woodchucks chronically infected with hepatitis virus underwent imaging contrast-enhanced CT. Partial tumors in three performed. Fourteen days after...