Chromoblastomycosis is a highly neglected deep fungal infection, typically affecting agricultural workers in impoverished rural communities (sub)tropical regions. We present case series of eight individuals with chromoblastomycosis that were identified through teledermatology Sumba, remote island eastern Indonesia. highlight the challenges faced managing complex diseases like underserved communities, and illustrate value telemedicine empowering frontline healthcare improving access to skin care.

Abstract Hemodialysis patients are at an increased risk of acquiring hepatitis B virus (HBV) and C (HCV) infection. However, the prevalence viral infection its genotype distribution among hemodialysis in Indonesia unclear. In order to investigate these issues possibility nosocomial transmission, 161 35 staff members one unit Yogyakarta, Indonesia, were tested for serological virological markers both viruses. HBV surface antigen (HBsAg) was detected 18 (11.2%) two (5.7%). Anti‐HCV 130 (80.7%)...

Abstract Hepatitis virus‐related liver disease increases substantially the mortality rate of patients with HIV on highly active antiretroviral therapy (HAART). Therefore, early diagnosis hepatitis B virus (HBV) and C (HCV) is important. However, prevalence HBV HCV infection in Indonesian infected unknown. this study examined molecular clinical characteristics 126 HIV, mostly HAART, at Dr. Sardjito Hospital, Yogyakarta, Indonesia. The rates triple infection, HIV/HCV co‐infection, HIV/HBV...

Pregenomic RNA (pgRNA) is generated from covalently closed circular DNA (cccDNA) and plays important roles in viral genome amplification replication. Hepatic pgRNA cccDNA expression levels indicate persistence replication activity. This study was aimed to measure hepatic various states of hepatitis B virus (HBV) infection. Thirty-eight hepatocellular carcinoma (HCC) patients, including 14 positive for surface antigen (HBsAg) 24 negative HBsAg but anti-hepatitis core (anti-HBc) antibody, were...

Without early recognition and Kasai procedure, biliary atresia (BA) results in liver cirrhosis leads to either transplantation or death at a young age. We aimed characterize the histopathological findings for prediction of survival BA patients after surgery. retrospectively reviewed all who underwent biopsy during surgery from August 2012 December 2018 Dr. Sardjito Hospital, Yogyakarta, Indonesia. Fifty infants with were ascertained our study, whom 27 males 23 females. The median age...

Mutations in the reverse transcriptase (RT) region of hepatitis B virus (HBV) genome are an important factor low therapeutic effectiveness. Nonetheless, prevalence these mutations HBV strains isolated previously Indonesia has not been systematically examined. Therefore, this study, we investigated profile RT and associations with amino acid changes surface protein treatment-naïve Indonesian carriers. Overall, 96 sequences full-length genomes (genotype B, n = 54; genotype C, 42) were...

Abstract Studies on the characteristics of mutations within hepatitis B virus (HBV) genome, their roles in pathogenesis advanced liver diseases, and involvement host properties HBV‐infected individuals have not been conducted subgenotype B3‐infected populations. For addressing this issue, 40 cases with HBV surface antigen (HBsAg)—positive including cancer cirrhosis (male 31, female 9, age 54.4 ± 11.6‐year‐old), were collected compared 109 chronic 71, 38, 38.0 13.4‐year‐old). Mutations...

ABSTRACT Hepatitis E is an emerging disease with a high incidence globally. Few data are available on hepatitis virus (HEV) infection in Indonesia. To obtain molecular information HEV two regions of Indonesia different customs and swine breeding conditions, serum samples from 137 farm workers, 100 blood donors (27 fecal also obtained) Yogyakarta (Central Java) 12 64 42 135 local residents 89 119 Tulungagung (East Mengwi (Bali), respectively, our previous study, were compared. Serological...

<b><i>Objective:</i></b> The long-term administration of a nucleos(t)ide analogue (NA) for the treatment chronic hepatitis B may encourage emergence viral mutations associated with drug resistance. Minor populations viruses exist before treatment, but are difficult to detect because technological limitations. Identifying minor quasispecies should be useful in clinical management virus (HBV) infection. <b><i>Methods:</i></b> Six treatment-naïve...

GB virus C (GBV-C), a human of the Flaviviridae family that is structurally and epidemiologically closest to hepatitis (HCV), has been reported confer beneficial outcomes in HIV-positive patients. However, prevalence GBV-C individuals Indonesia unknown. Since more prevalent anti-HCV positive patients than negative subjects, transmission HCV could be by same method. This study examined molecular characteristics infection HIV Yogyakarta, Indonesia. The among (n = 125, median age 31 years)...

AIM: To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma. METHODS: This retrospective study was conducted 52 from Department Ophthalmology Pediatrics Dr. Sardjito General Hospital, between 1st January 2014 31st December 2020. Lag defined as delay first sign retinoblastoma diagnosis The subjects > one year were included in case group, while < control group. RESULTS: significantly correlated American Joint Committee on Cancer...

Background: Nasopharyngeal carcinoma (NPC) is a malignancy with high incidence in Southern China and South-East Asia. NPC among males Indonesia estimated around 8.3/100,000 populations. Tobacco smoking common risk factor for cancer, including NPC. P16 one of the key proteins related to activation apoptotic pathways, that commonly change during carcinogenesis. Carcinogenesis often environmental exposure, tobacco smoke. Objective: To analyze association between protein status subjects...

Basal cell carcinoma (BCC) is the most common skin malignancy worldwide. Current evidence suggests tumour-infiltrating lymphocytes (TILs) may influence clinical outcomes of patients with BCC. The present study aimed to profile infiltrative characteristics stromal TILs and regulatory T cells (Treg cells) in tumour centre (TC), periphery (TP), normal adjacent tissue (NAT) A total 111 samples from 43 cutaneous BCC cases were examined for TIL (CD3+) Treg (FOXP3+/CD3+) expression using...

Patients undergoing hemodialysis are at increased risk of infection with blood‑borne viruses, including GB virus C (GBV-C) and torque teno (TTV). However, the prevalence genotypic distribution these viruses in assessed patients remains unclear. The present study investigated issues possibility nosocomial transmission among a unit Yogyakarta, Indonesia. GBV‑C RNA was detected 92/161 (57.1%) by nested reverse‑transcription polymerase chain reaction. Phylogenetic analysis 5'‑untranslated region...

ABSTRAK Malaria merupakan salah satu penyakit yang terus endemik di beberapa daerah Indonesia walaupun pemerintah telah melakukan berbagai usaha untuk mengobati dan mencegah malaria. World Health Organization (WHO) menargetkan insidensi kasus malaria pada tahun 2030 dapat turun hingga 90% dibandingkan 2015.Asmat tinggi menjadi target program eliminasi malaria, namun belum ada publikasi data rinci terkait Asmat, Papua. Penelitian ini bertujuan mengetahui prevalensi Asmat 2017 melihat tren...

Abstract Background Cutaneous melanoma is a rare, aggressive skin malignancy with high mortality rate. Although only contributing 7.6% of the cases worldwide, Asia responsible for 18.6% deaths from cutaneous melanoma. BRAF V600 mutation presents potential prognostic predictor in Unfortunately, studies on that melanoma, particularly nodular subtype, Indonesia are still scarce. This research aimed to investigate prevalence primary Yogyakarta and Central Java, Indonesia. Its association...

Pilomatricoma is a rare benign skin adnexal tumor arising from hair matrix cells. It usually manifests as firm-to-hard, well-circumscribed, nontender nodule often mistaken dermoid cyst. However, its clinical presentation has been reported to mimic keloid. In addition, although it occurs most frequently in the head and neck area, pilomatricoma rarely on auricle. Herein, we case of occurring posterior part 9-year-old girl’s Unlike classic pilomatricoma, closely resembled Nevertheless,...

Primary chordoma of the nasopharynx is an extremely rare malignant tumor notochordal origin in extra-osseous axial skeleton. It presents as a soft tissue mass without involvement skull base bone (clivus) and may mimic other lesions nasopharynx. A 26-year-old male patient presented with nasal obstruction congestion for last 3 years. Physical radiological examination revealed naso-oropharyngeal region. was suspected to be cystic or abscess on imaging. However, histopathological chordoma. We...

Only a limited number of studies have explored the possible associations between tumour grade and mutated genes in clear cell renal carcinoma (ccRCC), we set out to investigate this further using multiple sampling next generation sequencing (NGS) approach series ccRCCs. Multiple regions were sampled from formalin-fixated paraffin-embedded ccRCC blocks seven patients. In 27 samples six patients, performed targeted NGS custom 42-gene panel based on most frequently reported public databases....

BACKGROUND: Hypermethylation of RASSF1A and CDKN2A is one epigenetic factor underlies nasopharyngeal carcinoma (NPC) development. Smoking behavior as an NPC’s risk causes aberrant DNA methylation. promoter hypermethylation from peripheral blood cells correlates with smoking behavior. The use body fluids including a specimen for methylation analyzes are widely developed, less invasive method compared to the tissue biopsy. This study aims observe association between in behavioramong NPC...

ABSTRAK Pada tahun 2013, terdapat 37% kasus anemia pada ibu hamil di Indonesia. Kejadiannya Agats, Asmat, Papua masih merupakan fenomena gunung es yang belum banyak mendapat sorotan. Pusat Kesehatan Masyarakat (Puskesmas) Agats menjalankan Program 1000 Hari Pertama Kehidupan (HPK) sejak 2016 untuk meningkatkan kualitas kehamilan dan kelahiran. Penelitian ini bertujuan mengetahui prevalensi peserta HPK serta menganalisis faktor-faktor berpengaruh terhadap Papua. penelitian deskriptif...

Diagnosing non-gestational uterine choriocarcinoma in children is challenging because of its rarity and nonspecific imaging findings. Herein, we report a case child, which was unexpectedly found during exploratory laparotomy confirmed by histopathological However, the tumor did not respond to chemotherapy.

Introduction: Photoacoustic imaging (PAI) uses nonionizing radiation for tumor features and thus can be used as an alternative method medical without inducing biological effects. The study aimed to characterize a PAI system utilizing 650-nm diode laser detect pathological conditions (benign malignant tumors) in human uterine tissue, including healthy tissue. benign tissue is leiomyoma, which that occurs the middle layer of (myometrium). Meanwhile, type endometrial carcinoma, inner...

A recent extraordinary event of malnutrition in children Asmat, Papua, Indonesia has drawn enormous attention. To help post-emergency rehabilitation, Gadjah Mada University sent a Kuliah Kerja Nyata – Peduli Bencana (KKN-PB) team to Agats, Asmat March 17 April 20, 2018. As part situation analysis, the surveyed nutritional status under five-years-old Asmat. The subjects were five-year-old coming posyandus five areas Agats March-April data sex, age, weight, and height obtained, then form...