A5111282878- Systemic Lupus Erythematosus Research
- Cardiac, Anesthesia and Surgical Outcomes
- Vasculitis and related conditions
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Surgical site infection prevention
- Lymphoma Diagnosis and Treatment
- Maternal and Perinatal Health Interventions
- Food composition and properties
- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Autoimmune Bullous Skin Diseases
- Otitis Media and Relapsing Polychondritis
- Cutaneous lymphoproliferative disorders research
- Ultrasound in Clinical Applications
- Musculoskeletal synovial abnormalities and treatments
- Pickering emulsions and particle stabilization
- COVID-19 and healthcare impacts
- Microbial Metabolites in Food Biotechnology
- Dendrimers and Hyperbranched Polymers
- Genetic Associations and Epidemiology
- T-cell and B-cell Immunology
- Global Health and Surgery
Instituto de Ciencia y Tecnología de Alimentos y Nutrición
2021-2025
Universidad Complutense de Madrid
2025
Hospital de Mataró
2025
Maresme Health Consortium
2025
Consejo Superior de Investigaciones Científicas
2022-2024
Institut de Virologie
2021
Complejo Asistencial Universitario de Palencia
2017-2020
Hospital de León
2018
FC Barcelona
2018
Complexo Hospitalario Universitario A Coruña
2016
A masking/toposelective modification approach was employed to prepare a new organic-inorganic Janus nanomaterial by attaching ethylenediamine core polyamidoamine G-4.5 dendrimers defined face of mesoporous silica nanoparticles. The anisotropic colloid then sequentially functionalized on the with (3-isocyanatopropyl)triethoxysilane, 1-(4-aminophenyl)-2-phenylethane-1,2-dione and β-cyclodextrin assemble novel H2O2-sensitive gating mechanism. nanomachine finally constructed immobilizing glucose...
Type 2 diabetes is associated, among other alterations, with increased metabolic disturbances during the postprandial state. Cocoa and carob have shown promising effects for its management, mostly in preclinical studies,...
Diabetic cardiomyopathy (DCM) is one of the main causes mortality among diabetic patients, with oxidative stress and inflammation major contributors to its development. Dietary flavonoids show strong antioxidant anti-inflammatory activities, although their potential additive outcomes in combination antidiabetic drugs have been scarcely explored. The present study investigates cardioprotective effects a cocoa-carob blend (CCB) diet, rich flavonoids, alone or metformin, development DCM. Zucker...
EC and DHBA, alone or in combination with MET, alleviated glucolipotoxic-induced cardiac damage cultured cells by regulating the redox status, autophagy apoptosis.
Cumulative evidence indicates the relevance of cocoa in modulation cardiometabolic diseases. Nevertheless, pure may be rejected by many consumers due to its bitter taste. Carob (Ceratonia siliqua L.) is a Mediterranean legume with pods rich dietary fibre and polyphenols. In this study, carob flour was combined cocoa, obtain blend which subjected nutritional evaluation (proximate composition, carbohydrate fatty acid profiles, phytochemical properties, antioxidant capacity) sensory analysis,...
Abstract Background There is controversy regarding the maximum number of elements that can be included in a surgical site infection prevention bundle. In addition, it unclear whether bundle this type implemented at multicentre level. Methods A pragmatic, cohort study was designed to analyse rates elective colorectal surgery after sequential implementation two preventive protocols. Secondary outcomes were determine compliance with individual measures and establish their effectiveness,...
Epicatechin (EC) and main colonic phenolic acids derived from flavonoid intake have been suggested to exert healthful effects, although their mechanism of action remains unknown. Heart damage is highly prevalent in metabolic diseases, the failure this organ a major cause death worldwide. In study, modulation energy metabolism insulin signalling by mentioned compounds cardiac H9c2 cells was evaluated. Incubation with EC (1-20 μM) 2,3-dihydroxybenzoic acid (DHBA, 10 reduced glucose uptake,...
We have recently developed a cocoa–carob blend (CCB) rich in polyphenols with antidiabetic properties. In this study, we investigated whether its benefits could be related to gut health and microbiota (GM) composition the likely phenolic metabolites involved. Zucker diabetic fatty rats were fed on standard or CCB-rich diet for 12 weeks. Intestinal barrier structure oxidative inflammatory biomarkers analyzed colonic samples. GM evaluated from feces. The results show that CCB improved mucin...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with wide range of clinical manifestations. The persistence activity the and prolonged use corticosteroids are amongst main predictors accumulated organ damage in patients SLE. Therefore, we need new strategies to induce long-lasting remission minimise adverse effects standard medications. <h3>Objectives</h3> assess effectiveness safety Belimumab actual practice during first year treatment...
The liver and kidneys are crucial for glucose homeostasis seriously damaged in diabetes. Cocoa carob possess antidiabetic activity, but their hepatorenal protective effects, especially when combined with drugs, unknown. aim of this study is to investigate the effects a cocoa-carob-supplemented diet (CC), either alone or combination metformin, on kidney damage Zucker diabetic fatty (ZDF) rats, type 2 diabetes model. Male ZDF animals received control CC-supplemented diet, without lean rats...
There is no agreement as to the frequency and characteristics of epileptic seizures (ES) associated with cerebrovascular disease (CVD).To analyze presence early (Se) late (SI) ES, factors related these, prognosis conversion epilepsy.We made a retrospective study 386 patients cerebral hemisphere ischemia (100 TIA 286 infarcts). Follow-up was 29.69 +/- 13.92 months. Two groups were defined: a) Patients without b) ES. Those occurring within 15 days episode considered be Se others Sl. We studied...
<h3>Background</h3> The indication or use of zoledronic acid on the Paget9s disease bone was approved in 2005. Recent studies point out administration a single intravenous dose this medicine as first therapeutic option. <h3>Objectives</h3> aim study is to determine whether there improvement ALP values among patients with after and analyze greater group previously treated oral bisphosphonates who have not received prior treatment. <h3>Methods</h3> This retrospective which included 49 that...
<h3>Background</h3> Recent genome-wide association studies (GWAS) have identified more than 50 loci associated with systemic lupus erythematosus but they explain less 30% of the heritability disease. Meta-analysis including new populations can contribute to identify additional genetic risk factors. <h3>Objectives</h3> The aim presents study was for SLE. <h3>Methods</h3> We performed a meta-analysis using data from recent large scale GWAS 4,036 cases and 6,959 controls Caucasian European...
<h3>Background</h3> Different frequency of clinical and serological manifestations has been detected according to the age onset patients with Systemic lupus erythematosus (SLE). According literature, senile SLE manifests between 6% 18% lupus. <h3>Objectives</h3> To identify analyse clinical-serological epidemiological features in our environment. determine average survival time mortality these patients, identifying its main cause. <h3>Methods</h3> Observational retrospective study 319...
<h3>Background</h3> Damage in SLE is associated with mortality. Not every damage manifestation the same way. Some studies were made assessing this relation but small and heterogeneous samples making difficult to obtain meaningful conclusions. <h3>Objectives</h3> To evaluate patterns of accrual mortality a large sample patients. <h3>Methods</h3> patients from RELESSER studied. After K-means cluster analysis, different clusters similar characteristics terms identified. Kaplan-Meier log-rank...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease with heterogeneous clinical manifestations. Recent studies have suggested the existence of genetic basis for diverse SLE phenotypes. Also, there increasing evidence indicating that substantial part variation associated diseases explained by small-effect genes from common pathways. <h3>Objectives</h3> The objective present study was to identify new phenotypes using genome-wide association at...
<h3>Background</h3> Mortality in SLE has improved over the last decades. Outcome measures as damage become more important. <h3>Objectives</h3> To study manifestations and timing of their appearance. <h3>Methods</h3> In 1st transverse phase RELESSER, accumulated information on 400 variables per patient at time evaluation was collected. We evaluated each system temporal relationship appearance with diagnosis. Cumulative incidence function for estimated.The impact mortality studied controlling...
<h3>Background</h3> Giant cell arteritis (GCA) is often a disease refractory to corticosteroids and, besides, the efficacy of immunosuppressive agents not well established. In recent years, several case reports and small series have shown with use tocilizumab (TCZ). <h3>Objectives</h3> Our aim was assess in clinical practise setting short long-term TCZ GCA patients and/or unacceptable side effects due corticosteroids. <h3>Methods</h3> Retrospective multicenter open-label study on 31 treated...
<h3>Background</h3> The drugs called Anti-TNF inhibitors are capable of inducing an immune response (immunogenicity) Its effectiveness may be affected by the development Anti-Drug Antibodies (Ab) <h3>Objectives</h3> To assess frequency appearance Antibodies: Infliximab (IFX), Adalimumab (ADA), etanercept (ETN) classify failures analyse relationship between anti-TNFα antibodies and concomitant treatment with DMARDs observe whether there is a link risk factors drug levels <h3>Methods</h3> This...
The aim of this work is to study the prevalence mycobacterial infection (M.I.), associated factors and their clinical significance in patients included a large SLE cohort. <h3>Methods</h3> Retrospective descriptive RELESSER with history M.I. analysis aetiology. <h3>Results</h3> In 3,658 were included. 90% women, mean age 32.9 years. 93% Caucasians. follow-up time (±S.D.) was 120.2 (±87.6) months. 705 (19.3%) had at least serious infection, 1227 infections occurred. diagnosed 42 (1.2% all...