A5085874792- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Public Health and Nutrition
- Glioma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Gestational Trophoblastic Disease Studies
- Brain Metastases and Treatment
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Maternal and fetal healthcare
- Parathyroid Disorders and Treatments
- Tendon Structure and Treatment
- Marriage and Family Dynamics
- Head and Neck Cancer Studies
Dr. Hasan Sadikin General Hospital
2016-2025
Padjadjaran University
2015-2025
Molecular Theranostics (United States)
2024
Backgrounds: In this research, we want to find out whether extracellular vesicles (EVs) from adipose-derived mesenchymal stem cells (MSCs) can improve ligament–bone integration after primary Anterior Cruciate Ligament (ACL) repair by performing immunological and biomechanical tests. Methods: All of the rabbits underwent ACL resection at proximal attachment femur bone, then were divided into four groups. We performed an ELISA examination tissue bone–ligament interface iNOS, CD206, MMP-3,...
Abstract Background Differentiated thyroid carcinoma (DTC) generally has a favourable prognosis with standard treatments; however, the risks of local recurrence and distant metastases remain concern, affecting substantial proportion patients. Radioactive iodine (RAI) refractoriness further complicates DTC management, leading to substantially reduced survival rates. In this study, we aimed identify anexelekto (AXL) expression TERT promoter mutation as potential predictors RAI-refractory DTC....
Cardiac myxomas (CM) are benign primary tumors typically found in the left atrium, but biatrial exceptionally rare, comprising only 3-5 % of cases. This report highlights rarity a young patient, importance early recognition due to risk thromboembolic events, which can lead stroke. Excellent surgical intervention is needed prevent CM recurrences. An 11-year-old girl presented with sudden onset left-sided hemiparesis, aphasia, right-sided facial drooping, cephalgia, palpitations, nausea, and...
Background The World Health Organization (WHO) classification of central nervous system (CNS) tumors is a major advance toward improving the diagnosis adult brain tumors. Despite promise isocitrate dehydrogenase (IDH) mutations as an important biomarker for glioblastoma, not all institutions have ready access to mutation detection polymerase chain reaction (PCR) methods, and deoxyribonucleic acid (DNA) sequencing may be problematic in very small biopsies. However, simultaneous evaluation...
Background and Aim: Anterior cruciate ligament (ACL) repair offers several theoretical advantages over reconstruction, including preservation of native proprioception reduced donor-site morbidity. However, the current experimental models are predominantly limited to ACL leaving a critical gap in research. This study introduces novel rabbit model evaluate osteointegration mechanical strength at tendon/ligament-bone interface following reconstruction. Materials Methods: Six male New Zealand...
BRAFV600E and RAS mutations are the most common gene in papillary thyroid carcinoma (PTC) that may be correlated with its biological behavior. There still limited data about Indonesia. This study aims to determine prevalence of mutations, their association clinicopathologic characteristics.Patients who had total thyroidectomy from 2019 2021 those met our criteria underwent PCR DNA sequencing analysis for BRAFV600E, BRAFK601E, exon 2 3 NRAS, HRAS, KRAS. Analyses were performed associations...
Background . The diagnosis of Osteosarcoma (OSA) is not always straightforward. OSA may resemble Other Primary Bone Tumours (OPBT). osteosarcoma sometimes difficult especially in a very small specimen. Immunohistochemistry one ancillary testing types that can help the many tumours. aim this study was to evaluate validity Osteocalcin (OCN) and Alkaline Phosphatase (ALP) immunohistochemistry discriminating from OPBT. Method This included 50 selected human primary bone tumours, 25 cases...
Abstract Background The occurrence of castration‐resistant prostate cancer (CRPC) varies in patients with advanced (PCa) undergoing androgen deprivation therapy (ADT). rate CRPC may be related to the presence stem cells (CSC). Thus, this study aims evaluate CSC markers (CD44 and CD133) histopathology tissue at time diagnosis their correlation PCa within 2 years ADT. Method A retrospective case‐control was conducted incidence years. inclusion criteria were who had received treatment ADT a...
Cytological and molecular examinations are among the most important in cancer diagnosis. 96% alcohol is a fixative solution commonly used by clinicians for cytological samples because of its accessibility affordability. Cellblock preparation from cytology specimen may increase morphology detail be further biomarker analysis. E-cadherin an adhesion protein expressed cell membrane carcinoma. Ki67 nuclei malignant cells that as proliferation marker.This study was designed to investigate effect...
Background: Breast cancer is the most common in Indonesia, a low-middle income country Southeast Asia. We provide regional hospital-based registry of central hospital West Java, Indonesia. This study aims to characterize presentation, diagnosis, evaluation, and management breast cancer; develop Java monitor care patterns; evaluate treatment outcomes.Methods: The data were collected from medical records deposited Hasan Sadikin General Hospital Information System. team has been contracted...
Cementoblastoma, a rare odontogenic benign tumor characterized by calcified cementum-like deposits produced cementoblasts fused with the tooth root, represents minute proportion of all tumors, prevalence ranging from less than 1% to 6.2%. We present case 19-year-old female experiencing pain, progressive swelling, and facial asymmetry in left lower region over 1 year ago. Physical examination revealed diffuse swelling mandibular area, demonstrating tenderness bony hardness on palpation....
The diagnosis of thyroid neoplasms necessitates the identification distinct histological features. Various education/hospital centers located in cities across Indonesia likely result discordances among pathologists when diagnosing neoplasms.
Background: Hypoxia caused by exercise condition may alter PGC-1α and HIF-1α expression in cardiac cells. Both factors are transcriptional which play a role conserving energy during metabolic process. However, there is less information about the effects of long term moderate intensity such as swimming on Objectives: Aim this study to observe effect force gene muscle mice. Methods: Male BALBc mice were divided into two groups (n = 10): control (C) (ST). ST group was subjected for 4 weeks,...
Pilomyxoid astrocytoma (PMA) is a recently described entity with similar features to pilocytic but rare occurrence. As new diagnosis, no treatment guideline of PMA has been established; generally, as for any low-grade gliomas, radical resection performed if the location favorable. In this report, we wished share our experience treating PMA. The authors presented case 7-year-old girl bitemporal hemianopia. From history, patient had 4-month history headache, following nausea and projectile...
Gliomas are the most prevalent type of primary brain tumors. Clarifying correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand (PD-L1) L-type amino acid transporter (LAT-1) with respect to overall survival in patients. Immunohistochemistry (IHC) results from 25 samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens diagnosed as grade II,...
The Cancer Genome Atlas (TCGA) has classified papillary thyroid carcinoma (PTC) into indolent RAS-like and aggressive BRAF-like based on its distinct driver gene mutations. This retrospective study aimed to assess clinicopathology pERK1/2 expression variations between PTCs establish predictive models for BRAFV600E RAS-mutated PTCs. A total of 222 underwent immunohistochemistry staining Sanger sequencing analyze the BRAF RAS genes. Multivariate logistic regression was employed develop...
Nasopharyngeal Carcinoma (NPC) is the most common cancer in head and neck. Grading of NPC based on keratinization, growth, cell junction, it can be classified into well differentiated, moderately poorly undifferentiated. On other hand, staging UICC/AJCC system divided Stage I-IVC. This classification TNM that related to ability cells invade normal cells. study was conducted from May June 2017 Oncology Clinic Otorhinolaryngology-Head Neck Surgery Department Pathology Anatomy Hasan Sadikin...
To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation.
Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran klinis dan histopatologi pasien kanker ovarium di RSHS tahun 2019-2020. Metode: deskriptif dilaksanakan RSUP Dr. Hasan Sadikin Bandung dengan menggunakan data rekam medis yang didiagnosis secara Sampel dipilih metode total sampling. Hasil: menunjukan dari 140 pasien, mayoritas berusia 46-55 (31,4%), multipara (60,7%), IMT normal (57,1%). Pasien mengeluhkan adanya benjolan pada abdomen (100%) karakteristik kistik sebagian padat...
Lymphadenopathy is enlarged lymph nodes caused by infection, inflammation or malignancy. On HIV positive patients, lymphadenopathy one of the most common clinical manifestations and it usually persistent. Fine-needle aspiration biopsy (FNAB) an effective cytology technique in determining diagnosis lymphadenopathy. This study aimed to describe cytopathology patients. a descriptive 21 cases patients with who underwent FNAB examination Anatomical Pathology Department Dr.Hasan Sadikin Hospital...
BACKGROUND Gestational trophoblastic disease (GTD) encompasses a group of disorders that arise from abnormal growth tissue. The spectrum GTD includes 2 major groups: benign and malignant. form is hydatidiform mole, either complete or partial; the malignant forms, referred to as gestational neoplasia (GTN), consist invasive moles, choriocarcinomas, placental site tumors, epithelioid tumors. Most patients who undergo evacuation mole by curettage have disease-free period before new tumor...
Apocrine carcinoma is a rare tumor of the skin that typically arises in areas rich apocrine glands. In our report, 64-year-old man came to emergency department with complaint an enlarging, tender mass scrotum growing over previous 3 months associated discomfort. Tumor markers were checked, and elevation lactate dehydrogenase (LDH) beta-human chorionic gonadotropin (HCG) was found. The patient initially diagnosed testicular cancer infiltration scrotum. Wide excision bilateral orchidectomy...