A5002159050- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- vaccines and immunoinformatics approaches
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Proteoglycans and glycosaminoglycans research
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Neurological Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Endometrial and Cervical Cancer Treatments
- HER2/EGFR in Cancer Research
- Parathyroid Disorders and Treatments
- Acute Kidney Injury Research
- Viral Infections and Vectors
- Nitric Oxide and Endothelin Effects
- Ovarian cancer diagnosis and treatment
- Renal and Vascular Pathologies
- Data-Driven Disease Surveillance
Universitas Gadjah Mada
2013-2024
Rumah Sakit Umum Pusat Dr. Sardjito
2024
Duta Wacana Christian University
2024
Ito Hospital
2021
ADA University
2013-2021
Kobe University
2011-2013
National Center for Infectious Diseases
2013
Abstract Hemodialysis patients are at an increased risk of acquiring hepatitis B virus (HBV) and C (HCV) infection. However, the prevalence viral infection its genotype distribution among hemodialysis in Indonesia unclear. In order to investigate these issues possibility nosocomial transmission, 161 35 staff members one unit Yogyakarta, Indonesia, were tested for serological virological markers both viruses. HBV surface antigen (HBsAg) was detected 18 (11.2%) two (5.7%). Anti‐HCV 130 (80.7%)...
Background: Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) Delta variant (B.1.617.2) has been responsible for the current increase in disease 2019 (COVID-19) infectivity rate worldwide. We compared impact of and non-Delta on COVID-19 outcomes patients from Yogyakarta Central Java provinces, Indonesia. Methods: In this cross-sectional study, we ascertained 161 patients, 69 with 92 variant. The Illumina MiSeq next-generation sequencer was used to perform whole-genome sequences...
Objectives Colon and rectal cancer are associated with different risk factors prognostic. However, this discrepancy has not been widely explored in the local population. This study aimed to investigate site-specific likelihood of colorectal (CRC) incidence Yogyakarta province, Indonesia. Methods cross-sectional analyses 1,295 CRC cases diagnosed 2008–2019 registered population-based registry (PBCR) database. Cases were grouped into colon cancer. Log-binomial regression was used determine...
Background: Alpha-smooth muscle actin (α-SMA) is an isoform of actin, positive in myofibroblasts and epithelial to mesenchymal transition (EMT) marker. EMT a process by which tumor cells develop be more hostile able metastasize. Progression always followed cell composition extracellular matrix component alteration. Increased α-SMA expression collagen alteration may predict the progressivity ovarian neoplasms. Objective: The aim this research was analyse characteristic stroma In study, PCNA...
Background Recently, SARS-CoV-2 virus with the D614G mutation has become a public concern due to rapid dissemination of this variant across many countries. Our study aims were (1) report full-length genome sequences collected from four COVID-19 patients in Special Region Yogyakarta and Central Java provinces, Indonesia; (2) compare clade distribution Indonesia ( n = 60) March September 2020 (3) perform phylogenetic analysis complete genomes different countries, including Indonesia. Methods...
Abstract Hepatitis virus‐related liver disease increases substantially the mortality rate of patients with HIV on highly active antiretroviral therapy (HAART). Therefore, early diagnosis hepatitis B virus (HBV) and C (HCV) is important. However, prevalence HBV HCV infection in Indonesian infected unknown. this study examined molecular clinical characteristics 126 HIV, mostly HAART, at Dr. Sardjito Hospital, Yogyakarta, Indonesia. The rates triple infection, HIV/HCV co‐infection, HIV/HBV...
Pregenomic RNA (pgRNA) is generated from covalently closed circular DNA (cccDNA) and plays important roles in viral genome amplification replication. Hepatic pgRNA cccDNA expression levels indicate persistence replication activity. This study was aimed to measure hepatic various states of hepatitis B virus (HBV) infection. Thirty-eight hepatocellular carcinoma (HCC) patients, including 14 positive for surface antigen (HBsAg) 24 negative HBsAg but anti-hepatitis core (anti-HBc) antibody, were...
Kidney ischemic/reperfusion (I/R) injury is the main cause of acute kidney (AKI) involving renal function deterioration, architecture damage, and inflammation. This condition may lead to fibrosis with epithelial mesenchymal transition (EMT) myofibroblast formation. Inhibition chronic effects I/R provide effective strategies for treating AKI diseases (CKDs). Chlorogenic acid (CGA) recognized as a powerful antioxidant, anti-inflammatory antifibrotic properties in many conditions. However,...
Abstract Background Transmission within families and multiple spike protein mutations have been associated with the rapid transmission of SARS-CoV-2. We aimed to: (1) describe full genome characterization SARS-CoV-2 correlate sequences epidemiological data family clusters, (2) conduct phylogenetic analysis all samples from Yogyakarta Central Java, Indonesia other countries. Methods The study involved 17 patients COVID-19, including two clusters. determined full-genome using Illumina MiSeq...
Background Breast cancer is a significant public health concern worldwide, including in Indonesia. Little known about the spatial and temporal patterns of breast incidence This study aimed to analyze variations Yogyakarta Province, Methods The used case data from Population-Based Cancer Registry (PBCR) 2008 2019. catchment areas PBCR included 48 subdistricts 3 districts (Sleman, City, Bantul). Age-standardized rates (ASR) were calculated for each subdistrict. Joinpoint regression was detect...
Abstract The outcome of SARS-CoV-2 infection is determined by multiple factors, including the viral, host genetics, age, and comorbidities. This study investigated association between prognostic factors disease outcomes patients infected with S protein mutations. Fifty-one COVID-19 were recruited in this study. Whole-genome sequencing 170 full-genomes was conducted Illumina MiSeq sequencer. Most (47%) had mild symptoms followed moderate (19.6%), no (13.7%), severe (4%), critical (2%)....
Abstract Studies on the characteristics of mutations within hepatitis B virus (HBV) genome, their roles in pathogenesis advanced liver diseases, and involvement host properties HBV‐infected individuals have not been conducted subgenotype B3‐infected populations. For addressing this issue, 40 cases with HBV surface antigen (HBsAg)—positive including cancer cirrhosis (male 31, female 9, age 54.4 ± 11.6‐year‐old), were collected compared 109 chronic 71, 38, 38.0 13.4‐year‐old). Mutations...
We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect vitamin D kidney fibrosis model mice using unilateral ureteral obstruction (UUO). One group was treated with intraperitoneal injection 0.125 mg/kg Calcitriol (UUO+VD). Vascular remodeling quantified based on lumen area and lumen/wall ratio (LWAR) intrarenal arteries Sirius Red staining. ET-1, ETBR, eNOS, CD31 VEGF mRNA expressions were qRT-PCR. Focusing endothelin-1 (ET-1) endothelial cells (EC), siRNA ET-1...
ABSTRACT Hepatitis E is an emerging disease with a high incidence globally. Few data are available on hepatitis virus (HEV) infection in Indonesia. To obtain molecular information HEV two regions of Indonesia different customs and swine breeding conditions, serum samples from 137 farm workers, 100 blood donors (27 fecal also obtained) Yogyakarta (Central Java) 12 64 42 135 local residents 89 119 Tulungagung (East Mengwi (Bali), respectively, our previous study, were compared. Serological...
GB virus C (GBV-C), a human of the Flaviviridae family that is structurally and epidemiologically closest to hepatitis (HCV), has been reported confer beneficial outcomes in HIV-positive patients. However, prevalence GBV-C individuals Indonesia unknown. Since more prevalent anti-HCV positive patients than negative subjects, transmission HCV could be by same method. This study examined molecular characteristics infection HIV Yogyakarta, Indonesia. The among (n = 125, median age 31 years)...
The diagnosis of thyroid neoplasms necessitates the identification distinct histological features. Various education/hospital centers located in cities across Indonesia likely result discordances among pathologists when diagnosing neoplasms.
We aimed to explore the district-level temporal dynamics and sub-district level geographical variations of colorectal cancer (CRC) incidence in Special Region Yogyakarta Province. performed a cross-sectional study using data from population-based registry (PBCR) comprised 1,593 CRC cases diagnosed 2008-2019. The age-standardized rates (ASRs) were determined 2014 population data. trend distribution analysed joinpoint regression Moran’s I statistics. During 2008-2019, increased by 13.44%...
Objective: The diffuse large B-cell lymphoma (DLBCL) has two major molecular subtypes, germinal center B-cell-like (GCB) and non-GCB. These have differing behavior which affects overall patient survival. However, immunohistochemistry based subtyping of Indonesian DLBCLs been limited. This was the focus present study, with a attention on apoptotic index (AI) proliferation (PI) subtypes. Materials Methods: During study period 3.5 years, total 98 cases DLBCL were identified. Molecular subtypes...
Patients undergoing hemodialysis are at increased risk of infection with blood‑borne viruses, including GB virus C (GBV-C) and torque teno (TTV). However, the prevalence genotypic distribution these viruses in assessed patients remains unclear. The present study investigated issues possibility nosocomial transmission among a unit Yogyakarta, Indonesia. GBV‑C RNA was detected 92/161 (57.1%) by nested reverse‑transcription polymerase chain reaction. Phylogenetic analysis 5'‑untranslated region...
Introduction: Lymphoma as a heterogeneous disease has various characteristics not only in the clinical manifestation but also sociodemographic aspect. Epidemiological data with description lymphoma is still unexplored. Objective: This study aimed to provide updated and detailed of emphasis on patient characteristics, hematologic findings. Materials Methods: was an observational descriptive cross-sectional design. The were from medical records Dr. Sardjito Hospital, national referral hospital...