A5084563692- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Chemical Synthesis and Analysis
- Research on Leishmaniasis Studies
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- X-ray Diffraction in Crystallography
- Trypanosoma species research and implications
- Enzyme Production and Characterization
- Crystallization and Solubility Studies
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Marine Sponges and Natural Products
- Toxin Mechanisms and Immunotoxins
- Malaria Research and Control
- Biochemical and Molecular Research
- Computational Drug Discovery Methods
- Catalytic Alkyne Reactions
- Synthesis and Catalytic Reactions
- Natural product bioactivities and synthesis
University of Lucknow
2014-2025
Spectrum Research (United States)
2023-2024
Munger University
2020-2024
Institute of Electrical and Electronics Engineers
2023
Canadian Standards Association
2023
Banaras Hindu University
2021
Central Drug Research Institute
2008-2020
Balaji Utthan Sansthan
2017
Academy of Scientific and Innovative Research
2016
We have developed an efficient cyanuric chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a–3x), 2-spiroquinazolinone (5, 7), and glycoconjugates (10a, 10b) derivatives. The reaction allows rapid cyclization (8–20 min) with 10 mol % to give skeletal complexity in good excellent yield. believe that this novel procedure may open door easy generation new bioactive quinazolinones.
Novel β-carboline–quinazolinone hybrids are able to inhibit <italic>Leishmania donovani</italic> TR (LdTR). Molecular docking studies investigate possible binding sites were performed.
An efficient approach for the synthesis of indole- and pyrrole-fused diketopiperazines has been developed. This protocol involves Ugi four-component reaction (U-4CR) followed by an intramolecular cyclization products at room temperature to afford desired in good excellent yields. In addition, it is interesting report subsequent regioselective ring-opening diketopiperazine unit occurring via intermolecular transamidation under mild condition, resulting formation highly functionalized...
A metal-free facile and efficient two-step synthetic protocol for the preparation of 1,4-benzoxazepine-5(2<italic>H</italic>)-one derivatives has been developed.
New chloroquinolinyl arylsulfonamides with potential antimalarial activity inhibited hemozoin formation exceedingly well.
A trisaccharide containing a d-mannosamine moiety and tetrasaccharide an l-rhamnan chain that are found in the cell walls of Azospirillum brasilense S17 were synthesized concisely excellent yields. The key features synthetic strategy stereoselective glycosylations minimum number protecting-group manipulations.
The existing antileishmanial drugs for complete cure of visceral leishmaniasis (kala-azar) are limited. available either toxic or less effective leading to disease relapse conversion post-kala-azar dermal leishmaniasis. Several herbal extracts have been shown activity, but a drug may not always be safe. In the present study, extract Cedrus deodara leaves has standardized and tested immunomodulatory activities.The C. with different solvents such as benzene, chloroform, ethyl acetate methanol...
Abstract: The thiazole ring is a unique heterocyclic motif among compounds. This five-member with one nitrogen and sulphur atom displays wide array of pharmacological activities, including anti-inflammatory, antimicrobial, anticancer, antidiabetic, antiviral, etc., by acting on several targets. Its broad range medical applications has inspired us to study this opulent molecule. current review summarizes synthetic approaches for the preparation derivatives in brief discusses promising...
Abstract A new and efficient protocol is presented for selective direct oxidative conversion of phenylmethylene-2-thiohydantoins to corresponding hydantoins. It involves the use SnCl2.2H2O, which oxidatively desulfurizes their hydantoin analogues in good excellent yields while all other 2-thiohydantoins remain unaffected. Supplemental materials are available this article. Go publisher's online edition Phosphorus, Sulfur, Silicon Related Elements view free supplemental file. GRAPHICAL ABSTRACT
The Biginelli product dihydropyrimidinones (DHPMs) and its derivatives have enormous biological significance. This article described the exploration of 2-chloro-1-methylpyridinium iodide (CMPI) reagent for development an environmentally safe, solvent-free protocol to construct functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones. involves three-component condensation reaction β-keto ester, aldehyde, urea or thiourea at elevated temperature. key advantages are capacity provide both...
Abstract A novel and efficient procedure for the synthesis of highly substituted 2H‐benzo[e][1,3]oxazin‐4(3H)‐one is reported. The strategy utilizes Ugi four‐component reaction (Ugi‐4CR) methodology to afford adduct having free hydroxyl (‐OH) functional group followed by Cu/base mediated regioselective intramolecular dehydrogenative (sp 3 ) C−O bond coupling. prepared scaffolds are found in a number pharmaceutically relevant such as DRF‐2519 CX‐614 which potential discovery treatment...