A5066314245- Polish Historical and Cultural Studies
- Intellectual Property Rights and Media
- Language and Culture
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Polish-Jewish Holocaust Memory Studies
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Social Issues in Poland
- Immune cells in cancer
- Polish socio-economic development
- HER2/EGFR in Cancer Research
- Carbohydrate Chemistry and Synthesis
- Chemokine receptors and signaling
- Alkaline Phosphatase Research Studies
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Breast Cancer Treatment Studies
- Polish Law and Legal System
- Lung Cancer Research Studies
University of Łódź
2012-2024
Analiza (United States)
2024
Orange (Poland)
2024
Novartis (United States)
2015-2020
Hanover College
2016
Human Genome Sciences (United States)
2000-2004
Cleveland Clinic
2004
Indiana University – Purdue University Indianapolis
2004
The University of Texas Health Science Center at Houston
2004
The University of Texas Health Science Center at San Antonio
2004
As part of a large scale effort to discover novel secreted proteins, cDNA encoding cytokine was identified. Alignments the sequence new protein, designated IL-17B, suggest it be homolog recently described T cell-derived cytokine, IL-17. By Northern analysis, EST distribution and real-time quantitative polymerase chain reaction mRNA detected in many cell types. A type I transmembrane identified an data base by homology IL-17R, found bind specifically as determined surface plasmon resonance...
Abstract Background: In patients (pts) with ER+/HER2− metastatic breast cancer (MBC) following progression on prior endocrine and CDK4/6i therapy, the EMERALD trial demonstrated significantly prolonged progression-free survival (PFS) a manageable safety profile for elacestrant versus standard of care therapy (SoC). Benefit was observed in all pts ESR1 mutant MBC (ESR1-mut). is only oral SERD monotherapy pivotal where were pretreated CDK4/6 inhibitor (CDK 4/6i). Here, we examine impact...
Transforming growth factor beta 1 (TGF-beta 1) and TGF-beta 2 can reversibly inhibit the proliferation of hematopoietic progenitor cells in vivo, leading us to hypothesize that such quiescent progenitors might be more resistant high doses cell cycle active chemotherapeutic drugs, thereby allowing dose intensification agents. Initial studies showed whereas administration or did not prevent death normal mice treated with 5-fluorouracil (5-FU), those received exhibit beginning a hematologic...
Abstract Background: Elacestrant demonstrated significantly prolonged progression-free survival (PFS) and a manageable safety profile compared with standard of care endocrine therapy in the phase 3 EMERALD trial that enrolled patients estrogen-receptor positive (ER+)/HER2− mBC following disease progression on prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) therapy. Benefit was observed overall population ESR1 mutations. Combining elacestrant targeted agents utilized combination is...
Administration of recombinant human interleukin 7 (rh)IL-7 to mice has been reported by our group increase the exportation myeloid progenitors (colony-forming unit [CFU]-c and CFU-granulocyte erythroid megakarocyte macrophage) from bone marrow peripheral organs (blood, spleen[s], liver). We now report that IL-7 also stimulates a sixfold in number more primitive CFU-S day 8 (CFU-S8) 12 (CFU-S12) blood leukocytes (PBL) treated with rhIL-7 for d. Moreover, > 90% lethally irradiated recipient...
Swainsonine, an indolizidine alkaloid, was recently reported to exhibit both antineoplastic and immunomodulatory activities (Humphries, M.J.; Olden, K. Asparagine-linked oligosaccharides tumor metastasis. Pharmacol. Ther. 44:85-105; 1989). In this study, we show that systemically administered swainsonine promoted the proliferation of murine bone marrow (BM) cells. Animals received intravenously exhibited a significant increase (approximately 5-10 fold) in BM cellularity, engraftment...
Journal Article Protective Effects of Swainsonine on Murine Survival and Bone Marrow Proliferation During Cytotoxic Chemotherapy Get access Oladipo A. Oredipe, Oredipe Howard University Cancer Center, College MedicineWashington, D.C. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sandra L. White, White Krzysztof Grzegorzewski, Grzegorzewski Barry Gause, Gause Jin K. Cha, Cha Center Department Microbiology, Vitilla Miles, Miles Internal Medicine, Kenneth Olden...
Previous studies in our laboratory have shown that the reported antitumor activity of systemically administered swainsonine, an indolizidine alkaloid, is due at least part to immune modulation involving effector cells (Humphries, M.J.; Matsumoto, K; White, S.L.; Olden, K. Cancer Res. 48:1410-1415; 1988 and S. L.; Schweitzer, K.; Humphries, Biochem. Biophys. Commun. 150:615-625; 1988). In this report, are presented show swainsonine was effective activating peritoneal macrophages cytotoxicity...
Abstract Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors bone marrow engraftment. Reconstitution with from rhIL-7-treated mice results in a 3.4-fold decrease total colony-forming unit-spleen (CFU-S) activity (day 9) an 18.1- 11.9-fold its ability generate thymocytes splenic B lineage cells, respectively. In contrast, after splenocytes mice, CFU-S increased 23.6-fold thymocyte cell regenerative...
Abstract Objectives: The addition of a CDK 4/6 inhibitors to endocrine therapy, in the first or second line setting, provides significant improvement progression free survival (PFS), and some cases overall (OS), with tolerable toxicity profile. Regardless, most patients experience disease on these agents ultimately develop resistance, thus, emphasizing critical need for novel treatments. Elacestrant showed statistically PFS when compared standard care therapy after CDK4/6 combination (Bidard...
Abstract Background: MEN1611 (MEN) is an oral PI3K inhibitor active on the p110α mutant and wild type, β γ isoforms, while sparing δ. B-PRECISE-01 open-label, 2-arm, phase 1b study investigating in combination with trastuzumab ± fulvestrant patients HER2 positive/PIK3CA mutated metastatic breast cancer (MBC). No dose-limiting toxicities were observed during dose-escalation step 48 mg BID was selected as recommended 2 dose (RP2D) for cohort expansion (CE). Methods: Eligible had...
The level of Ca2+, phospholipid-dependent, protein kinase C (PKC) activity in murine peritoneal macrophages treated with swainsonine, an indolizidine alkaloid, has been investigated. present studies are based on our recent report that activated by swainsonine (Grzegorzewski, K.; Newton, S.A.; Akiyama, S.K.; Sharrow, S.; Olden, White, S.L., Cancer Commun. 1:373-379, 1989). Presently, we have demonstrated exhibited a substantial increase PKC activity. was enhanced as much 4- to 5-fold over...
Abstract Background:While TNBC patients with pathologic complete response (pCR) or residual cancer burden (RCB-I) have good survival rates, those extensive disease (RCB-II RCB-III) after neoadjuvant chemotherapy (NACT) poor prognosis. Patients without to their first chemotherapeutic regimen very low chance (5%) of achieving pCR. We created a biomarker-driven drug development strategy, ARTEMIS (A Randomized, Enrolling trial confirm Molecular profiling Improves Survival) identify novel...
Tekst jest poświęcony charakterystyce newsów we współczesnych programach telewizyjnych, takich jak wiadomości i programy w całodobowych stacjach informacyjnych (np. TVN24). Autor proponuje definicję newsa oraz podejmuje próbę scharakteryzowania sposobu jego funkcjonowania polskich warunkach, ilustrując tezy przykładami. Możliwie pełna charakterystyka (uwzględniając takie problemy, treść czy najważniejsze cechy charakterystyczne) umożliwia pozycjonowanie klasyfikowanie wydarzeń analizę mediach.