A5030247620- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
- Medical and Health Sciences Research
- Retinal Development and Disorders
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Advanced MRI Techniques and Applications
- Ultrasound in Clinical Applications
- Congenital Heart Disease Studies
- Health and Medical Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Social and Demographic Issues in Germany
- Neurology and Historical Studies
- Psychoanalysis and Psychopathology Research
University of Münster
2017-2019
University Hospital Münster
2019
Max Planck Institute for Molecular Biomedicine
2007-2017
Abstract VEGFR-2/Notch signalling regulates angiogenesis in part by driving the remodelling of endothelial cell junctions and inducing migration. Here, we show that VEGF-induced polarized elongation increases perimeter decreases relative VE-cadherin concentration at junctions, triggering formation actin-driven junction-associated intermittent lamellipodia (JAIL) under control WASP/WAVE/ARP2/3 complex. JAIL allow new adhesion sites are critical for migration monolayer integrity. Whereas...
Actin-binding proteins are essential for linear and branched actin filament dynamics that control shape change, cell migration, junction remodeling in vascular endothelium (endothelial cells [ECs]). The epithelial protein lost neoplasm (EPLIN) is an actin-binding protein, expressed as EPLIN-α EPLIN-β by alternative promoters; however, the isoform-specific functions not yet understood. Aortic compared to cava vein ECs shear stress-exposed cultured express increased levels stabilize stress...
CD99-like 2 (CD99L2) is a membrane protein with moderate sequence homology to CD99, which initiates cell aggregation of transfected cells and that strongly expressed on endothelial cells, neutrophils, lymphocytes. We showed recently Abs against CD99L2 inhibit neutrophil, but not T lymphocyte, recruitment into inflamed tissues. In this study, we have generated conditional gene-deficient mice for show by analyzing them in various inflammation models several results. First, gene ablation...
Recently, a new marker protein for microglial cells in the brain was postulated, transmembrane 119 (TMEM119), raising hope opportunity to reliably and unambiguously detect histologic sections. It of interest whether TMEM119 also reliable retina.Anti-TMEM119 antibodies two providers were used label microglia murine retina, labeling properties compared those against Iba1 CD11b. As an example pathologic situation, performed eyes treated by argon laser as experimental model choroidal...
Actin-binding proteins are essential for linear and branched actin filament dynamics that control shape change, cell migration junction remodeling in vascular endothelium (ECs). The epithelial protein lost neoplasm (EPLIN) is an actin-binding protein, expressed as EPLIN-α EPLIN-β by alternative promoters, however, the isoform-specific functions not yet understood. Aortic compared to cava vein ECs shear stress-exposed cultured EC express increased levels stabilizes stress fibers. In contrast,...
Deutschlandweit herrscht in Kliniken Fachkräftemangel, vor allem der Pflege. Das spürt auch das Universitätsklinikum Gießen und Marburg. Doch was hat, neben Pandemie, die Privatisierung 15 Jahren damit zu tun?
Trans-Endothelial-Migration (TEM) of leukocytes through activated endothelium is based on modulation actin dynamics, which facilitates docking, the formation diapedesis pore and resealing this pore. Here we show that two actin-binding isoforms Epithelial-Protein-Lost-In-Neoplasm (EPLIN) differentially control endothelial dynamics during leukocyte diapedesis. Gene silencing by different methods, re-expression studies functional assays demonstrate EPLIN-α modulates branched to form docking...
Mit dem Krankenhauszukunftsfonds schafft die Bundesregierung ein finanzielles Förderinstrument, um Digitalisierung der Krankenhäuser – und so auch Notaufnahmen voranzutreiben. Verantwortliche in Kliniken Fachverbänden sehen jedoch noch Optimierungsbedarf.
Ein MRT-taugliches Ultraschallgerät erleichtert die frühe Diagnose angeborener Herzfehler bereits beim Kind im Mutterleib. Es synchronisiert fötalen Herzschlag und MRT-Aufnahmerate, sodass Bilder des kleinen Herzens nicht verwackelt, sondern scharf sind. Das soll den jungen Patientinnen Patienten eine optimale Therapie ermöglichen.