A5016139132- Nicotinic Acetylcholine Receptors Study
- Neurological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Vagus Nerve Stimulation Research
- Biochemical effects in animals
- Cancer, Stress, Anesthesia, and Immune Response
- Heart Rate Variability and Autonomic Control
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Pharmacovigilance and Adverse Drug Reactions
- Sulfur Compounds in Biology
- Silymarin and Mushroom Poisoning
- Neurological Disease Mechanisms and Treatments
- RNA and protein synthesis mechanisms
- Natural Compound Pharmacology Studies
- Endoplasmic Reticulum Stress and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinoids in leukemia and cellular processes
- Stress Responses and Cortisol
- Vitamin K Research Studies
- Plant Toxicity and Pharmacological Properties
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- S100 Proteins and Annexins
- Drug-Induced Hepatotoxicity and Protection
İzmir University of Economics
2021-2025
Dokuz Eylül University
2019-2025
Abstract Objectives This study aimed to compare blood choline levels and its correlations with bone mineral density (BMD) calcium, vitamin D, parathyroid hormone (PTH) in patients osteoporosis healthy controls. Background Osteoporosis is a condition marked by reduced higher risk of fractures, posing major health concern. Cholinergic activity promotes formation, while inhibition may contribute loss. Methods Blood 64 female participants, 38 26 were measured using ELISA, BMD was assessed via...
Sciatic nerve injury (SNI) is a common model for studying peripheral damage and regeneration. This study investigates the complications associated with acute (ANI) by laceration of sciatic in rats including infection, edema, cannibalism, evaluates effectiveness therapeutic interventions to modulate observed complications. For this purpose eighteen female wistar albino were divided into three groups: control, sham-operated, ANI. The ANI induced dissection repair right nerve. Post-surgical...
Abstract Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is well-established for its metabolic benefits, including glycemic control and weight loss. Beyond these roles, it exhibits significant anti-inflammatory properties, though the mechanisms remain underexplored. This study investigates effects of liraglutide in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Results demonstrate that increasing concentrations suppresses LPS-elevated prostaglandin E2...
Introduction: The purpose of this study is to delineate anti-inflammatory and antioxidant potential varenicline, a cigarette smoking cessation aid, on decreasing lipopolysaccharide (LPS)-elevated proinflammatory cytokines in RAW 264.7 murine macrophage cultures which we showed earlier occur via cholinergic pathway (CAP) activation. To end, investigated the possible suppressive capacity varenicline LPS-regulated cyclooxygenase (COX-1 COX-2) α7 nicotinic acetylcholine receptor (α7nAChR)...
Abstract Objectives The variability in the time intervals between heartbeats, known as heart rate (HRV), serves a reflection of intricate interplay sympathetic and parasympathetic neural systems. While potential asymmetric effects left right branches vagus nerve remain uncertain, this study aims to investigate impact unilateral, bilateral, atropine interventions on HRV parameters choline levels within cardiac tissue. Methods 40 male adult Wistar albino rats were randomly assigned five groups...
The cholinergic anti-inflammatory pathway plays an important role in controlling inflammation. This study investigated the effects of varenicline, α7 nicotinic acetylcholine receptor (α7nAChR) agonist, on inflammatory cytokine levels, cell proliferation, and migration rates a lipopolysaccharide (LPS)-induced inflammation model RAW 264.7 murine macrophage lines. cells were treated with increasing concentrations followed by LPS incubation for 24 h. Prior to receptor-mediated events,...
The purpose of this study is to investigate the effects cholinergic anti-inflammatory pathway (CAP)-activating drugs, choline and citicoline (Cytidinediphosphate-choline, CDP-choline), on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) parameters contribution NADPH Oxidase4 (NOX4) p22phox.Endotoxemia induces a systemic inflammatory response characterized by production pro-inflammatory mediators reactive oxygen species (ROS), which eventually develops (AKI). p22phox contributes...
Abstract Objectives Inflammation can be endogenously modulated by the cholinergic anti-inflammatory pathway via calcium (Ca 2+ )-permeable alpha-7 nicotinic acetylcholine receptor (α7nAChR) ion channel expressed in immune cells. α7nAChR agonist choline and tryptophan metabolite kynurenic acid (KYNA) produces immunomodulatory effects. This study aimed to determine effects of KYNA on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)-2 pathway. Methods In vitro inflammation model was...
Background: Cholinergic anti-inflammatory pathway endogenously controls inflammatory processes through activation of the α7-nicotinic acetylcholine receptor (α7nAChR). Varenicline, used in smoking cessation therapy, is a full α7nAChR agonist with effects. In this study, frequency coronavirus disease (COVID-19) was evaluated patients using varenicline as treatment. Methods: retrospective cross-sectional records 111 admitted to Smoking Cessation Outpatient Clinic Dokuz Eylul University Faculty...
Abstract Objectives Toll-like receptor (TLR) mediated inflammatory status plays an important role in development and progression of hepatocellular carcinoma (HCC). Toll-interacting protein (TOLLIP) has inhibitory effect on TLR-mediated signalling expression profile TOLLIP varies between malignancies including HCC. Cholinergic anti-inflammatory pathway (CAP) is endogenous mechanism that controls via α7nicotinic acetylcholine receptors (α7nAChR). This study aims to investigate the CAP-acting...
<title>Abstract</title> The cholinergic system, traditionally associated with neurotransmission, has been recognized for its involvement in bone physiology and osteogenesis. This study investigates the effects of CDP-choline, a compound known neuroprotective properties, on osteogenic differentiation pre-osteoblastic MC3T3-E1 cells. objective was to determine if CDP-choline could enhance key markers osteogenesis, such as alkaline phosphatase (ALP) activity, hydroxyproline (HYP) content,...
Severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) or coronavirus infectious disease (COVID-19) outbreak is continued to spread all over the world recently with high mortality and morbidity rates. It also known well leading causes of lung injury distress syndrome (ARDS), septic shock multi organ failure. Current treatment COVID-19 includes different strategies targeting preventing viral replication treating secondary infections decreasing exaggerated immune response. Although...
Objective: Heart rate variability (HRV) is used to evaluate the autonomic activity of heartbeat. This study aimed investigate effects cholinomimetic drugs cytidine diphosphate-choline (CDP-choline) and choline, on short-term HRV parameters. Materials Methods: Animals were randomized into three groups; control (0.9% NaCl), choline (100 mg/kg), CDP-choline (400 mg/kg). Electrocardiography recordings obtained for 45-minutes after treatments with 15-minutes intervals. analyses total level...
Background and Objective: Hypericum perforatum L. (HP) is a popular herbal medicine with different pharmacological effects.This study investigated the possible cholinergic receptor affinities of HP extract its three active constituents: hyperforin, hypericin pseudohypericin.Materials Methods: Radioactive compounds [3H]-N-methyl scopolamine used for muscarinic binding studies in Chinese hamster ovary cells expressing human subtypes [3H]-cytisine nicotinic tests performed mouse brains without...