Lei Shi

ORCID: 0000-0001-6877-4377
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About
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Research Areas
  • Multiple Myeloma Research and Treatments
  • Cancer Treatment and Pharmacology
  • Chemokine receptors and signaling
  • Cancer-related molecular mechanisms research
  • Chronic Lymphocytic Leukemia Research
  • Chronic Myeloid Leukemia Treatments
  • Hematopoietic Stem Cell Transplantation
  • Blood Coagulation and Thrombosis Mechanisms
  • Testicular diseases and treatments
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Monoclonal and Polyclonal Antibodies Research
  • Glycosylation and Glycoproteins Research
  • Lymphoma Diagnosis and Treatment
  • Venous Thromboembolism Diagnosis and Management
  • Quinazolinone synthesis and applications
  • Ferroptosis and cancer prognosis
  • Extracellular vesicles in disease
  • CAR-T cell therapy research

First Affiliated Hospital of Xi'an Jiaotong University
2024

Beijing Jishuitan Hospital
2020-2024

Peking University
2020-2024

Capital Medical University
2023-2024

Liver hepatocellular carcinoma (LIHC) is the third largest cause of cancer mortality. Exosomes are vital regulators in development cancer. However, mechanisms regarding association exosome-related long non-coding RNAs (lncRNAs) LIHC not clear.

10.1016/j.heliyon.2024.e24462 article EN cc-by-nc-nd Heliyon 2024-01-01

Immunoglobulin (Ig) isotype switching in multiple myeloma (MM) is a rare form of clonal evolution. The aim this study was to investigate the clinical features and prognostic significance Ig by observing transformation patients with relapse. A retrospective analysis performed on 506 newly diagnosed MM who were treated at our hospital from February 2005 2020. experienced relapse divided into following four groups according phenotype: original paraprotein, complete switching, light chain escape...

10.1016/j.cpt.2022.11.002 article EN cc-by-nc-nd Cancer Pathogenesis and Therapy 2022-11-18

Autologous hematopoietic stem cell (HSC) transplantation remains the recommended treatment for eligible patients with multiple myeloma (MM). Increasing number of transplanted CD34+ cells shorten time to reconstitution and increases overall survival patients. With harvest a sufficient being crucial, this study aimed predict factors that affect collection. We conducted retrospective 110 who were newly diagnosed MM underwent autologous HSC collection at Beijing Jishuitan Hospital between March...

10.1016/j.cpt.2022.11.004 article EN cc-by-nc-nd Cancer Pathogenesis and Therapy 2022-12-06

Abstract Introduction : Obesity has been identified as risk factor for multiple myeloma (MM). Various indexes of body fat compartment make it difficult to assess the value in predicting prognosis MM patients. Methods 36 newly diagnosed (NDMM) patients underwent abdominal CT pre-chemotherapy, and 72 matched healthy people were included. Total area (TFA), visceral (VFA) subcutaneous (SFA) measured from T12 S1 analyzed at six slices vertebral interfaces. The level adiponectin was also detected....

10.21203/rs.3.rs-31931/v1 preprint EN cc-by Research Square (Research Square) 2020-06-02
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