A5054028741- High Altitude and Hypoxia
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Muscle metabolism and nutrition
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dietary Effects on Health
- Spaceflight effects on biology
- Exercise and Physiological Responses
- Heart Rate Variability and Autonomic Control
- Eicosanoids and Hypertension Pharmacology
- Natural Antidiabetic Agents Studies
- Cardiovascular and exercise physiology
- Fungal Biology and Applications
- Nitric Oxide and Endothelin Effects
- Cardiovascular Disease and Adiposity
- Complementary and Alternative Medicine Studies
- Food Science and Nutritional Studies
- Health Systems, Economic Evaluations, Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Circadian rhythm and melatonin
Defence Institute of Physiology and Allied Sciences
2014-2024
Defence Research and Development Organisation
2014
The circulatory levels of two appetite regulatory hormones i.e. leptin and ghrelin were estimated in sojourners acclimatized subjects to investigate their possible role high altitude (HA) induced anorexia. A group 30 lowlanders who had never visited HA inducted a height 3600m by air after 48h they further taken an 4300m road. Blood samples collected stay at again 7 days during 0700–0730h. There was decrease energy intake (850kcal/day) sojourners, which resulted loss body weight 2.12kg HA. At...
The concept of L-carnitine (L-CAR) supplementation to improve muscular performance is based on the role L-CAR in regulating aerobic metabolism. has also been found attenuate free radical-induced oxidative stress various pathological conditions. Thus, it was hypothesized that may reduce intermittent hypoxia (IH)-induced and thereby benefit skeletal muscle performance. Thirty-six adult male Sprague-Dawley rats were divided into three groups: unexposed control; IH exposed (6 h day(-1) for 7...
Vats, Praveen, Koushik Ray, Dhurjati Majumadar, Amitabh, Duraisamy Arul Joseph, Susovon Bayen, Almaz Akunov, Akpav Sarbaev, Shashi Bala Singh. Changes in cardiovascular functions, lipid profile, and body composition at high altitude two different ethnic groups. High Alt Med Biol 14:45–52, 2013.—High (HA) presents inhospitable environmental conditions that adversely affects human physiology metabolism. physiological functions are reported during exposure, but the changes vary with physical...
Abstract High altitude pulmonary edema (HAPE) susceptibility is associated with EGLN1 polymorphisms, we hypothesized that HAPE-susceptible (HAPE-S, had HAPE episode in past) subjects may exhibit abnormal HIF1α levels normoxic conditions. We measured HAPE-S and resistant (HAPE-R, no episode) individuals similar functions. Hemodynamic responses were also before after normobaric hypoxia (Fi02 = 0.12 for 30 min duration at sea level) both groups. . was higher (320.3 ± 267.5 vs 58.75 33.88 pg/ml,...
High altitude (HA) exposure usually leads to a significant weight loss in non-acclimatized humans. Anorexia is believed be the main cause of this body loss. Appetite regulatory peptides, i.e. leptin and neuropeptide Y play key role food intake energy homeostasis. Recent studies suggests increased oxidative stress during HA exposure. In present study effect on levels NPY was evaluated along with N-acetyl cysteine (NAC) vitamin E supplementation relation changes. The conducted 30 healthy male...
Humans have a number of mechanisms for protection against reactive oxygen species, but under stressful conditions these defenses are not completely successful. Glutathione plays an important role in free radicals and species induced damages. The present study was undertaken to understand the effect high-altitude (HA) exposure on glutathione metabolism antioxidant status along with effects N-acetyl cysteine (NAC) vitamin E supplementation humans.The conducted 30 healthy male volunteers (age...
Introduction: A high-altitude environment causes appetite loss in unacclimatised humans, leading to weight reduction. Ghrelin, cholecystokinin (CCK), and glucagon like peptide-1 (GLP-1), are gut hormones involved the regulation of food intake energy metabolism. The liver is an important site metabolic regulation, together with it plays a role regulation. This study intends timedependent changes occurring plasma hormones, PPARα, PPARδ, PGC1α, stomach during hypoxia. Material methods: Male...
Introduction: Cognitive function has been compromised during high-altitude (HA) exposure due to slowing of mental processing. Materials and Methods: A total 20 Indian Kyrgyz soldiers were studied at 4111 m assess cognitive in two different ethnic groups. Paired associate learning, pattern recognition memory, spatial span (SSP), working memory (SWM), choice reaction time (CRT), simple (SRT) evaluated sea level on days 3, 7, 14, 21 HA stay day 3 deinduction. Results: All the parameters...
High altitude (HA) conditions induce several physiological and molecular changes, prevalent in individuals who are unexposed to this environment. Individuals exposed towards HA hypoxia yields orchestration maintain adequate tissue oxygen delivery supply at altitude. This study aimed understand the temporal changes of 4,111m. Physiological parameters transcriptome was conducted high day 3, 7, 14 21. We observed differentially expressed gene (DEG) time points along with altered BP, HR, SpO2,...
Gaur, Priya, Meerim Sartmyrzaeva, Abdirashit Maripov, Kubatbek Muratali Uulu, Supriya Saini, Koushik Ray, Krishna Kishore, Almaz Akunov, Akpay Sarybaev, Bhuvnesh Kumar, Shashi Bala Singh, and Praveen Vats. Cardiac acclimatization at high altitude in two different ethnicity groups. High Alt Med Biol. 22:58–69, 2021. Introduction: (HA) exposure causes substantial increase pulmonary artery pressure (PAP) resistance. However, the effects of HA hypoxia on cardiac function remain incompletely...
Nutritional requirements of sailors and submariners are different from those ground forces as they work under confined environment well due to logistic constraints cooking storage food. Study was conducted for a period three months at Eastern Naval Command evaluate nutrient requirements, nutritional status Indian Navy personnel adequacy the existing ration scales. The study volunteers were crew two warships (n = 35) 20) who attached their mother ships during time data collection offshore...