A5087565347- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemostasis and retained surgical items
- Blood transfusion and management
- Periodontal Regeneration and Treatments
- Blood properties and coagulation
- Platelet Disorders and Treatments
- Biosimilars and Bioanalytical Methods
- Wound Healing and Treatments
- Surgical Sutures and Adhesives
- Trauma and Emergency Care Studies
Adlyfe (United States)
2007
Brigham and Women's Hospital
2007
Harvard University
2007
University of Padua
2007
Background Uncontrolled hemorrhage is responsible for ∼80% of the potentially survivable deaths in combat and over 40% early mortality under 65 age group United States. Providing an easily used infusible hemostatic agent to first responders could significantly reduce these fatalities. We report on lyophilized platelet‐derived stabilized with trehalose polysucrose prior during lyophilization. Study Design Methods Characterization included determining particle population size range, surface...
BACKGROUND: The wound‐healing applications of platelet (PLT)‐derived cytokines, proteins, and membranes is accepted but continues to be investigated. In this study, it demonstrated that stabilized freeze‐dried PLTs prepared from outdated (FDPOs) accelerate wound healing form tube structures as well indated (FDPIs) room‐temperature fresh (RT‐PLTs). STUDY DESIGN AND METHODS: Experiments were designed compare in vitro vivo properties FDPI, FDPO, RT‐PLT preparations. concentration PLT‐derived...
Hemorrhagic shock (HS) and trauma induce endothelial barrier compromise, inflammation, aberrant clotting. We have shown that fresh human platelets (Plts) Plt extracellular vesicles mitigate vascular leak in murine models of injury. Here, we investigate the potential freeze-dried (FDPlts) to attenuate pulmonary permeability, decrease promote clotting a model HS.Human FDPlts were characterized using vitro assays marker expression, aggregation, coagulation, cell permeability. An intravital...
Abstract Thrombosomes are trehalose‐stabilized, freeze‐dried group O platelets with a 3‐year shelf life. They can be stockpiled, rapidly reconstituted, and infused regardless of the recipient's blood type. thus represent potential alternative platelet transfusion strategy. The present study assessed safety early signals efficacy in bleeding thrombocytopenic patients. We performed an open‐label, phase 1 single doses allogeneic at three dose levels cohorts, each consisting eight patients who...
A safe and efficacious hemostatic product with a long shelf-life is needed to reduce mortality from hemorrhage due trauma improve surgical outcomes for persons platelet deficiency or dysfunction. Thrombosomes, trehalose-stabilized, leukoreduced, pooled blood group-O freeze-dried platelet-derived (FPH) 3-year shelf-life, may satisfy this need.
Dimethylsulfoxide-cryopreserved platelets are being evaluated for treatment of acute hemorrhage in patients with thrombocytopenia or platelet dysfunction when liquid stored unavailable. Patients undergoing cardiac surgery cardiopulmonary bypass risk factors significant bleeding represent a population which determining efficacy and safety cryopreserved is ideal the clinical trial setting. The primary objective to compare blood loss receiving platelets.
A freeze-dried, platelet-derived hemostatic agent (FPH) was developed for acute hemorrhage. The canine product (cFPH) use in preclinical models supporting human (hFPH) investigations.