A5051503577- Glioma Diagnosis and Treatment
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Pesticide Exposure and Toxicity
- Epigenetics and DNA Methylation
- Brain Tumor Detection and Classification
- Circular RNAs in diseases
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Neurogenetic and Muscular Disorders Research
- Inflammatory Biomarkers in Disease Prognosis
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Meningioma and schwannoma management
- Extracellular vesicles in disease
- Public Health and Nutrition
- Brain Metastases and Treatment
- Computational Drug Discovery Methods
- Pluripotent Stem Cells Research
- Edcuational Technology Systems
- Neuroblastoma Research and Treatments
- Spinal Cord Injury Research
Universitas Gadjah Mada
2016-2025
Rumah Sakit Umum Pusat Dr. Sardjito
2017-2025
ADA University
2023
Kobe Gakuin University
2013-2015
Kobe University
2010-2012
Abstract Background Gliomas present a significant economic burden and patient management challenge. The 2021 WHO classification incorporates molecular parameters, which guide treatment decisions. However, acquiring these data involves invasive biopsies, prompting need for non-invasive diagnostic methods. This study aims to assess the potential of Visually AcceSAble Rembrandt Images (VASARI) MRI features predict glioma characteristics such as grade, IDH mutation, MGMT methylation status....
Stroke remains one of the most common noncommunicable diseases among Indonesian populations. This study aimed to identify prevalence stroke and its associated risk factors in Sleman District Yogyakarta Special Region, Indonesia. was a secondary analysis community-based data collected by Health Demographic Surveillance System (HDSS) 2016. Basic demographic socioeconomic were collected. Additional questions about history other chronic interviewed as self-reported diagnosis. History hormonal...
This study aimed to determine the effectiveness of gotu kola ( Centella asiatica ) in improving cognitive function patients with vascular impairment (VCI). uses a quasi‐experimental design. Subjects this were poststroke who treated at two hospitals Yogyakarta, Indonesia. The number subjects was 48: 17 1000 mg/day extract, 750 and 14 3 folic acid for 6 weeks. A Montreal Cognitive Assessment‐Indonesian version (MoCA‐Ina) conducted beginning treatment after weeks therapy. It found that all...
Background: Gliomas are the most frequent primary brain tumors. According to World Health Organization guidelines, gliomas graded into four groups (Group I-IV). This histological grading will determine prognosis and treatment of patient. Morphological criteria not always accurate. Tumor proliferation index is a potent quantitative marker for tumor behavior prognosis, also it's basis gliomagenesis. Ki-67 immunohistochemistry examination determining has been suggested as an ancillary in...
Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells (MSCs) have the potential alleviate inflammation and reduce mortality length of stay patients. We investigated safety effectiveness normoxic-allogenic umbilical cord (NA-UC)-MSCs as an adjunctive treatment severe A double-blind, multicentric, randomized, placebo-controlled trial involving patients was performed from January June 2021 three major hospitals across Java, Indonesia. Eligible...
The extensive use of pesticides may cause acute and chronic intoxication. Therefore, this study aimed to reveal the associations between pesticide exposure serum markers for stroke risk factors in farmers. A cross-sectional was conducted with farmers, who used chemical Seloprojo Village, Ngablak District, Magelang Regency, Central Java Province, Indonesia. questionnaire containing demographics, use, aspects related work employed. Measurements cholesterol, uric acid, glucose, cholinesterase,...
Duchenne/Becker muscular dystrophy (DMD/BMD) is the most common genetic neuromuscular disease in children, resulting from a defect DMD gene located on Xp21.2. The new emerging treatment using exon skipping strategy tailored to specific mutations, thus molecular diagnostics are particularly important. This study aimed detect deletion Indonesian DMD/BMD patients and analyze potential amenability by therapy. Thirty-four male were enrolled this study, 23 of them (67.6%) underwent muscle biopsy...
Background: The O6-methylguanine-DNA methyltransferase (MGMT) gene prevents mismatch in DNA replication and transcription by repairing mutagenic lesions. MGMT is a predictor biomarker of chemotherapy high-grade low-grade gliomas based on high-risk clinical conditions. It also can be used for therapeutic decisions to predict hypermutation recurrence newly diagnosed gliomas. gold standard examination the methylation Polymerase Chain Reaction (PCR). However, this technique not widely available...
This study was done to understand the prevalence of various occupational diseases including dry eyes, nail dystrophy, and neuropathy related pesticide exposure in Indonesian local vegetable farmers.The data were collected through questionnaires physical examination involving dermatology, neurology, ophthalmology domains at Ngablak District, Magelang, Central Java directed farmers. Ocular Surface Disease Index (OSDI) questionnaire Schirmer test used. Analysis using descriptive statistics...
Insertion/deletion polymorphism in ACE gene (ACE I/D) is known to be associated with the occurrence of ischaemic stroke through its effect on pathogenesis atherosclerosis and hypertension. This study was aimed examine association between this functional outcome stroke.This a cross-sectional study. The subjects were patients reference hospital Yogyakarta, Indonesia. Data demographic characteristics, risk factors, comorbidities severity assessed admission. outcome, Barthel index (BI), when...
Background: Gliomas remain one of the most common primary brain tumors. Mutations in isocitrate dehydrogenase (IDH) gene are associated with a distinct set clinicopathological profiles. However, distribution and significance these mutations have never been studied Indonesian population. This study aimed to elucidate association between IDH as well prognostic profiles patients gliomas. Methods: In total, 106 gliomas were recruited from tertiary academic medical center Yogyakarta, Indonesia....
Abstract Background Duchenne muscular dystrophy, a fatal muscle-wasting disease, is characterized by dystrophin deficiency caused mutations in the gene. Skipping of target exon during splicing with antisense oligonucleotides attracting much attention as most plausible way to express DMD. Antisense have been designed against regulatory sequences such enhancer exons. Recently, we reported that chemical kinase inhibitor specifically enhances skipping mutated 31, indicating existence...
Objectives: This study aimed to leverage Visually AcceSAble Rembrandt Images (VASARI) radiological features, extracted from magnetic resonance imaging (MRI) scans, and machine-learning techniques predict glioma grade, isocitrate dehydrogenase (IDH) mutation status, O6-methylguanine-DNA methyltransferase (MGMT) methylation. Methodology: A retrospective evaluation was undertaken, analyzing MRI molecular data 107 patients treated at a tertiary hospital. Patients underwent scans using...
BACKGROUND: Hyperglycemia is common in acute stroke patients. can induce the production of reactive oxygen species, causing increased activity matrix metalloproteinase-9 (MMP-9).
 AIM: This study aimed to determine an association between levels MMP-9 and incidence hyperglycemia ischemic patients.
 METHODS: a case-control study. Acute patients admitted Stroke Unit reference hospital Yogyakarta, Indonesia was divided into hyperglycemic non-hyperglycemic group. Demographic clinical...
Abstract Metastatic breast cancer may present as a pericardial effusion that can progress to life‐threatening cardiac tamponade. Pericardial window followed by initial chemotherapy needs be immediately applied in order achieve favorable outcome.
Background: IDH1 mutation shows diagnostic, prognostic, and predictive value in gliomas. Direct Sanger sequencing is considered the gold standard to detect mutation. However, this technology not available most neuropathological centers developing countries such as Indonesia. Immunohistochemistry (IHC) polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) have also been used This study aimed compare DNA sequencing, IHC, PCR–RFLP detecting mutations Methods: Research...
Objective: Seizure is commonly found in patients with glioma. This study aimed to find risk factors for seizures Indonesian We also sought determine the association between seizure and survival this patient population. Methods: Patients glioma were enrolled from Dr. Sardjito General Hospital other hospitals Yogyakarta Province, Indonesia. Detailed demographic clinical data collected medical records. DNA extraction polymerase chain reaction (PCR) performed detect IDH1 mutation. Tumor tissue...
<ns3:p>Background Duchenne muscular dystrophy (DMD) and Becker (BMD) are allelic disorders caused by mutations in the <ns3:italic>DMD</ns3:italic> gene. The full mutation spectrum of gene Indonesian patients is currently unknown. Mutation-specific therapies being developed, such as exon skipping or stop codon read-through therapy. This study was conducted with aim identifying Indonesia to guide future development application feasible therapeutic strategies. Methods a cross sectional that...
Antisense oligonucleotides (AOs) can facilitate the expression of internally deleted dystrophin in dystrophin-deficient Duchenne muscular dystrophy (DMD) by correcting reading frame pre-mRNA with AO-mediated exon skipping. An antisense 18-mer 2′-O-methyl RNA/ethylene-bridged nucleic acid chimera AO targeting 45 gene, AO85, induce skipping efficiently cultured cells. AO85 is expected to 8%–9% all DMD patients. Here, we examined kinetics AO85-mediated a cell-free splicing system. In vitro...
Background: Meningioma is the most common primary intracranial tumor. Previous studies have shown possible association between hormonal contraceptive use and meningioma location. Therefore, this study aimed to analyze history of location in Indonesian population. Methods: In total, 99 histologically confirmed female patients admitted Dr. Sardjito General Hospital Yogyakarta, Indonesia, were included study. Data on contraception other variables collected from medical records. locations...