A5039508857- HIV Research and Treatment
- Mosquito-borne diseases and control
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- Medicinal Plant Research
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Diverse Scientific Research Studies
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- Blood donation and transfusion practices
- Inflammatory Biomarkers in Disease Prognosis
- Digital Imaging for Blood Diseases
- Dengue and Mosquito Control Research
- Antibiotic Resistance in Bacteria
- HIV/AIDS drug development and treatment
- Blood transfusion and management
- COVID-19 diagnosis using AI
- Healthcare Quality and Satisfaction
- Sepsis Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Influenza Virus Research Studies
- Biological Research and Disease Studies
- Hematological disorders and diagnostics
ADA University
2024
Universitas Gadjah Mada
2013-2023
Rumah Sakit Umum Pusat Dr. Sardjito
2015-2016
Abstract Background Transmission within families and multiple spike protein mutations have been associated with the rapid transmission of SARS-CoV-2. We aimed to: (1) describe full genome characterization SARS-CoV-2 correlate sequences epidemiological data family clusters, (2) conduct phylogenetic analysis all samples from Yogyakarta Central Java, Indonesia other countries. Methods The study involved 17 patients COVID-19, including two clusters. determined full-genome using Illumina MiSeq...
Abstract Background Severe acute respiratory infection (SARI) accounts for a large burden of illness in Indonesia. However, epidemiology SARI tertiary hospitals Indonesia is unknown. This study sought to assess the burden, clinical characteristics, and etiologies concordance diagnosis with confirmed etiology. Methods Data samples were collected from subjects presenting as part febrile Illness requiring hospitalization (AFIRE). In hospitals, was ascertained chart review. Samples analyzed...
<ns3:p><ns3:bold>Background:</ns3:bold> Interleukin-6 (IL-6) is a pro-inflammatory cytokine that produced at varying levels in patients with coronavirus disease 2019 (COVID-19). The neutrophil–lymphocyte ratio (NLR) one of the new inflammatory markers COVID-19. This study aimed to evaluate differences IL-6 level and NLR mild severe COVID-19 assess their correlation severity COVID-19.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> A total 91 were divided into (n = 57) 34) groups. measured using...
ABSTRACT Introduction: Dengue is a mosquito borne viral febrile illness with high incidence rate of approximately 50 million cases infection world wide every year. virus can infect many cells, e.g. monocytes, dendritic Kuppfer B cells including bone marrow and lung. Leukocytes plays an important roles in eliminating dengue especially monocytes. However, sometimes attack the monocytes uses them for replication causing monocyte to unde go apoptosis order prevent spreading by certain...
Microscopic examination is the backbone of malaria diagnosis and treatment evaluation in Indonesia. This test has limited ability to detect at low parasite density. Inversely, nested polymerase chain reaction (PCR) can parasites a density below microscopic examination's detection limit. The objective this study compare PCR results when being used identify suspected patients who underwent dihydroartemisinin-piperaquine (DHP) therapy last 3-8 weeks with or without symptoms Sumba Barat Daya,...
A significant decrease in antibody titres several months after COVID-19 primary vaccination end-stage kidney disease (ESKD) patients receiving maintenance haemodialysis has recently been reported. The waning led to the recommendations for a booster dose increase vaccination. Consequently, it is crucial analyse long-term humoral immune responses and assess immunogenicity safety of doses (HD) patients.Patients on who received vaccine CoronaVac (Sinovac) were administered with BNT162b2...
<ns3:p><ns3:bold>Background:</ns3:bold> Systemic lupus erythematosus (SLE) is a chronic multisystem rheumatic disease characterized by developing autoantibodies against nucleus antigen. It has broad range of clinical symptoms and the potential to affect nearly all organs tissues. Pulse dosage methylprednisolone (MEP) immunosuppression modality for life-threatening or organ-threatening SLE. However, it challenging estimate MEP response rate. We combine symptoms, routine laboratory...
Sepsis is a systemic inflammatory response due to severe infection. The immune rises after the local immuneresponse does not successfully eliminate antigen. Procalcitonin (PCT) has been known as marker for bacterial aimof this study was know whether PCT could be used predictor of clinical outcome in sepsis incidence. A prospective cohort designwas study. subjects were patients entering Internal ward who met inclusion and exclusion criteria examinedfor basic data collection. For assessment...
Dengue infection is one of the infectious diseases which become a health problem in world. Platelets play an important role pathogenesis dengue. The quantity platelet related to dengue were often discussed but quality rarely discussed. activation platelets can be observe indirectly through changes MPV. Aim this study analyze prevalence ratio MPV enhancement hemorrhagic fever (DHF) compared (DF). This observational analytical with cross-sectional design DHF DF. subjects suspected patients...
Introductions: Nowadays dengue infection is at present one of the most common mosquito-borne viral diseases humans worldwide. Initially, Dengue infections were primarily recorded when they occurred as epidemics in tropical and subtropical countries. Monocyte/macrophage central to pathogenesis fever origin hemorrhagic fever. Increased activation monocytes greater numbers DEN-infected cells associated with more severe Dengue, implicating a role for monocyte immunopathogenesis. Thus, knowledge...
Cellular immunity plays an important role in viral infection. The activation of effector T-lymphocytes and the release cytokines define course dengue CD4⁺ T-lymphocyte induces immunopathology via various mechanisms; however, its kinetics different onset fever disease severity are not fully understood. This study was conducted to observe CD4 + level among infected patients obtain absolute cell count relative percentage T-lymphocyte. a descriptive on thirty six who met WHO-1997 criteria...
ABSTRACT Introduction: Dengue infection is major annual public health problem in Indonesia. NK cells have a role cellular immunity to viral infection, however only few studies of and were conducted vivo especially Objectives: To explore the kinetics CD 69 expression on during acute phase dengue infection. Methods: Observational cohort study Dr. Sardjito Hospital was conducted. Clinical data laboratory collected measure number activated (CD69) using flowcytometry. The percentage CD69 then...
ABSTRACT Introduction: Dengue fever can be graded into dengue (DF), hemorrhagic (DHF) and shock syndrome (DSS). The CD8+ T lymphocytes mediate antiviral activity by producing cytokines directly destroyed the virus infected cells. This study focuses in observing kinetics of absolute relative count patients. Objectives: To observe relative Methods: research design used is a descriptive study. measures observes from day 2 to 7. was determined using flowcytometry. Data analyzed...
Human Immunodeficiency Virus (HIV) adalah retrovirus RNA yang dapat menyebabkan penyakit klinis, yaitu Acquired Syndrome (AIDS). Transmisi virus dari ibu ke anak (mother to child transmission/MTCT) terjadi melalui darah maternal, sekresi saluran genital, dan ASI. Risiko penularan HIV bayi ditekan hingga 2% dengan program PMTCT. Tulisan ini bertujuan untuk memaparkan tentang peran laboratorium dalam mendukung PMTCT HIV. Dalam hal memegang peranan penting mendeteksi secara dini diikuti...
Background Rubella infection in pregnancy can cause congenital rubella syndrome (CRS), and one common defect of CRS is hearing loss. However, screening not routinely performed Indonesia. While the number reported cases Indonesia increasing, it still difficult to identify all cases. This study aims through a newborn screening. Materials Methods descriptive was conducted at Dr. Sardjito Hospital, Yogyakarta, The subjects were recruited from September 1, 2013 November 19, 2013. period January...
Infeksi HIV/AIDS masih menjadi tantangan global. Pengobatan antiretroviral (ART) berperan dalam menurunkan replikasi virus,menurunkan tingkat kematian infeksi oportunistik dan meningkatkan kualitas hidup orang yang dengan HIV/AIDS. Meskipundemikian data terkait respons virologis imunologis termasuk aktivasi imun sangat terbatas. Penelitian ini bertujuan untukmengetahui pasien HIV setelah 6 bulan memulai pengobatan ARV. Subjek dari penelitian observasionalprospektif adalah 44 belum pernah...
Dengue infections are currently one of the most rapidly emerging arboviral in world. During this time emphasis platelets only limited about number and very rarely discuss quality (activation dysfunction). Changes PDW reflects activation platelets. Aim study is to analyze prevalence ratio enhancement dengue hemorrhagic fever (DHF) compared (DF). This was a cross-sectional DHF DF. The subjects were suspected patients who meet inclusion exclusion criteria. Venous blood collected for automatical...
Despite its life saving potential, regrettably, blood transfusion has yet to be optimally applied in Indonesia. Funding difficulties and both public professional lack of knowledge hinders progress. More lives can saved by using a safer, more proper, specialized procedure. Plateletpheresis, one method obtain platelet products, requires different donation procedure than that whole blood-derived platelet. High quality plateletpheresis product will positively impact the efficacy recovery...
Background: Many academicians in Yogyakarta, Indonesia, face the increased potential for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) transmission academic populations. Seroprevalence data can represent number of infections showing proportion people exposed and those potentially immune to virus provide evidence public health policymakers. The seroprevalence SARS-CoV-2 population Universitas Gadjah Mada (UGM) remains unknown, raising concerns about status among population. A...
The number of HIV-AIDS patients in Indonesia has considerably increased. life expectancy get s longer the presence antiretroviral treatment (ARV). Most opportunistic infections HIV infection are found to be Tuberculosis (TB-HIV). Antiretroviral and anti - tuberculosis will improve quality people living with (PLWHA). Regulatory T cells (Tregs) were suggested play a role immune response TB-HIV. This study aims investigate Tregs TB-HIV, their clinical changes, other immunological aspects such...
Introduction: Dengue is the most common disease of mosquito-borne infection. According to World Health Organization, it estimated that 50 million cases ofdengue infection have been reported annually. Macrophages andmonocyte are thought play an important role in dengue both as primary targets viral and a source immunomodulatory cytokines.Whenmonocytes infected by viruses, processed virus lyses expressed antigen on its surfacemembrane bind together with HLA class II molecules....