Animal, epidemiologic, and human clinical studies suggest a putative role for vitamin D in osteoarthritis (OA). Inadequate sunlight exposure lower serum levels of 25(OH)D appear some reports to be associated with an increased risk progression knee OA.We asked whether treatment would (1) reduce pain (WOMAC VAS), (2) improve function (WOMAC), (3) change relevant biochemical markers patients OA insufficiency.This randomized controlled pilot trial prospectively enrolled 107 insufficiency...

Triage at emergency department is performed to identify those patients who are relatively more serious and require immediate attention treatment. Despite current methods of triage, trauma continues be a leading cause morbidity mortality.This study was evaluate the predictive value shock index (SI) modified (MSI) for hospital mortality among adult patients.In this prospective longitudinal study, all sustained enrolled as per inclusion/exclusion criteria. After collection data, SI MSI were...

Abstract Objective In resource-constrained environments, appropriately employing triage in disaster situations is crucial. Although both case-based learning (CBL) and simulation exercises (SEs) commonly are utilized teaching preparedness to adult learners, there no substantial evidence supporting one as a more efficacious methodology. This randomized controlled trial (RCT) evaluated the effectiveness of CBL versus SEs addition standard didactic instruction knowledge attainment pertaining...

Remodeling, a continuous physiological process maintains the strength of bones, which delicate balance between bone formation and resorption process. This review gives an insight to complex interaction correlation remodeling corresponding changes in host immunological environment also summarises most recent developments occuring understanding this field. T cells, both directly indirectly increase expression receptor activator nuclear factor kB ligand (RANKL); vital step activation...

It is encouraging to see the much needed shift in understanding and recognition of concept burden disease context traumatic injury. Equally important that impact trauma rivals nontraumatic morbidities.Subsequently, this paradigm reinstates appeal for timely interventions as standard management emergencies. Emergency care India has been disorganized due inadequate sensitivity toward patients affected by well haphazard, nonuniform acceptance standardization norm. Some major hospitals across...

Body mass index (BMI) and knee osteoarthritis have a strong association, but other anthropometric measures lack such associations. To date, no study has evaluated non-obese to negate the systemic metabolic effects of obesity. This examines validity contention that BMI significant relationship with osteoarthritis. In total, 180 subjects diagnosis were recruited classified according Kellgren-Lawrence (KL) grades. index, mid-upper arm circumference, waist-hip ratio triceps-skinfold thickness...

Pelvic and acetabular fractures (PAFs) usually result from high-energy, potentially life-threatening accidents. They are one of the major injuries that lead to death in patients involved such We studied recent epidemiology these Singapore.This is a retrospective data analysis all trauma who underwent surgery for PAFs 2008 2016 tertiary centre Singapore. Data including patient demographics, mechanism injury associated was collected.A total 169 were admitted over eight-year period. The...

The present study investigated to identify the association of polymorphism in GDF-5 gene with osteoarthritis North Indian population. In a case-control study, 300 cases knee and an equal number age gender matched healthy controls were included. Cases diagnosed using ACR Guidelines Knee Osteoarthritis (KOA). Clinical symptoms assessed specific WOMAC index VAS for pain. severity disease was determined by radiological KL grades (Kellgren Lawren). variant genotype found be at significantly...

Background: Road traffic injury (RTI) is emerging as a huge public health problem throughout the world. The magnified manifold it mainly affects people in productive age-group causing significant mortality and disability. Very few studies have been done India to assess disability following RTI though has attained astronomic proportions. This study was undertaken know proportion of an outcome amongst patients admitted for road injuries tertiary care centre Lucknow, determinants Traffic...

Aims: The aim of this study is to analyze the serial estimation phosphorylated neurofilament heavy (pNF-H) in blood plasma that would act as a potential biomarker for early prediction neurological severity acute spinal cord injuries (SCI) adults.Settings and Design: Pilot study/observational study.Subjects Methods: A total 40 patients (28 cases 12 controls) spine injury were included study. In enrolled cases, level pNF-H was evaluated samples evaluation performed by American Spinal Injury...

Objectives: There are several approaches for rehabilitation of stroke patients.Proprioceptive Neuromuscular Facilitation (PNF) and Task Specific Training the two approaches, known to promote motor learning control.In this study we aim compare both on basis Brain Derived Neurotrophic Factor (BDNF) levels in serum before after intervention at 6 months.Methods: 90 subjects were recruited study.Subjects divided into groups.Group 1 was given PNF exercises group 2 task specific training.Both...

Background . Hip distraction in Perthes’ disease unloads the joint, which negates harmful effect of stresses on articular surfaces, may promote sound healing area necrosis. We have examined arthrodiastasis preservation femoral head older children with disease. Methods and Materials Twelve age more than 8 years less one year were treated hip by a hinged monolateral external fixator. Observation Results Mean duration was 13.9 days. These evaluated clinicoradiological parameters for mean period...

th weeks, from the initial day of scoring, without revealing patients identity or fracture duration. Finally to check reliability RUST score, Intraclass correlation coefficient (ICC) with 95% confidence intervals (CI) was measured. Results: Overall agreement statistically significant. The test-retest significant, having value 0.87, 0.95, 0.94, 0.98 and 0.97 respectively at each follow-up. overall inter as well intra-observer score collectively significant Conclusions: shows substantial...

Dengue is a mosquito-borne disease caused by arbovirus and well known for its typical fever with thrombocytopenia syndrome. Acute hypokalemic quadriparesis rare presentation of dengue uncertain pathogenesis. We aim to describe the clinical biochemical characteristics rapidly resolving weakness related hypokalemia in patients infected virus.A retrospective review records diagnosis dengue-associated was performed. Demography, clinical, characteristics, outcome were recorded during acute phase...

The role of genetic factors influencing osteoarthritis (OA) susceptibility is well documented and several candidate genes have been identified to be associated with it. Among these are Bone Morphogenetic Protein 5 (BMP5) Smad family member 3 (SMAD3), all involved in Transforming Growth Factor (TGF) signaling pathway. knee the commonly affected joint, OA has an especially high prevalence Asian population.To investigate associations between Single Nucleotide Polymorphisms (SNPs) rs12901499...

Helmet, as a protective gear to prevent fatal injuries while riding two-wheelers, needs be evaluated by quality data. The aim of the study was find out spectrum sustained with downstream outcomes in relation acceptable ways use crash-proof helmet among motorized two-wheeler riders compared nonuse following road traffic accidents. present an analytical cross-sectional multicentric conducted at three dedicated trauma care centers India: (a) Jai Prakash Narayan Apex Trauma Center, All India...

Background. This study was conducted with the aim of evaluating role Ligamentotaxis in management neglected clubfeet managed by ligamentotaxis using Joshi's External Stabilisation System (JESS). Method & Material. Total 20 subjects (28 feet) were studied, which corrected differential JESS. All evaluated clinically, radiologically, podogrammically, and Catterall Pirani Scoring System, both before after correction. Results. Severity deformities clinical correction assessed score. patients...

Swyer-James-MacLeod syndrome is characterised by unilateral hyperlucency on chest radiograph with small or normal-sized lung the affected side and compensatory hyperinflation of opposite lung. Hyperinflation a very rarely reported entity. An adult female patient, who presented exertional breathlessness diagnosed to have hypoplastic left pulmonary artery hyperlucent, hyperinflated herniated described.

Background . Many factors are responsible for this impaired healing, especially in long bones, but a possible genetic predisposition the development of complication remains unknown till now. In present study, we aim to examine CYR61 gene polymorphism fracture nonunion patients and correlation with clinical findings. Materials Methods We performed SNP analysis 250 healthy subjects were genotyped hospital-based case control 56 cases further evaluated mRNA expression by real-time quantitative...

Rural transport and accessibility problems cause isolation, which is one of interlocking dimensions poverty. Improving rural access to facilities, services employment opportunities are now emphasized as an effective means towards poverty alleviation. Travel the by people gain facilities they need for everyday life. Distance, time, effort cost measures level if too high constrain potential development. The settlements devoid all weather road connectivity have poor thus immobility their...