A5012383476- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Public Health and Nutrition
- Lung Cancer Treatments and Mutations
- Antibiotics Pharmacokinetics and Efficacy
- Lung Cancer Diagnosis and Treatment
- Mesenchymal stem cell research
- COVID-19 and healthcare impacts
- Leprosy Research and Treatment
- Drug-Induced Ocular Toxicity
- Pharmacological Receptor Mechanisms and Effects
- Cardiac electrophysiology and arrhythmias
- COVID-19 Impact on Reproduction
- Occupational and environmental lung diseases
- Infectious Diseases and Tuberculosis
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Tuberculosis Research and Epidemiology
- Legal and Policy Analysis in Indonesia
- Advanced biosensing and bioanalysis techniques
- Air Quality and Health Impacts
- Pleural and Pulmonary Diseases
Rumah Sakit Umum Pusat Dr. Sardjito
2024
Universitas Gadjah Mada
2015-2023
Ito Hospital
2021
Background: Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) Delta variant (B.1.617.2) has been responsible for the current increase in disease 2019 (COVID-19) infectivity rate worldwide. We compared impact of and non-Delta on COVID-19 outcomes patients from Yogyakarta Central Java provinces, Indonesia. Methods: In this cross-sectional study, we ascertained 161 patients, 69 with 92 variant. The Illumina MiSeq next-generation sequencer was used to perform whole-genome sequences...
Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells (MSCs) have the potential alleviate inflammation and reduce mortality length of stay patients. We investigated safety effectiveness normoxic-allogenic umbilical cord (NA-UC)-MSCs as an adjunctive treatment severe A double-blind, multicentric, randomized, placebo-controlled trial involving patients was performed from January June 2021 three major hospitals across Java, Indonesia. Eligible...
Abstract Background Transmission within families and multiple spike protein mutations have been associated with the rapid transmission of SARS-CoV-2. We aimed to: (1) describe full genome characterization SARS-CoV-2 correlate sequences epidemiological data family clusters, (2) conduct phylogenetic analysis all samples from Yogyakarta Central Java, Indonesia other countries. Methods The study involved 17 patients COVID-19, including two clusters. determined full-genome using Illumina MiSeq...
Abstract The outcome of SARS-CoV-2 infection is determined by multiple factors, including the viral, host genetics, age, and comorbidities. This study investigated association between prognostic factors disease outcomes patients infected with S protein mutations. Fifty-one COVID-19 were recruited in this study. Whole-genome sequencing 170 full-genomes was conducted Illumina MiSeq sequencer. Most (47%) had mild symptoms followed moderate (19.6%), no (13.7%), severe (4%), critical (2%)....
Prolonged nucleic acid conversion and false-negative real-time polymerase chain reaction (RT-PCR) results might occur in COVID-19 patients rather than infection recurrence.We reported four cases who had negative RT-PCR results, addition to the last two consecutive results. Patient-1 twice (the 6th 8th) from a total of 11 swabs. Patient-2 once 5th) 8 Patient-3 showed 4th 6th) Patient-4 2nd 10th) 14 swabs.The fluctuating trend our be due insufficient viral material specimen, laboratory errors...
Abstract Background The SARS-CoV-2 Omicron variant has replaced the previously dominant Delta because of high transmissibility. It is responsible for current increase in COVID-19 infectivity rate worldwide. However, studies on impact severity are still limited developing countries. Here, we compared outcomes patients infected with and variants associated prognostic factors, including age, sex, comorbidities, smoking. Methods We involved 352 patients, 139 213 variant. whole-genome sequences...
Background. Under the National Comprehensive Cancer Network (NCCN) guidelines for non-small-cell lung carcinoma (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangement is required to be assessed. However, data showing prevalence of ALK still deficient and not yet available in Indonesia. This study used direct smear preparation from transthoracic needle specimens that are minimally invasive. The main objective identify fusion cytological specimens. Materials Methods. A total 35...
Abstract Background The SARS-CoV-2 Omicron variant has replaced the previously dominant Delta because of high transmissibility. However, studies on impact severity COVID-19 are still limited in developing countries. Our study aimed to determine prognostic factors for outcomes patients infected with and variants, including age, sex, comorbidities, smoking. Methods In this retrospective cross-sectional study, we involved 352 from Yogyakarta Central Java provinces, Indonesia, May 2021 February...
Abstract Background Hydroxychloroquine/chloroquine (HCQ/CQ) treatment for COVID‐19 was associated with QT interval prolongation and arrhythmia risks. This study aimed to investigate QTc ventricular repolarization dispersion changes, as markers of risks, after HCQ/CQ administration with/without azithromycin (AZT) during pandemic. Methods A prospective observational performed in two academic hospitals Indonesia. Adult patients who received alone + AZT concomitant treatments infection were...
Studies to confirm the efficacy and safety of convalescent plasma (CP) as an adjunctive treatment for COVID-19 are still required especially countries where standard treatments unevenly distributed. A non-randomized comparative study was done from June – September 2020 in Dr. Sardjito Hospital, Yogyakarta, Indonesia. Plasma with anti-SARS-CoV-2 specific IgG titer >1:320 were used. Primary end points clinical laboratory parameters outcome including BGA, chest X-ray, CT value, CRP,...
Introduction: Tuberculosis (TB) remains a leading problem in developing and endemic countries. Cerebral tuberculosis is rare but dangerous complication of infection the central nervous system. The immunosuppressive condition human immunodeficiency virus risk factor for severe tuberculosis. Case Report: An Indonesian man, 32 years old, married, came with complaints headaches, dizziness, delirium, nausea vomiting since 1 month before examination. He had history TB treatment year results...
Coronavirus 2019 (COVID-19) is an infectious disease that becoming a pandemic. Hydroxychloroquine in combination with azythromycin are among drugs currently use to eradicate COVID-19. Despite concerns due its potential cardiac toxicity, hydroxychloroquine widely accepted mild and moderate COVID-19 pneumonia. In this case report, we report of young Indonesian adult male suspected pneumonia who received therapies during 24 hour experienced deterioration atrioventricular block.
The rapid spread of the coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality globally. Hydroxychloroquine is one medications for eradicating COVID-19. Despite concerns due to its potential cardiac toxicity, hydroxychloroquine widely used treating mild moderate COVID-19 pneumonia. In this case report, we report two cases Indonesian adult patients with suspected pneumonia who received as part experienced deterioration conduction which required stopping drug...
Background: The SARS-CoV-2 infection or COVID-19 disease caused significant morbidity and mortality. Early reports showed clinical improvement with hydroxychloroquine (HCQ) chloroquine (CQ). However, due to the concern of QTc interval prolongation, strict electrocardiogram monitoring was needed. use risk stratification score may help decision this monitoring.
 Aims: study purpose is describe Tisdale in patients who received HCQ/CQ treatment.
 Methods: This a prospective...
Abstract Background SARS-CoV-2 Delta variant (B.1.617.2) has been responsible for the current increase in COVID-19 infectivity rate worldwide. We compared impact of and non-Delta on outcomes patients from Yogyakarta Central Java provinces, Indonesia. Methods ascertained 161 patients, 69 with 92 variant. The Illumina MiSeq next-generation sequencer was used to perform whole genome sequences SARS-CoV-2. Results mean age 27.3 ± 20.0 43.0 20.9 ( p =3×10 −6 ). consisted 23 males 46 females, while...
Pulmonary hypertension (PH)-associated with interstitial lung disease (ILD) develops as a consequence of progressive underlying or disproportionately to the disease. The PH investigation by right heart catheterization (RHC) for defining severity is recommended in patients ILD who show more severe symptoms than expected from disease, appearance failure, and clinical deterioration not matched declining function. In patient ILD, RHC only considered if it affects future treatment such...
Long COVID syndrome refers to a condition in which individuals experience range of persistent symptoms and health issues following the acute phase COVID-19 infection. A 26-years-old Indonesian lady presented ER department with complaining shortness breath since 10 days before admission. Patient had history Covid-19 one year ago, then she always breath. Research Objectives identify that persist long COVID, characterize severity variability these among affected individuals, Evaluate Duration...
COVID-19 is a respiratory disease caused by SARS-CoV-2, corona virus that was discovered at the end of 2019. Diabetes mellitus (DM) second highest comorbidities in Indonesia patients. One treatments for patients corticosteroids. Commonly used corticosteroids are dexamethasone, methylprednisolone, and hydrocortisone. This study aims to determine effect corticosteroid therapy with DM so it can be source information reference management research narrative review using literature from science...
Latar Belakang : Kota Bengkulu merupakan daerah rawan terhadap bencana karena terletak pada pertemuan lempeng tektonik Samudera Hindia dan Asia yang menyebabkan gempa bumi tsunami. Rumah sakit dapat menjadi tidak berfungsi disaat keadaan darurat apabila terjadi kegagalan struktural ataupun ketidaksiapan tim pelayanan kesehatan dalam menyelamatkan nyawa orang korban saat terjadi. Komitmen manajemen rumah suatu hal sangat penting keberhasilan melaksanakan kegiatan kesiapsiagaan menghadapi di...
Abstract Background: Prolonged nucleic acid conversion and false-negative results of real-time reverse transcription polymerase chain reaction (RT-PCR) might occur in some patients with COVID-19 rather than recurrence infection. Here, we reported four cases prolonged RT-PCR our institution. Case presentation: 1: A 36-year-old-male patient complained coughing up phlegm one week before admission. His chest X-rays showed mild pneumonia the right lung. swab test was confirmed positive for...
Abstract Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells (MSCs) have the potential alleviate inflammation and reduce mortality length of stay patients. We investigated safety effectiveness normoxic-allogenic umbilical cord (NA-UC)-MSCs as an adjunctive treatment severe A double-blind, multicentric, randomized, placebo-controlled trial involving patients was performed from January–June 2021 three major hospitals across Java, Indonesia....
Abstract Background: Recent studies focusing on the association of SARS-CoV-2 variants concern (VOC) COVID-19 outcomes have been reported. However, impact multiple mutations within spike (S) protein illness are limited. This study determined between S protein, prognosis factors, and disease infection. Methods: We included 51 patients from Yogyakarta Central Java, Indonesia. Whole genome sequences were by Illumina MiSeq next-generation sequencer, followed phylogenetic analysis 170...