A5082601257- Computational Drug Discovery Methods
- Body Composition Measurement Techniques
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Synthesis and biological activity
- HIV Research and Treatment
- High Altitude and Hypoxia
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular and Diving-Related Complications
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Nutrition and Health in Aging
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Chemical Synthesis and Analysis
- Ethnobotanical and Medicinal Plants Studies
- Lung Cancer Treatments and Mutations
- Magnesium in Health and Disease
- Lung Cancer Research Studies
- Synthesis and Catalytic Reactions
- Trace Elements in Health
- Multicomponent Synthesis of Heterocycles
KR Mangalam University
2022-2024
Defence Institute of Physiology and Allied Sciences
2011-2023
Shree Guru Gobind Singh Tricentenary University
2021-2022
Central Drug Research Institute
2012-2021
Delhi Pharmaceutical Science and Research University
2020
Swami Rama Himalayan University
2019
Institute of Medical Sciences
2019
Jawaharlal Nehru University
2017
Regional Cancer Center
2017
University of Lucknow
2016
In India, despite several effective interventions being implemented, pneumonia persists as a major cause of under-five mortality. We explore barriers and facilitators to implementing childhood management program in North Indian district. The study aims inform the development implementation strategies for resource-constrained settings. This mixed-method was conducted during formative phase an ongoing pre-post quasi-experimental study. Data collection followed Consolidated Framework...
Basu, Minakshi, Anand Swarup Malhotra, Karan Pal, Tirthankar Chatterjee, Dishari Ghosh, Kaushik Haldar, Saroj Kumar Verma, Sanjeev Kumar, Yogendra Sharma, and Ramesh Chand Sawhney. Determination of bone mass using multisite quantitative ultrasound biochemical markers turnover during residency at extreme altitude: A longitudinal study. High Alt Med Biol 14:150–154, 2013.—A group 221 male healthy volunteers Indian Army were the subjects The baseline parameters skeletal health measured their an...
Basu, Minakshi, Anand Swarup Malhotra, Karan Pal, Rajesh Kumar, Rajeev Bajaj, Saroj Kumar Verma, Dishari Ghosh, Yogendra Sharma, and Ramesh Chand Sawhney. Alterations in different indices of skeletal health after prolonged residency at high altitude man. High Alt Med Biol. 15:170–175, 2014.—Aims: The aim this study was to evaluate the effect (HA) on bone sea level (SL) residents staying an 3450 m for 4 months 1 year. assessment parameters included multisite quantitative speed sound (SOS),...
The prevalence of contact allergy to sodium metabisulfite (SMB) has increased from the range 1.4% 1.7% 3.4% 6.8% in published series over past 20 years.The aims this study were review SMB our cohort and investigate different concentrations define most appropriate concentration for patch testing.Patient records reviewed between February 2009 December 2011 obtain information on patient demographics, clinical presentation, SMB. Patients attending testing, January 2012 June 2013, tested with 3...
Abstract High altitude pulmonary edema (HAPE) susceptibility is associated with EGLN1 polymorphisms, we hypothesized that HAPE-susceptible (HAPE-S, had HAPE episode in past) subjects may exhibit abnormal HIF1α levels normoxic conditions. We measured HAPE-S and resistant (HAPE-R, no episode) individuals similar functions. Hemodynamic responses were also before after normobaric hypoxia (Fi02 = 0.12 for 30 min duration at sea level) both groups. . was higher (320.3 ± 267.5 vs 58.75 33.88 pg/ml,...
Beetroot juice contains a high level of biologically accessible antioxidants, beneficial phytochemicals and dietary nitrate, which seem to exert effects in human health. Dietary from beetroot has been reported lower blood pressure. However the impact on lipid profile oxidative stress is unknown. In present study, effect supplementation with for 15 days was investigated. Plasma profile, antioxidant status, body composition changes were evaluated at baseline after supplementation. beneficially...
Hematuria and eosinophilia developed in two patients being treated for bacterial endocarditis with 20 or 24 gm/day of cephalexin given orally together probenecid (Benemid). One patient had a concurrent transient increase serum creatinine; both history penicillin allergy previously received intravenously. All abnormalities promptly remitted following discontinuation therapy.
New chloroquinolinyl arylsulfonamides with potential antimalarial activity inhibited hemozoin formation exceedingly well.
The X-ray crystal structures of HDAC8 complexed with largazole thiol (LAR, PubChem CID: 56663191) and its synthetic variants (Ligand ID in PDB, L6G, 91667418; L7G, 91667421; L8G, 91667420) (PDB codes: 3RQD, 4RN0, 4RN2 4RN1) were analyzed using molecular dynamics simulations to comprehend protein-ligand nonbonding energies (NBEs). NBEs ligands' substructures vis-à-vis active site indicated that pyridyl fragment (F2B4) L7G amide (F2B5) LAR L6G are high energy states. Based on residues...
This study aims to redefine obesity cut-off points for body mass index (BMI) and fat (FMI) according the different age groups of physically active males. Healthy volunteers (N = 1442) aged 18–57 years (y), with a mean BMI 22.7 ± 2.8 kg/m2, FMI 4.3 1.7 kg/m2 were recruited from various fitness centers. was calculated individuals categorized Asia–Pacific criterion ≤22.9 previous WHO-guided ≤24.9 kg/m2. also participants 6.6 Redefining values carried out based on difference 10 y 5 using...
A 65-year-old woman presented with widespread necrotising cutaneous ulceration and oral involvement. Past history included rheumatoid arthritis, a left nephrectomy.Examination revealed multiple violaceous undermined ulcers. Blood investigations showed an acute inflammatory response. Skin histopathology epidermal chronic inflammation. Direct immunofluorescence was negative. diagnosis of pyoderma gangrenosum involvement made. Mycophenolate mofetil therapy resulted in complete resolution her...
This study aims to identify the clinical and genetic markers related two uncommon nutritional statuses—metabolically unhealthy normal-weight (MUNW) metabolically healthy overweight/obese (MHOW) individuals in physically active individuals. Physically male volunteers (n = 120) were recruited, plasma samples analyzed for parameters. Triglycerides, HDL-Cholesterol, LDL-cholesterol, total cholesterol, C-reactive protein, insulin resistance considered as of metabolic syndrome. The subjects...
The study reports the QSAR rationales from multilateral approaches for antimalarial activities (against W2 and TM90-C2B strains of Plasmodium falciparum) physical properties (aqueous solubility, permeability logD) 1,2,3,4-tetrahydroacridin-9(10H)-one (THA) derivatives. A modification to Free-Wilson matrix (parameter set) is introduced improve compound parameter ratio analysis carried out in study. models modified physicochemical parameters suggest that 5(th) (R1) 8(th) (R4) positions THA...