Introduction: Dent disease (DD) is characterized by a triad of low-molecular-weight proteinuria, hypercalciuria, and nephrocalcinosis/nephrolithiasis. However, some cases were confounded other clinical symptoms signs, namely hypokalemia rickets, which resulted in misleading diagnoses. A diagnosis DD could be delayed even high-resource countries due to its variability phenotypes rarity, causing lack awareness both medical practitioners parents. Moreover, low-resource countries, laboratory...

Limited evidence exists regarding the clinical characteristics of auricular angiosarcoma in pediatric population. To our knowledge, this represents inaugural case report early childhood. This aims to delineate unique features and findings associated with angiosarcoma. We a 7-year-old girl presented 2-year history an enlarging, intermittently painful purplish-red mass left ear canal undergo surgery adjuvant chemotherapy. Although rarity, can manifest patients, necessitating vigilant...

Multiple wasp stings may cause fatal complications, such as anaphylactic reactions, intravascular hemolysis, rhabdomyolysis, acute kidney injury (AKI), increased levels of liver enzymes, clotting abnormalities, or even death. AKI-related mortality due to multiple reach 25%, occurring within the early onset disease; therefore, renal function should be continuously monitored first few days following stings. Herein, we report 2 cases AKI (<i>Vespa affinis</i>). In both cases,...

Abstract Background The occurrence of castration‐resistant prostate cancer (CRPC) varies in patients with advanced (PCa) undergoing androgen deprivation therapy (ADT). rate CRPC may be related to the presence stem cells (CSC). Thus, this study aims evaluate CSC markers (CD44 and CD133) histopathology tissue at time diagnosis their correlation PCa within 2 years ADT. Method A retrospective case‐control was conducted incidence years. inclusion criteria were who had received treatment ADT a...

Primary cardiac lymphoma (PCL) is a very rare disease and most commonly found among immunocompromised patients. Its manifestations are non-specific, leading to delayed diagnosis poor prognosis. However, chemotherapy could improve survival, which makes early prompt crucial. This report of case PCL on 73-year-old man who benefit from debulking surgery.A presented with worsening dyspnoea over the last 2 months. A 7.2 × 10.2 cm intramural tumour was extending right atrium ventricle. It...

Pediatric kidney transplantation was only introduced in Indonesia 2013. We therefore aimed to assess the characteristics and outcomes of transplants performed from its inception January 2019.The study had a dual-center retrospective design. examined records transplant recipients then calculated patient graft survival rates by Kaplan-Meier analysis with 95% confidence intervals (95% CI).In total, 12 transplantations were eleven children during period; among these, ten boys, nine renal failure...

Abstract Background Androgen deprivation therapy (ADT) is a standard treatment for advanced prostate cancer (PCa). However, PCa recurrence and progression rates during ADT are high. Until now, there has been no evidence regarding when begins. This study evaluated the gene expression of intraprostatic androgen receptor (AR) steroidogenic enzymes in early stages ADT. Methods Prostate tissue samples were taken from patients with urinary retention who received (ADT-PCa; n = 10) further...

Studies investigating the effect of rituximab in children with nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS) have reported conflicting results, some concluding that patients may require additional immunosuppressive therapy achieve and/or maintain long-term remission. We report successful treatment pediatric FSGS infusions, followed by maintenance immunosuppression mycophenolic acid (MPA) and a calcineurin inhibitor (CNI) 1 patient refractory steroid-resistant NS...

Wasp stings occur frequently in developing countries and often lead to fatal outcomes due the effects of wasp venom. Hemolysis rhabdomyolysis complicate result acute kidney injury (AKI). We report a case multiple leading AKI organ dysfunction syndrome (MODS) 9-year-old Indonesian girl. Kidney biopsy revealed tubular necrosis interstitial nephritis. Despite delayed admission, she recovered 33 days after 3 intravenous steroid administration, eight sessions intermittent hemodialysis, two plasma...

Abstract Background Bladder cancer is characterized by high recurrence and progressivity. E-cadherin serves as one of the most important molecules involved in epithelial cells’ cell-to-cell adherence, suggested to inhibit tumor cell progression. This study aims investigate association between expressions with bladder progressiveness 3 years. Methods was a retrospective cohort involving patients Cipto Mangunkusumo Hospital, Jakarta. Diagnosis cancers confirmed histopathological...

This study aims to describe the factors associated with dysplastic changes in sinonasal inverted papilloma (SIP) including somatic EGFR mutation, FoxM1 expression, HPV status, and their association changes.A cross-sectional, analytical was conducted comprising 34 samples of histologically-confirmed diagnosis SIP. The were further grouped into 2 groups: 20 without changes, 14 changes. numbers positively-expressed cells, status compared among two groups using appropriate comparative...

In this case report, a 40-year-old male patient with persistent and productive cough lasting over 2 weeks, accompanied by dyspnea, who received an anti-tuberculosis drug regimen for 12 months without any clinical improvement at different hospital before being referred to Persahabatan Central General Hospital was presented. In-depth clinical, radiological investigations, the periodic acid-Schiff (PAS)-positive related pulmonary alveolar proteinosis (PAP) confirmed through transbronchial...

BackgroundProstate adenocarcinoma is second most common malignancy in men and fourth leading death cause from worldwide. Prostate biopsy the gold standard for diagnosing this disease. However, difficulty of sampling a weakness procedure. In Cipto Mangunkusumo hospital, technology now available with robotic techniques sampling, which expected to increase prostate accuracy. This study was determine case profile Department Pathology Anatomic Hospital 10 years examine differences preparations...

Background: Carcinogenesis of adenocarcinoma the prostate occurs due to dysregulation zinc level within cells. Intracellular molecules influx is regulated by a transporter protein ZIP1, whose non-presence predicted inhibit apoptosis, thus leads development adenocarcinoma. Methods: This study was aimed analyse correlation ZIP1 and Caspase-3 expression in on its grading as represented Gleason Score. cross-sectional, retrospective analytical 31 Formalin-fixed, paraffin-embedded tissue that...

We report the experience with patients of urachal adenocarcinoma bladder, a rare malignancy in urinary treated laparoscopic partial cystectomy. Solitary transitional cell carcinoma (TCC) dome/anterior wall bladder some cases. As compared to radical surgery, cystectomy has lower morbidity rate and similar oncological outcomes. present our (LPC) adenocarcinoma. Until being admitted hospital, 60-year-old woman had been suffering from painless, sporadic gross hematuria for previous year. Her...

Bladder exstrophy is a rare congenital anomaly while, bladder adenocarcinoma mucinous type of cancer, with aggressive behavior and inadequate response to radiation chemotherapy. In extremely cases, untreated could transform into adenocarcinoma.

Seventy percent of anterior prostate cancer cases are diagnosed during rebiopsy. MRI-US fusion transperineal robotic biopsy is an emerging diagnostic method and might be effective one in diagnosing cancers difficult sites such as the zone. We report a case high grade previously undetected by transrectal biopsy, with biopsy. This suggests that valuable especially - region this imperative suspicious prior negative

Renal cell carcinoma (RCC) skin metastasis is a rare disease. However, there are no data on the effect of Tyrosine Kinase Inhibitor (TKI) its treatment. A 54-year-old male patient with renal developed subcutaneous three months after radical nephrectomy and was discoloration or pain. Furthermore, an excision biopsy confirmed metastatic lesion, pazopanib initiated as treatment method. After 1-month treatment, ulceration subsided stopped. Similarly, follow-up PET scan performed almost year...

BACKGROUND: Renal tumor biopsy is beneficial as it capable of distinguishing between histological types renal tumor; hence, plays an important role in deciding the best therapy regimen. AIM: This study aims to evaluate clinical experiences Cipto Mangunkusumo National Referral Hospital (RSCM), with both a percutaneous and open approach. It also analyze indications, results, intraoperative information, complications two approaches. METHODS: was conducted using retrospective cohort design;...

Introduction: Prostatic ductal adenocarcinoma (PDA) is rare, representing approximately 0.4 to 0.8% of all prostate malignancies. It usually occurs in the prostatic urethra around verumontanum, its prognosis generally considered be worse compared acinar adenocarcinoma.Case description: We present a 75-year-old male with PDA an elevated PSA level. histologically characterized by pseudostratified columnar cells. associated aggressive behavior overall poor prognosis. Although normal common...

Background: Clinically significant prostate cancer (csPCa) is a type of that has moderate to high probability local progression, metastasis, recurrence, and death, as well more aggressive management.Objective: To diagnose between csPCa non-csPCa using the apparent diffusion coefficient ratio (rADC) prostate-lesion-to-urine.Materials Methods: This study was conducted at Cipto Mangunkusumo National General Hospital June 2019 March 2021. Prostate lesions were analyzed with imaging-reporting...

<ns3:p><ns3:bold>Background:</ns3:bold> Upper tract urothelial carcinoma (UTUC) is a malignant disease of the cell lining upper urinary from renal calyces, pelvises, and ureter down to ureteral orifice. Urothelial multifocal tumor which tends reoccur after treatment. Radical cystectomy shows that recurrence occurs in 0.75% 6.4% patients. The occurrence contralateral UTUC nephroureterectomy rarer with prevalence 0.5%.</ns3:p><ns3:p> <ns3:bold>Case presentation: </ns3:bold>The case 43-year-old...