A5064195020- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Food Security and Socioeconomic Dynamics
- HIV, Drug Use, Sexual Risk
- Helicobacter pylori-related gastroenterology studies
- Dengue and Mosquito Control Research
- Diverse Scientific Research Studies
- Herpesvirus Infections and Treatments
- Vaccine Coverage and Hesitancy
- Cytomegalovirus and herpesvirus research
- Biosensors and Analytical Detection
- Influenza Virus Research Studies
- Respiratory viral infections research
Airlangga University
2016-2025
Kobe University
2016
Creative Research Enterprises (United States)
2016
Development of complementary and/or alternative drugs for treatment hepatitis C virus (HCV) infection is still much needed from clinical and economic points view. Antiviral substances obtained medicinal plants are potentially good targets to study. Glycyrrhiza uralensis G. glabra have been commonly used in both traditional modern medicine. In this study, extracts roots their components were examined anti-HCV activity using an HCV cell culture system. It was found that a methanol extract its...
Abstract To halt the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), governments around world have imposed policies, such as lockdowns, mandatory mask wearing, and social distancing. The application disinfecting materials in shared public facilities can be an additional measure to control spread virus. Copper is a prominent material with antibacterial antiviral effects. In this study, we synthesized copper nanoparticles (CuNPs) surface coating agent assessed their...
Eight genotypes (A to H) and nine subtypes (adw2, adw4, ayw1, ayw2, ayw3, ayw4, adrq+, adrq-, ayr) of hepatitis B virus (HBV) have been identified worldwide. They appear be associated with geographical distribution, virological characteristics, possibly clinical outcomes. We performed sequence analysis part the S gene entire precore/core HBV isolates obtained from HBsAg-positive blood donors in Papua Province, Indonesia. Phylogenetic sequences revealed that 23 (85.2%) 27 tested belonged...
Abstract Background Coronavirus disease 2019 (COVID-19) is a global health problem that causes millions of deaths worldwide. The clinical manifestation COVID-19 widely varies from asymptomatic infection to severe pneumonia and systemic inflammatory disease. It thought host genetic variability may affect the host’s response virus thus cause severity SARS-CoV-2 requires interaction with its receptor complex in cells before infection. transmembrane protease serine 2 (TMPRSS2) has been...
Abstract Background Hepatitis C virus (HCV) is a major cause of liver disease and potential substantial morbidity mortality worldwide. The overall prevalence HCV infection 2%, representing 120 million people Current standard treatment using pegylated interferon ribavirin effective in only 50% the patients infected with genotype 1, associated significant side effects. Therefore, it still importance to develop new drugs for HCV. Antiviral substances obtained from natural products, including...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of COVID-19 pandemic in Here, estimate magnitude SARS-CoV-2 infection East Java, Indonesia, we investigated immunoglobulin G (IgG) antibodies. We enrolled 1,819 individuals from June December 2020 and observed that subjects’ overall IgG antibody was 11.4% (207/1,819)....
Understanding the co-occurrence of respiratory viruses is crucial for patient management and effective control strategies. This study aimed to retrospectively reveal prevalence influenza A B among suspected COVID-19 patients. We examined presence Influenza RNAs in 1099 remnant samples diagnostic patients during first wave East Java using a multiplex PCR one-step TaqMan real-time systems. found that 7.3% 1.5% subjects were positive B, respectively, while 13.1% had previously tested...
Abstract Hemodialysis patients are at an increased risk of acquiring hepatitis B virus (HBV) and C (HCV) infection. However, the prevalence viral infection its genotype distribution among hemodialysis in Indonesia unclear. In order to investigate these issues possibility nosocomial transmission, 161 35 staff members one unit Yogyakarta, Indonesia, were tested for serological virological markers both viruses. HBV surface antigen (HBsAg) was detected 18 (11.2%) two (5.7%). Anti‐HCV 130 (80.7%)...
To determine anti-viral activities of three Artocarpus species: altilis, camansi, and heterophyllus (A. heterophyllus) against Hepatitis C Virus (HCV). Antiviral the crude extracts were examined by cell culture method using Huh7it-1 cells HCV genotype 2a strain JFH1. The mode action for anti-HCV was determined time-of-addition experiments. effect on RNA replication accumulation in analyzed quantitative reverse transcription-PCR western blotting, respectively. dichloromethane (DCM) extract A....
Group A rotavirus (RVA) is the most important cause of severe gastroenteritis among children worldwide, and effective RVA vaccines have been introduced in many countries. Here we performed a molecular epidemiological analysis infection pediatric patients East Java, Indonesia, during 2015-2018. total 432 stool samples were collected from hospitalized with acute gastroenteritis. None this cohort had immunized an vaccine. The overall prevalence was 31.7% (137/432), significantly more prevalent...
Abstract Four subtypes ( adw, adr, ayw , and ayr ) eight genotypes (A to H) of the hepatitis B virus (HBV) have been identified. They appear be associated with particular geographic distribution, ethnicity, possibly clinical outcomes. In this study, surface antigen (HBsAg) subtyping HBV genotyping were carried out on sera obtained from HBsAg‐positive carriers, including healthy blood donors; patients acute hepatitis, chronic liver cirrhosis, hepatocellular carcinoma; hemodialysis all located...
Each hepatitis B virus (HBV) genotype and subgenotype is associated with a particular geographic distribution, ethnicity, anthropological history. Our previous study showed the novel HBV subgenotypes C6 (HBV/C6) D6 (HBV/D6), based on S gene sequences of isolates in Papua, Indonesia. The present investigated complete genome sequence 22 strains from Papua subjected them to molecular evolutionary analysis. A phylogenetic analysis revealed that 9 out were classified as HBV/C6, 3 HBV/D6, HBV/B3....
Japanese encephalitis virus (JEV) is a fatal disease in Asia. Pigs are considered to be the effective amplifying host for JEV peridomestic environment. Bali Island and Java Indonesia provide model assess effect of pigs on transmission, since pig density nearly 100-fold higher than Java, while geographic climatologic environments equivalent these areas. We surveyed antibodies among 123 Mengwi (Bali) 96 Tulungagung (East Java) 2008 by hemagglutination-inhibition (HAI) test. Overall prevalences...
A universal hepatitis B vaccination program for infants was adopted in Indonesia 1997. Before its implementation, the prevalence of surface antigen (HBsAg)–positive individuals general population approximately 5–10%. The study aimed to investigate virus (HBV) serological status and molecular profile among children, 15 years after adoption a infant Indonesia. According Local Health Office data five areas, percentages children receiving three doses vaccine are high (73.9–94.1%), whereas birth...
Background: Monkeypox is a zoonosis. The disease has similar appearance to chickenpox caused by the varicella-zoster virus (VZV). On May 9th 2019, there was one laboratory-confirmed case of monkeypox reported in Singapore. A man also suspected having on June 1st 2019 Surabaya, Indonesia, neighboring country. Objective: To report with differential diagnosis chickenpox. Case: 51-year-old male after His chief complaint multiple blisters his body. From dermatological status facial, trunk and...
The coronavirus disease 2019 (COVID-19) pandemic that has a significant rapid transmission is an international public health concern. Several dengue-endemic countries reported similar clinical and laboratory features between COVID-19 dengue in the early incubation period, thus discerning infection difficult. As country, Indonesia also poses same challenge during outbreak. This current study analyzed IgG IgM profiles from patients by using serological SARS-CoV-2 test. In addition, 38 sera...
Universal childhood hepatitis B vaccination was introduced in Indonesia 1997; by 2008, coverage estimated to be 78%. This study aimed investigate the serologic status and virologic characteristics of virus (HBV) among children East Java. A total 229 healthy born during 1994–1999 were enrolled this study. Overall, 3.1% positive for surface antigen (HBsAg) 23.6% antibody HBsAg (anti-HBs). HBV DNA detected 5 222 HBsAg-negative carriers, which suggested cases occult infection. single amino...
ABSTRACT Quasispecies of hepatitis B virus (HBV) with variations in the major hydrophilic region (MHR) HBV surface antigen (HBsAg) can evolve during infection, allowing to evade neutralizing antibodies. These escape variants may contribute chronic infections. In this study, we looked for MHR quasispecies using ultradeep sequencing and evaluated relationship between these clinical manifestations infected patients. We enrolled 30 Indonesian patients infection (11 19 advanced liver disease)....
Rotavirus A (RVA) is a major cause of gastroenteritis in infants and young children. After vaccine introduction, RVA surveillance has become more important for monitoring changes genotype distribution, the semi-nested multiplex-PCR popular method genotyping. In particular, VP7 primer set reported by Gouvea colleagues 1990 still widely used worldwide as recommended WHO regional national reference laboratories. However, this yielded some mistakes with recent epidemic strains. The newly emerged...
Japanese encephalitis virus (JEV) is transmitted between swine, migratory birds, and Culex mosquitoes, has circulated indigenously in Asia for almost a century. Despite being the country with highest JEV diversity, surveillance targeting of Indonesia's vectors scarce. This study collected mosquitoes from several locations Tabanan Regency, Bali Island, Indonesia. We captured classified 3,032 adult into seven species, vishnui subgroup making up approximately 90% total. was identified by...